Harro Seelaar

TL;DR: In this article , a microflow LC PRM-MS set-up targeting 15 synaptic proteins: AP-2 complex subunit beta, complexin-2, beta-synuclein, gamma-synulein, 14-3-3 proteins (eta, epsilon, zeta/delta), neurogranin, Rab GDP dissociation inhibitor alpha (Rab GDI alpha), syntaxin-1B, syntaxin 7, and PEBP-1, with three other proteins increased in symptomatic MAPT mutation carriers compared with the other genetic groups (AP-2 subunit β, complex-unit complex-subunit gamma-sub-unit-β, and 14- 3-3 zeta-delta).

TL;DR: Overall, the MR study did not support the direct causal association between LTL and the ALS risk in neither population, but provided suggestive evidence for the mediation role of LDL or TC on the influence of L TL and ALS in the European population.

TL;DR: In this article , a microflow LC PRM-MS set-up targeting 15 synaptic proteins: AP-2 complex subunit beta, complexin-2, beta-synuclein, gamma-synulein, 14-3-3 proteins (eta, epsilon, zeta/delta), neurogranin, Rab GDP dissociation inhibitor alpha (Rab GDI alpha), syntaxin-1B, syntaxin 7, and PEBP-1, with three other proteins increased in symptomatic MAPT mutation carriers compared with the other genetic groups (AP-2 subunit β, complex-unit complex-subunit gamma-sub-unit-β, and 14- 3-3 zeta-delta).

TL;DR: In this article , the authors evaluated the possible polygenic architecture in a large series of families, to assess if genetic testing of familial early-onset Alzheimer's disease (EOAD) could be expanded.

TL;DR: In this article , contrastive trajectory inference (cTI) was used to identify data-driven disease stages in a heterogeneous sample combining different mutations and disease stages of genetic FTD using only MRI metrics.