Helma Dc Schwenen

TL;DR: A novel mechanism of acquired cisplatin resistance in breast cancer cells is identified through the induction of FOXM1, a key regulator of cell proliferation and is overexpressed in many forms of primary cancers, leading to uncontrolled cell division and genomic instability.

TL;DR: The Transcription Factor Encyclopedia (TFe), a new web-based compendium of mini review articles on transcription factors (TFs) that is founded on the principles of open access and collaboration, is presented.

TL;DR: A better understanding of the mechanism by which FOXO and FOXM1 are regulated, as well as their roles in drug sensitivity and resistance, may render these proteins crucial prognostic markers and therapeutic targets for breast cancer and other malignancies.

TL;DR: To analyze estimation behavior, two main characteristics were investigated: the temporal changes of the estimation results, called temporal sensitivity, was evaluated and the standard deviation over time, which is the outcome measure for the spatial sensitivity analysis.

TL;DR: Exp 1: control vs 30” K+ (P<0.0001); control vs. 2’ K+ ($1,000,000; $1,500,000) (P.<0.0005; £1,200,000).