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Harro Seelaar
Researcher at Erasmus University Rotterdam
Publications - 112
Citations - 11447
Harro Seelaar is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Frontotemporal dementia & Medicine. The author has an hindex of 25, co-authored 63 publications receiving 9260 citations. Previous affiliations of Harro Seelaar include Erasmus University Medical Center.
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Journal ArticleDOI
Proteomics of the dentate gyrus reveals semantic dementia specific molecular pathology
Merel O. Mol,Suzanne S. M. Miedema,Shami Melhem,Kai Li,Frank Koopmans,Harro Seelaar,Kurt Gottmann,Volkmar Lessmann,Netherlands Brain Bank,August B. Smit,John C. van Swieten,Jeroen van Rooij +11 more
TL;DR: In this article , the authors carried out laser capture microdissection of the dentate gyrus of 15 semantic dementia (SD) patients and 17 non-demented controls, and assessed relative protein abundance changes by label-free quantitative mass spectrometry.
Posted ContentDOI
The behavioral variant of Alzheimer’s disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex
Ellen H. Singleton,Yolande A.L. Pijnenburg,P. Gami-Patel,B. D. C. Boon,Femke H. Bouwman,Janne M. Papma,Harro Seelaar,P. Scheltens,Lea T. Grinberg,Lea T. Grinberg,Salvatore Spina,Alissa L. Nana,Gil D. Rabinovici,William W. Seeley,William W. Seeley,Rik Ossenkoppele,Rik Ossenkoppele,Anke A. Dijkstra +17 more
TL;DR: In this article, a selective loss of Von Economo Neurons (VENs) and phylogenetically related neurons have been observed in behavioral variant frontotemporal dementia (bvFTD) and several psychiatric diseases.
Journal ArticleDOI
Exploring Abstract Semantic Associations in the Frontotemporal Dementia Spectrum in a Dutch Population.
Jackie M. Poos,E. van den Berg,E Visch-Brink,Willem S. Eikelboom,Sanne Franzen,J. van Hemmen,Yolande A.L. Pijnenburg,Djaina Satoer,Elise G.P. Dopper,J. C. van Swieten,Janne M. Papma,Harro Seelaar,Lize C. Jiskoot,Lize C. Jiskoot +13 more
TL;DR: In this article, the Test Relaties Abstracte Concepten (TRACE) test for abstract semantic knowledge in frontotemporal dementia (FTD) was administered in patients with behavioral variant FTD (bvFTD), nonfluent variant (nfvPPA), log openic variant (lvPPA), and semantic variant primary progressive aphasia (svPPA).
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Antibodies Associated With Autoimmune Encephalitis in Patients With Presumed Neurodegenerative Dementia
Anna E M Bastiaansen,Robin van Steenhoven,Wiesje M. van der Flier,Charlotte E. Teunissen,Esther de Graaff,Mariska M.P. Nagtzaam,Manuela Paunovic,Suzanne C Franken,Marco W.J. Schreurs,Frank Leypoldt,Peter A.E. Sillvis Smitt,Juna M. de Vries,Harro Seelaar,John C. van Swieten,Frank Jan de Jong,Yolande A.L. Pijnenburg,Maarten J. Titulaer +16 more
TL;DR: In this paper , the frequency of neuronal antibodies in patients with presumed neurodegenerative dementia and describe the clinical characteristics of the patients with neuronal antibodies were detected in 7 patients (0.8%), including anti-IgLON5, anti-LGI1 (n = 2), anti-DPPX, and anti-NMDAR.
Journal ArticleDOI
FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation
Dailu Chen,Aleksandra Wosztyl,Vishruth Mullapudi,Sofia Bali,Jaime Vaquer-Alicea,Shami Melhem,Harro Seelaar,John C. van Swieten,Marc I. Diamond,Lukasz A. Joachimiak +9 more
TL;DR: In this article , the structural mechanism for how an FTD-tau S320F mutation drives spontaneous aggregation was described, integrating data from in vitro, in silico and cellular experiments.