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Harro Seelaar
Researcher at Erasmus University Rotterdam
Publications - 112
Citations - 11447
Harro Seelaar is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Frontotemporal dementia & Medicine. The author has an hindex of 25, co-authored 63 publications receiving 9260 citations. Previous affiliations of Harro Seelaar include Erasmus University Medical Center.
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Journal ArticleDOI
Apolipoprotein L1 is increased in frontotemporal lobar degeneration post-mortem brain but not in ante-mortem cerebrospinal fluid
Yanaika S. Hok-A-Hin,Anke A. Dijkstra,Alberto Rábano,Jeroen J.M. Hoozemans,Lucia Castillo,Harro Seelaar,John C. van Swieten,Yolande A.L. Pijnenburg,Charlotte E. Teunissen,Marta Del Campo +9 more
TL;DR: In this article , the Apolipoprotein L1 (APOL1) levels in CSF from frontal-temporal lobar degeneration (FTD) patients were analyzed in the frontal cortex of FTLD and non-demented controls.
Journal ArticleDOI
Structural brain splitting is a hallmark of Granulin-related frontotemporal dementia
Stefano Gazzina,Mario Grassi,Enrico Premi,Antonella Alberici,Alberto Benussi,Silvana Archetti,Roberto Gasparotti,Martina Bocchetta,David M. Cash,Emily Todd,Georgia Peakman,Rhian S Convery,John C. van Swieten,Lize C. Jiskoot,Harro Seelaar,Raquel Sánchez-Valle,Fermin Moreno,Robert Laforce,Caroline Graff,Matthis Synofzik,Daniela Galimberti,James B. Rowe,Mario Masellis,Maria Carmela Tartaglia,Elizabeth Finger,Rik Vandenberghe,Alexandre de Mendonça,Fabrizio Tagliavini,Christopher C Butler,Isabel Santana,Alexander Gerhard,Isabelle Le Ber,Florence Pasquier,Simon Ducharme,Johannes Levin,Adrian Danek,Sandro Sorbi,Markus Otto,Jonathan D. Rohrer +38 more
TL;DR: In this paper , the authors applied a minimum spanning tree plus an efficiency cost optimization approach to cortical thickness data in order to test whether graph theory measures could identify global or local impairment of connectivity in the presymptomatic phase.
Journal ArticleDOI
Genetic forms of primary progressive aphasia within the GENetic Frontotemporal dementia Initiative (GENFI) cohort: comparison with sporadic primary progressive aphasia
Kiran Samra,Amy Macdougall,Arabella Bouzigues,Martina Bocchetta,David M. Cash,Caroline V. Greaves,Rhian S Convery,Chris J.D. Hardy,John C. van Swieten,Harro Seelaar,Lize C. Jiskoot,Fermin Moreno,Raquel Sánchez-Valle,Robert Laforce,Caroline Graff,Mario Masellis,Maria Carmela Tartaglia,James B. Rowe,S. Borroni,Elizabeth Finger,Matthis Synofzik,Daniela Galimberti,Rik Vandenberghe,Alexandre de Mendonça,Christopher C Butler,Alexander Gerhard,Simon Ducharme,Isabelle Le Ber,Isabel Santana,Florence Pasquier,Johannes Levin,Markus Otto,Sandro Sorbi,Jason D. Warren,Jonathan D. Rohrer,Lucy L. Russell +35 more
TL;DR: In this paper , the clinical, cognitive and imaging phenotype of the genetic forms of primary progressive aphasia in comparison to the canonical nonfluent, semantic and logopenic subtypes seen in sporadic disease was investigated.
Journal ArticleDOI
Language impairment in the genetic forms of behavioural variant frontotemporal dementia
Kiran Samra,Amy Macdougall,Arabella Bouzigues,Martina Bocchetta,David M. Cash,Caroline V. Greaves,Rhian S Convery,John C. van Swieten,Harro Seelaar,Lize C. Jiskoot,Fermin Moreno,Raquel Sánchez-Valle,Robert Laforce,Caroline Graff,Mario Masellis,Maria Carmela Tartaglia,James B. Rowe,S. Borroni,Elizabeth Finger,Matthis Synofzik,Daniela Galimberti,Rik Vandenberghe,Alexandre de Mendonça,Christopher C Butler,Alexander Gerhard,Simon Ducharme,Isabelle Le Ber,Pietro Tiraboschi,Isabel Santana,Florence Pasquier,Johannes Levin,Markus Otto,Sandro Sorbi,Jonathan D. Rohrer,Lucy L. Russell,Annabel Nelson,David L. Thomas,Emily Todd,Hanya Benotmane,Jennifer M. Nicholas,Rachelle Shafei,C. Timberlake,Thomas E. Cope,Timothy Rittman,Alberto Benussi,Enrico Premi,Roberto Gasparotti,Silvana Archetti,Stefano Gazzina,Valentina Cantoni,Andrea Arighi,Chiara Fenoglio,Elio Scarpini,Giorgio G. Fumagalli,Vittoria Borracci,Giacomina Rossi,Giorgio Giaccone,Giuseppe Di Fede,Paola Caroppo,Sara Prioni,Veronica Redaelli,David F. Tang-Wai,Ekaterina Rogaeva,Miguel Castelo-Branco,Morris Freedman,Ron Keren,Sandra E. Black,Sara Mitchell,Christen Shoesmith,Robart Bartha,Rosa Rademakers,Jackie M. Poos,Janne M. Papma,Lucia A. A. Giannini,Rick van Minkelen,Yolande A.L. Pijnenburg,Benedetta Nacmias,Camilla Ferrari,Cristina Polito,Gemma Lombardi,Valentina Bessi,Michele Veldsman,Christin Andersson,Håkan Thonberg,Linn Öijerstedt,Vesna Jelic,Paul Thompson,Tobias Langheinrich,Albert Lladó,A. Antonelli,Jaume Olives,Mircea Balasa,Núria Bargalló,Sergi Borrego-Écija,Ana Verdelho,Carolina Maruta,Catarina Beatriz Silva Ferreira,Gabriel Miltenberger,Frederico Simões do Couto,Alazne Gabilondo,Ana Gorostidi,Jorge Villanua,Marta Cañada,Mikel Tainta,Miren Zulaica,Myriam Barandiaran,Patrícia Alves,Benjamin Bender,Carlo Wilke,Lisa Graf,Annick Vogels,Mathieu Vandenbulcke,Philip Van Damme,Rose Bruffaerts,Koen Poesen,Pedro Rosa-Neto,Serge Gauthier,Agnès Camuzat,Alexis Brice,Anne Bertrand,Aurélie Funkiewiez,Daisy Rinaldi,Dario Saracino,Olivier Colliot,Sabrina Sayah,Catharina Prix,Elisabeth Wlasich,Olivia Wagemann,Sandra V. Loosli,Sonja Schönecker,Tobias Hoegen,Jolina Lombardi,Sarah Anderl-Straub,Adeline Rollin,Grégory Kuchcinski,Maxime Bertoux,Thibaud Lebouvier,Vincent Deramecourt,Beatriz Santiago,Diana Duro,Maria João Leitão,Maria Rosário Almeida,Miguel Tábuas-Pereira,Sónia Afonso +143 more
TL;DR: For example, this paper found that 76% of the genetic bvFTD cohort had impairment in at least one language symptom: 83% C9orf72 , 80% MAPT and 56% GRN mutation carriers.
Journal ArticleDOI
Cortical iron accumulation in MAPT ‐ and C9orf 72‐associated frontotemporal lobar degeneration
Lucia A. A. Giannini,Marjolein Bulk,Boyd Kenkhuis,A. Rajicic,Shami Melhem,Ingrid M. Hegeman-Kleinn,L. Bossoni,Ernst Suidgeest,Elise G.P. Dopper,John C. van Swieten,Louise van der Weerd,Harro Seelaar +11 more
TL;DR: In this article , the authors investigated the occurrence of cortical iron accumulation in FTLD-MAPT and FTLD−C9orf72, and found that cortical iron was associated with the severity of proteinopathy (tau or TDP‐43) and neuronal degeneration.