Voahangy Andrianaranjaka

TL;DR: It is shown that African kelch13 mutations have originated locally, and that kelCh13 shows a normal variation pattern relative to other genes in Africa, whereas in Southeast Asia there is a great excess of non-synonymous mutations, many of which cause radical amino-acid changes.

TL;DR: An individual patient data meta-analysis of the associations between parasite clearance half-life (PC1/2) and pfk13 genotype based on a large set of individual patient records from Asia and Africa demonstrates that 15 additional pfK13 alleles are associated strongly with the slow-clearing phenotype in Southeast Asia.

TL;DR: A new release of curated genome variation data on 7,000 Plasmodium falciparum samples from MalariaGEN partner studies in 28 malaria-endemic countries aims to facilitate research into the evolutionary processes affecting malaria control and to accelerate development of the surveillance toolkit required for malaria elimination.

TL;DR: The first comprehensive spatiotemporal picture of Plasmodium falciparum resistance in various geographic areas in Madagascar showed unusual profiles of chloroquine susceptibility in Madagascar, a rapid rise in the frequency of parasites with both the pfdhfr and the pFDhps mutations and the progressive loss of the most susceptible isolates to artemisinin derivatives.

TL;DR: Mitochondrial genome sequencing revealed relatively little polymorphism within the African population compared to parasites from the rest of the world, which suggests that the present day African P. vivax population in humans may have been introduced relatively recently from the Indian subcontinent.