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Harro Seelaar
Researcher at Erasmus University Rotterdam
Publications - 112
Citations - 11447
Harro Seelaar is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Frontotemporal dementia & Medicine. The author has an hindex of 25, co-authored 63 publications receiving 9260 citations. Previous affiliations of Harro Seelaar include Erasmus University Medical Center.
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Journal ArticleDOI
The clinical and pathological phenotype of C9ORF72 hexanucleotide repeat expansions
Javier Simón-Sánchez,Elise G.P. Dopper,Elise G.P. Dopper,Petra E. Cohn-Hokke,Renate K. Hukema,Nayia Nicolaou,Harro Seelaar,J. Roos A. de Graaf,Inge de Koning,Natasja M. van Schoor,Dorly J. H. Deeg,Marion Smits,Joost Raaphorst,Leonard H. van den Berg,Helenius J. Schelhaas,Christine E. M. de Die-Smulders,Danielle Majoor-Krakauer,Annemieke J.M. Rozemuller,Rob Willemsen,Yolande A.L. Pijnenburg,Peter Heutink,John C. van Swieten,John C. van Swieten +22 more
TL;DR: Investigation of clinical and neuropathological characteristics of hexanucleotide repeat expansions in C9orf72 in a large cohort of Dutch patients with frontotemporal dementia found neuronal and glial inclusions, and dystrophic neurites containing transactive response DNA binding protein.
Journal ArticleDOI
FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration.
Hazel Urwin,Keith A. Josephs,Jonathan D. Rohrer,Ian R. A. Mackenzie,Manuela Neumann,Astrid Authier,Harro Seelaar,John C. van Swieten,Jeremy M Brown,Peter Johannsen,Jørgen E. Nielsen,Ida E. Holm,Dennis W. Dickson,Rosa Rademakers,Neill R. Graff-Radford,Joseph E. Parisi,Ronald C. Petersen,Kimmo J. Hatanpaa,Charles L. White,Myron F. Weiner,Felix Geser,Vivianna M. Van Deerlin,John Q. Trojanowski,Bruce L. Miller,William W. Seeley,Julie van der Zee,Julie van der Zee,Samir Kumar-Singh,Samir Kumar-Singh,Sebastiaan Engelborghs,Peter Paul De Deyn,Christine Van Broeckhoven,Christine Van Broeckhoven,Eileen H. Bigio,Han Xiang Deng,Glenda M. Halliday,Jillian J. Kril,David G. Munoz,David M. A. Mann,Stuart Pickering-Brown,Valerie Doodeman,Gary Adamson,Shabnam Ghazi-Noori,Elizabeth M. C. Fisher,Janice L. Holton,Tamas Revesz,Martin N. Rossor,John Collinge,Simon Mead,Adrian M. Isaacs +49 more
TL;DR: The first comprehensive analysis of these FTLD-FUS cases is presented, in terms of neuropathology, genetics, demographics and clinical data, suggesting that the full complement of FTLD pathologies is yet to be elucidated.
Journal ArticleDOI
Distinct genetic forms of frontotemporal dementia.
Harro Seelaar,Wouter Kamphorst,Sonia M. Rosso,Asma Azmani,R. Masdjedi,I. de Koning,J. A. Maat-Kievit,Burcu Anar,L. Donker Kaat,Guido J. Breedveld,Dennis Dooijes,J. M. Rozemuller,Iraad F. Bronner,Patrizia Rizzu,J. C. van Swieten +14 more
TL;DR: Future genetic studies need to identify genetic defects in at least two distinct familial forms of frontotemporal dementia (FTD) with unknown genetic defects: frontotamporal lobe degeneration with ubiquitin-positive inclusions with hippocampal sclerosis and frontotmporal lobedegeneration with motor neuron disease.
Journal ArticleDOI
Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.
Katrina M. Moore,Jennifer M. Nicholas,Murray Grossman,Corey T. McMillan,David J. Irwin,Lauren Massimo,Vivianna M. Van Deerlin,Jason D. Warren,Nick C. Fox,Martin N. Rossor,Simon Mead,Martina Bocchetta,Bradley F. Boeve,David S. Knopman,Neill Graff-Radford,Leah K. Forsberg,Rosa Rademakers,Zbigniew K. Wszolek,John C. van Swieten,Lize C. Jiskoot,Lieke H.H. Meeter,Elise G.P. Dopper,Janne M. Papma,Julie S. Snowden,Jennifer A. Saxon,Matthew Jones,Stuart Pickering-Brown,Isabelle Le Ber,Agnès Camuzat,Alexis Brice,Paola Caroppo,Roberta Ghidoni,Michela Pievani,Luisa Benussi,Giuliano Binetti,Bradford C. Dickerson,Diane Lucente,Samantha Krivensky,Caroline Graff,Linn Öijerstedt,Marie Fallström,Håkan Thonberg,Nupur Ghoshal,John C. Morris,Barbara Borroni,Alberto Benussi,Alessandro Padovani,Daniela Galimberti,Elio Scarpini,Giorgio G. Fumagalli,Giorgio G. Fumagalli,Ian R. Mackenzie,Ging-Yuek Robin Hsiung,Pheth Sengdy,Adam L. Boxer,Howie Rosen,Joanne Taylor,Matthis Synofzik,Matthis Synofzik,Carlo Wilke,Carlo Wilke,Patricia Sulzer,Patricia Sulzer,John R. Hodges,Glenda M. Halliday,John B.J. Kwok,Raquel Sánchez-Valle,Albert Lladó,Sergi Borrego-Écija,Isabel Santana,Maria Rosário Almeida,Miguel Tábuas-Pereira,Fermin Moreno,Myriam Barandiaran,Begoña Indakoetxea,Johannes Levin,Johannes Levin,Adrian Danek,James B. Rowe,Thomas E. Cope,Markus Otto,Sarah Anderl-Straub,Alexandre de Mendonça,Carolina Maruta,Mario Masellis,Sandra E. Black,Philippe Couratier,Géraldine Lautrette,Edward D. Huey,Sandro Sorbi,Benedetta Nacmias,Robert Laforce,Marie Pier L. Tremblay,Rik Vandenberghe,Philip Van Damme,Philip Van Damme,Emily Rogalski,Sandra Weintraub,Alexander Gerhard,Alexander Gerhard,Chiadi U. Onyike,Simon Ducharme,Sokratis G. Papageorgiou,Adeline Su Lyn Ng,Amy Brodtmann,Elizabeth Finger,Rita Guerreiro,Jose Bras,Jonathan D. Rohrer,Carolin Heller,Rhian S Convery,Ione O.C. Woollacott,Rachelle Shafei,Jonathan Graff-Radford,David T.W. Jones,Christina Dheel,Rodolfo Savica,Maria I. Lapid,Matt Baker,Julie A. Fields,Ralitza H. Gavrilova,Kimiko Domoto-Reilly,Jackie M. Poos,Emma L. van der Ende,Jessica L. Panman,Laura Donker Kaat,Harro Seelaar,Anna Richardson,Giovanni B. Frisoni,Anna Mega,Silvia Fostinelli,Huei Hsin Chiang,Antonella Alberici,Andrea Arighi,Chiara Fenoglio,Hilary W. Heuer,Bruce L. Miller,Anna Karydas,Jamie Fong,Maria João Leitão,Beatriz Santiago,Diana Duro,Carlos Ferreira,Alazne Gabilondo,Maria de Arriba,Mikel Tainta,Miren Zulaica,Catarina S. Ferreira,Elisa Semler,Albert C. Ludolph,Bernhard Landwehrmeyer,Alexander E Volk,Gabriel Miltenberger,Ana Verdelho,Sónia Afonso,Maria Carmela Tartaglia,Morris Freedman,Ekaterina Rogaeva,Camilla Ferrari,Irene Piaceri,Valentina Bessi,Gemma Lombardi,Frédéric St-Onge,Marie Claire Doré,Rose Bruffaerts,Mathieu Vandenbulcke,Jan Van den Stock,M.-Marsel Mesulam,Eileen H. Bigio,Christos Koros,John Papatriantafyllou,Christos Kroupis,Leonidas Stefanis,Christien Shoesmith,Erik Robertson,Giovanni Coppola,Eliana Marisa Ramos,Daniel H. Geschwind +177 more
TL;DR: An international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72 to investigate the extent to which variability in age at onset and at death could be accounted for by family membership and the specific mutation carried.
Journal ArticleDOI
Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration.
Harro Seelaar,Kirsten Y. Klijnsma,Inge de Koning,Aad van der Lugt,Wang Zheng Chiu,Asma Azmani,Annemieke J.M. Rozemuller,John C. van Swieten +7 more
TL;DR: The existence of this pathological subtype can be predicted with reasonable certainty by age at onset ≤40 years, negative family history, bvFTD and caudate atrophy on MRI, and the newly identified FTLD-FUS has a frequency of 11% inFTLD-U and an estimated frequency of three percent in the clinical FTD cohort.