Jack M. Guralnik

TL;DR: Evidence is presented that performance measures can validly characterize older persons across a broad spectrum of lower extremity function and that performance and self-report measures may complement each other in providing useful information about functional status.

TL;DR: Among nondisabled older persons living in the community, objective measures of lower-extremity function were highly predictive of subsequent disability.

TL;DR: Performance tests of lower extremity function accurately predict disability across diverse populations and Equations derived from models using both the summary score and the gait speed alone allow for the estimation of risk of disability in community-dwelling populations and provide valuable information for estimating sample size for clinical trials of disability prevention.

TL;DR: Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.

TL;DR: Optimal cutoff values that can be used in the clinical practice to identify older persons with poor mobility were developed and lay the basis for a cost-effective, clinical marker of sarcopenia based on a measure of isometric handgrip strength.