G
Grigori Enikolopov
Researcher at Stony Brook University
Publications - 153
Citations - 19473
Grigori Enikolopov is an academic researcher from Stony Brook University. The author has contributed to research in topics: Stem cell & Neural stem cell. The author has an hindex of 57, co-authored 148 publications receiving 17320 citations. Previous affiliations of Grigori Enikolopov include Brookhaven National Laboratory & Moscow State University.
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Journal ArticleDOI
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Simón Méndez-Ferrer,Tatyana V. Michurina,Francesca Ferraro,Amin R. Mazloom,Ben D. MacArthur,Ben D. MacArthur,Sergio A. Lira,David T. Scadden,Avi Ma'ayan,Grigori Enikolopov,Paul S. Frenette,Paul S. Frenette +11 more
TL;DR: It is demonstrated that mesenchymal stem cells (MSCs), identified using nestin expression, constitute an essential HSC niche component and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell pairs.
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Endothelial and perivascular cells maintain haematopoietic stem cells
TL;DR: HSCs reside in a perivascular niche in which multiple cell types express factors that promote HSC maintenance, and were depleted from bone marrow when Scf was deleted from endothelial cells or leptin receptor (Lepr)-expressing periv vascular stromal cells.
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Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis
Amanda Sierra,Juan M. Encinas,Juan M. Encinas,Juan J. P. Deudero,Jessica H. Chancey,Grigori Enikolopov,Linda Overstreet-Wadiche,Stella E. Tsirka,Mirjana Maletic-Savatic +8 more
TL;DR: It is shown that the majority of the newborn cells undergo death by apoptosis in the first 1 to 4 days of their life, during the transition from amplifying neuroprogenitors to neuroblasts, which suggests a new role for microglia in maintaining the homeostasis of the baseline neurogenic cascade.
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Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus
Juan M. Encinas,Tatyana V. Michurina,Natalia Peunova,June Hee Park,Julie Tordo,Daniel A. Peterson,Gordon Fishell,Alex Koulakov,Grigori Enikolopov +8 more
TL;DR: A scheme of the neurogenesis cascade in the adult hippocampus is presented that includes a proposed "disposable stem cell" model and accounts for the disappearance of hippocampal neural stem cells, the appearance of new astrocytes, and the age-related decline in the production of new neurons.
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Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis.
Jaehoon Shin,Daniel A. Berg,Yunhua Zhu,Joseph Y. Shin,Juan Song,Michael A. Bonaguidi,Grigori Enikolopov,David W. Nauen,Kimberly M. Christian,Guo Li Ming,Hongjun Song +10 more
TL;DR: The molecular continuum underlying adult neurogenesis is revealed and Waterfall, a bioinformatic pipeline, is developed to statistically quantify singe-cell gene expression along a de novo reconstructed continuous developmental trajectory.