Journal ArticleDOI
Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function
Hans-Willi Mittrücker,Toshifumi Matsuyama,Alex Grossman,Thomas M. Kündig,Julia Potter,Arda Shahinian,Andrew Wakeham,Bruce Patterson,Pamela S. Ohashi,Tak W. Mak +9 more
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TLDR
Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes that is essential for the function and homeostasis of both mature B and mature T lymphocytes.Abstract:
Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.read more
Citations
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Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
Ash A. Alizadeh,Michael B. Eisen,R. Eric Davis,Izidore S. Lossos,Andreas Rosenwald,Jennifer C. Boldrick,Hajeer Sabet,Truc Tran,Xin Yu,John Powell,Liming Yang,Gerald E. Marti,Troy Moore,James I. Hudson,Li-Sheng Lu,David B. Lewis,Robert Tibshirani,Gavin Sherlock,Wing C. Chan,Timothy C. Greiner,Dennis D. Weisenburger,James O. Armitage,Roger A. Warnke,Ronald Levy,Wyndham H. Wilson,M. R. Grever,John C. Byrd,David Botstein,Patrick O. Brown,Louis M. Staudt +29 more
TL;DR: It is shown that there is diversity in gene expression among the tumours of DLBCL patients, apparently reflecting the variation in tumour proliferation rate, host response and differentiation state of the tumour.
Journal ArticleDOI
IRF family of transcription factors as regulators of host defense
TL;DR: Their functional roles, through interactions with their own or other members of the family of transcription factors, are becoming clearer in the regulation of host defense, such as innate and adaptive immune responses and oncogenesis.
Journal ArticleDOI
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
Kenya Honda,Tadatsugu Taniguchi +1 more
TL;DR: The interferon-regulatory factor family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons but has now been shown to have functionally diverse roles in the regulation of the immune system.
Journal ArticleDOI
Plasma cell differentiation requires the transcription factor XBP-1
Andreas M. Reimold,Neal N. Iwakoshi,John P. Manis,Prashanth Vallabhajosyula,Eva Szomolanyi-Tsuda,Ellen M. Gravallese,Daniel S. Friend,Michael J. Grusby,Frederick W. Alt,Laurie H. Glimcher +9 more
TL;DR: XBP-1 transcripts were rapidly upregulated in vitro by stimuli that induce plasma-cell differentiation, and were found at high levels in plasma cells from rheumatoid synovium, and when introduced into B-lineage cells, XBP- 1 initiated plasma- cell differentiation.
Journal ArticleDOI
TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY
TL;DR: The significance of type I interferons (IFN-α/β) in biology and medicine renders research on their activities continuously relevant to our understanding of normal and abnormal (auto) immune responses as mentioned in this paper.
References
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Journal ArticleDOI
Differential T cell costimulatory requirements in CD28-deficient mice
Arda Shahinian,Klaus Pfeffer,Kelvin P. Lee,Thomas M. Kündig,Kenji Kishihara,Andrew Wakeham,Kazuhiro Kawai,Pamela S. Ohashi,Craig B. Thompson,Tak W. Mak +9 more
TL;DR: CD28 is not required for all T cell responses in vivo, suggesting that alternative costimulatory pathways may exist.
Journal ArticleDOI
Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
Dennis M. Willerford,Jianzhu Chen,Judith A. Ferry,Laurie Davidson,Averil Ma,Averil Ma,Frederick W. Alt,Frederick W. Alt +7 more
TL;DR: Interleukin-2 receptor alpha chain expression occurs at specific stages of early T and B lymphocyte development and is induced upon activation of mature lymphocytes, probably by influencing the balance between clonal expansion and cell death following lymphocyte activation.
Journal ArticleDOI
Requirement for transcription factor IRF-1 in NO synthase induction in macrophages.
Ryutaro Kamijo,Hisashi Harada,Toshifumi Matsuyama,Maarten C. Bosland,J. Gerecitano,Deborah Shapiro,Junming Le,S. I. Koh,Tohru Kimura,Shawn J. Green,T. W. Mak,Tadatsugu Taniguchi,Jan Vilcek +12 more
TL;DR: Macrophages from mice with a targeted disruption of the IFN regulatory factor-1 (IRF-1) gene produced little or no NO and synthesized barely detectable iNOS messenger RNA in response to stimulation, and infection with Mycobacterium bovis was more severe in IRf-1-/- mice than in wild-type mice.
Journal ArticleDOI
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1
Nobuyuki Tanaka,Masahiko Ishihara,Motoo Kitagawa,Hisashi Harada,Tohru Kimura,Toshifumi Matsuyama,Marc S. Lamphier,Shinichi Aizawa,Tak W. Mak,Tadatsugu Taniguchi +9 more
TL;DR: It is reported that embryonic fibroblasts from mice with a null mutation in the IRF-1 gene can be transformed by expression of an activated c-Ha-ras oncogene and could be a critical determinant of oncogen-induced cell transformation or apoptosis.
Journal ArticleDOI
Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
TL;DR: The cloning and characterization of Pip is described, a lymphoid-specific protein that is most likely NF-EM5.1 that binds the composite element only in the presence of PU.1 and exhibits a high degree of homology to the DNA-binding domains of members of the interferon regulatory factor (IRF) family.