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Harro Seelaar
Researcher at Erasmus University Rotterdam
Publications - 112
Citations - 11447
Harro Seelaar is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Frontotemporal dementia & Medicine. The author has an hindex of 25, co-authored 63 publications receiving 9260 citations. Previous affiliations of Harro Seelaar include Erasmus University Medical Center.
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Cognitive Composites for Genetic Frontotemporal Dementia: GENFI-Cog
Jackie M. Poos,Katrina M. Moore,Jennifer M. Nicholas,Lucy L. Russell,Georgia Peakman,Rhian S Convery,Lize C. Jiskoot,Emma L. van der Ende,Esther van den Berg,Janne M. Papma,Harro Seelaar,Yolande A.L. Pijnenburg,Fermin Moreno,Raquel Sánchez-Valle,Barbara Borroni,Robert Laforce,Mario Masellis,Carmela Tartaglia,Caroline Graff,Daniela Galimberti,James B. Rowe,Elizabeth Finger,Matthis Synofzik,Rik Vandenberghe,Alexandre de Mendonça,Pietro Tiraboschi,Isabel Santana,Simon Ducharme,Christopher C Butler,Alexander Gerhard,Johannes Levin,Adrian Danek,Markus Otto,Isabel Le Ber,Florence Pasquier,John C. van Swieten,Jonathan D. Rohrer +36 more
TL;DR: The GENFI-Cog composites have potential as cognitive endpoints for upcoming clinical trials in frontotemporal dementia (FTD) as discussed by the authors, which resulted in substantially lower estimated sample sizes to detect a treatment effect than the individual cognitive tests.
Journal ArticleDOI
Differential linguistic features of verbal fluency in behavioral variant frontotemporal dementia and primary progressive aphasia.
Esther van den Berg,J. C. M. Dijkzeul,Jackie M. Poos,Willem S. Eikelboom,Judy van Hemmen,Sanne Franzen,Frank Jan de Jong,Egp Dopper,Jet M.J. Vonk,Janne M. Papma,Djaina Satoer,Lize C. Jiskoot,Harro Seelaar +12 more
TL;DR: The authors examined qualitative, linguistic features of verbal fluency in 137 patients with behavioral variant (bv)FTD (n = 50), or primary progressive aphasia (PPA) and 25 control participants.
Journal ArticleDOI
Genome-wide association study of frontotemporal dementia identifies a C9ORF72 haplotype with a median of 12-G4C2 repeats that predisposes to pathological repeat expansions
Lianne M. Reus,Iris E. Jansen,Iris E. Jansen,Merel O. Mol,Fred van Ruissen,Jeroen van Rooij,Natasja M. van Schoor,Niccolò Tesi,Niccolò Tesi,Marcel J. T. Reinders,Martijn Huisman,Martijn Huisman,Henne Holstege,Pieter Jelle Visser,Pieter Jelle Visser,Pieter Jelle Visser,Sterre C M de Boer,Marc Hulsman,Shahzad Ahmad,Najaf Amin,André G. Uitterlinden,Arfan Ikram,Cornelia M. van Duijn,Harro Seelaar,Inez H.G.B. Ramakers,Frans R.J. Verhey,Aad van der Lugt,Jurgen A.H.R. Claassen,Geert Jan Biessels,Peter Paul De Deyn,Philip Scheltens,Wiesje M. van der Flier,Wiesje M. van der Flier,John C. van Swieten,Yolande A.L. Pijnenburg,Sven J. van der Lee +35 more
TL;DR: In this article, two rare genetic variants nearby C9ORF72 were associated with frontotemporal dementia (FTD) in the discovery (rs147211831: OR = 4.8, P = 9.2 × 10−9, rs117204439: OR ≤ 4.9, P ≤ 6.0 × 10 −9) and replication analysis.
Journal ArticleDOI
Structural MRI predicts clinical progression in presymptomatic genetic frontotemporal dementia: findings from the GENetic Frontotemporal dementia Initiative cohort
Martina Bocchetta,Emily Todd,Arabella Bouzigues,David M. Cash,Jennifer M. Nicholas,Rhian S Convery,Lucy L. Russell,David L. Thomas,Ian B. Malone,Juan Eugenio Iglesias,John C. van Swieten,Lize C. Jiskoot,Harro Seelaar,S. Borroni,Daniela Galimberti,Raquel Sánchez-Valle,Robert Laforce,Fermin Moreno,Matthis Synofzik,Caroline Graff,Mario Masellis,Maria Carmela Tartaglia,James B. Rowe,Rik Vandenberghe,Elizabeth Finger,Fabrizio Tagliavini,Alexandre de Mendonça,Isabel Santana,Christopher C Butler,Simon Ducharme,Alexander Gerhard,Adrian Danek,Johannes Levin,Markus Otto,Sandro Sorbi,Isabelle Le Ber,Florence Pasquier,Jonathan D. Rohrer,A. Esteve,Annabel Nelson,Carolin Heller,Caroline V. Greaves,Hanya Benotmane,Henrik Zetterberg,Imogen Swift,Kiran Samra,Rachelle Shafei,C. Timberlake,Thomas E. Cope,Timothy Rittman,Alberto Benussi,Enrico Premi,Roberto Gasparotti,Silvana Archetti,Stefano Gazzina,Valentina Cantoni,Andrea Arighi,Chiara Fenoglio,Elio Scarpini,Giorgio G. Fumagalli,Vittoria Borracci,Giacomina Rossi,Giorgio Giaccone,Giuseppe Di Fede,Paola Caroppo,Pietro Tiraboschi,Sara Prioni,Veronica Redaelli,David F. Tang-Wai,Ekaterina Rogaeva,Miguel Castelo-Branco,Morris Freedman,Ron Keren,Sandra E. Black,Sara Mitchell,Christen Shoesmith,Robart Bartha,Rosa Rademakers,Jackie M. Poos,Janne M. Papma,Lucia A. A. Giannini,Rick van Minkelen,Yolande A.L. Pijnenburg,Benedetta Nacmias,Camilla Ferrari,Cristina Polito,Gemma Lombardi,Valentina Bessi,Michele Veldsman,Christin Andersson,Håkan Thonberg,Linn Öijerstedt,Vesna Jelic,Paul Thompson,Tobias Langheinrich,Albert Lladó,A. Antonelli,Jaume Olives,Mircea Balasa,Núria Bargalló,Sergi Borrego-Écija,Ana Verdelho,Carolina Maruta,Catarina Beatriz Silva Ferreira,Gabriel Miltenberger,Frederico Simões do Couto,Alazne Gabilondo,Ana Gorostidi,Jorge Villanua,Marta Cañada,Mikel Tainta,Miren Zulaica,Myriam Barandiaran,Patrícia Alves,Benjamin Bender,Carlo Wilke,Lisa Graf,Annick Vogels,Mathieu Vandenbulcke,Philip Van Damme,Rose Bruffaerts,Koen Poesen,Pedro Rosa-Neto,Serge Gauthier,Agnès Camuzat,Alexis Brice,Anne Bertrand,Aurélie Funkiewiez,Daisy Rinaldi,Dario Saracino,Olivier Colliot,Sabrina Sayah,Catharina Prix,Elisabeth Wlasich,Olivia Wagemann,Sandra V. Loosli,Sonja Schönecker,Tobias Hoegen,Jolina Lombardi,Sarah Anderl-Straub,Adeline Rollin,Grégory Kuchcinski,Maxime Bertoux,Thibaud Lebouvier,Vincent Deramecourt,Beatriz Santiago,Diana Duro,Maria João Leitão,Maria Rosário Almeida,Miguel Tábuas-Pereira,Sónia Afonso +150 more
TL;DR: In this article , the authors identify whether baseline MRI-based grey and white matter abnormalities are associated with different clinical progression profiles in presymptomatic mutation carriers in the GENetic Frontotemporal dementia Initiative.
Journal ArticleDOI
Cognitive composites for genetic frontotemporal dementia: GENFI-Cog
Jackie M. Poos,Katrina M. Moore,Jennifer M. Nicholas,Lucy L. Russell,Georgia Peakman,Rhian S Convery,Lize C. Jiskoot,Emma L. van der Ende,Esther van den Berg,Janne M. Papma,Harro Seelaar,Yolande A.L. Pijnenburg,Fermin Moreno,Raquel Sánchez-Valle,S. Borroni,Robert Laforce,Mario Masellis,Carmela Tartaglia,Caroline Graff,Daniela Galimberti,James B. Rowe,Elizabeth Finger,Matthis Synofzik,Rik Vandenberghe,Alexandre de Mendonça,Pietro Tiraboschi,Isabel Santana,Simon Ducharme,Christopher C Butler,Alexander Gerhard,Johannes Levin,Adrian Danek,Markus Otto,Isabelle Le Ber,Florence Pasquier,John C. van Swieten,Jonathan D. Rohrer,Arabella Bouzigues,Martin N. Rossor,Nick C. Fox,Jason D. Warren,Martina Bocchetta,Imogen Swift,Rachelle Shafei,Carolin Heller,Emily Todd,David M. Cash,Ione O.C. Woollacott,Henrik Zetterberg,Annabel Nelson,Rita Guerreiro,Jose Bras,David L. Thomas,Simon Head,Lieke H.H. Meeter,Jessica L. Panman,Rick van Minkelen,Myriam Barandiaran,Begoña Indakoetxea,Alazne Gabilondo,Mikel Tainta,Ana Gorostidi,Miren Zulaica,Alina Díez,Jorge Villanua,Sergi Borrego-Écija,Jaume Olives,Albert Lladó,Mircea Balasa,A. Antonelli,Núria Bargalló,Enrico Premi,Stefano Gazzina,Roberto Gasparotti,Silvana Archetti,Sandra E. Black,Sara Mitchell,Ekaterina Rogaeva,Morris Freedman,Ron Keren,David F. Tang-Wai,Håkan Thonberg,Linn Öijerstedt,Christin Andersson,Vesna Jelic,Andrea Arighi,Chiara Fenoglio,Elio Scarpini,Giorgio G. Fumagalli,Thomas E. Cope,C. Timberlake,Timothy Rittman,Christen Shoesmith,Robart Bartha,Rosa Rademakers,Carlo Wilke,Hans-Otto Karnarth,Benjamin Bender,Rose Bruffaerts,Philip Vandamme,Mathieu Vandenbulcke,Catarina Beatriz Silva Ferreira,Gabriel Miltenberger,Carolina Maruta,Ana Verdelho,Sónia Afonso,Ricardo Taipa,Paola Caroppo,Giuseppe Di Fede,Giorgio Giaccone,Sara Prioni,Veronica Redaelli,Giacomina Rossi,Diana Duro,Maria Rosário Almeida,Miguel Castelo-Branco,Maria João Leitão,Miguel Tábuas-Pereira,Beatriz Santiago,Serge Gauthier,Pedro Rosa-Neto,Michele Veldsman,Paul Thompson,Tobias Langheinrich,Catharina Prix,Tobias Hoegen,Elisabeth Wlasich,Sandra V. Loosli,Sonja Schonecker,Sarah Anderl-Straub,Jolina Lombardi,Alberto Benussi,Valentina Cantoni,Maxime Bertoux,Anne Bertrand,Alexis Brice,Agnès Camuzat,Olivier Colliot,Sabrina Sayah,Aurélie Funkiewiez,Daisy Rinaldi,Gemma Lombardi,Benedetta Nacmias,Dario Saracino,Valentina Bessi,Camilla Ferrari,Marta Cañada,Vincent Deramecourt,Grégory Kuchcinski,Thibaud Lebouvier,Sebastien Ourselin,Cristina Polito,Adeline Rollin +152 more
TL;DR: In this paper , a standardized neuropsychological test battery covering six cognitive domains was completed by 69 C9orf72, 41 GRN, and 28 MAPT mutation carriers with CDR® plus NACC-FTLD ≥ 0.5 and 275 controls.