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Sharon M. Lutz

Researcher at Harvard University

Publications -  127
Citations -  3837

Sharon M. Lutz is an academic researcher from Harvard University. The author has contributed to research in topics: COPD & Genome-wide association study. The author has an hindex of 28, co-authored 108 publications receiving 2784 citations. Previous affiliations of Sharon M. Lutz include University of Colorado Denver & University of Colorado Boulder.

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Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

James D. McKay, +146 more
- 12 Jun 2017 - 
TL;DR: 18 susceptibility loci achieving genome-wide significance are identified, including 10 new loci linked with lung cancer overall and six loci associated with lung adenocarcinoma, highlighting the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer.
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Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis

Michael H. Cho, +32 more
- 01 Mar 2014 - 
TL;DR: In this article, the authors identified risk loci for moderate to severe and severe COPD with data from several cohort studies and combined results in a joint meta-analysis (threshold for significance p −8 ).
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Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease

Alex Poole, +16 more
- 01 Mar 2014 - 
TL;DR: Nasal expression profiling can be used to identify subjects with IL13-driven asthma and a TH2-skewed systemic immune response and largely recapitulate expression profiles in the lung airways.

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

Phuwanat Sakornsakolpat, +155 more
TL;DR: Genome-wide analysis of chronic obstructive pulmonary disease identifies 82 loci, 35 of which are new, and integrates gene expression and genomic annotation data shows enrichment of signals in lung tissue, smooth muscle and several lung cell types.
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Quantitative Computed Tomography Measures of Pectoralis Muscle Area and Disease Severity in Chronic Obstructive Pulmonary Disease. A Cross-Sectional Study

Merry-Lynn McDonald, +25 more
- 27 Mar 2014 - 
TL;DR: CT-derived pectoralis muscle area provides relevant indices of COPD morbidity that may be more predictive of important COPD-related traits than BMI, however, the relationship with clinically relevant outcomes such as hospitalization and death requires additional investigation.