J
Jacky Wing Yip Lam
Researcher at Hong Kong University of Science and Technology
Publications - 698
Citations - 55632
Jacky Wing Yip Lam is an academic researcher from Hong Kong University of Science and Technology. The author has contributed to research in topics: Polymer & Polymerization. The author has an hindex of 106, co-authored 619 publications receiving 44048 citations. Previous affiliations of Jacky Wing Yip Lam include University of Hong Kong & Shenzhen University.
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Highly efficient singlet oxygen generation, two-photon photodynamic therapy and melanoma ablation by rationally designed mitochondria-specific near-infrared AIEgens.
Zheng Zheng,Haixiang Liu,Shaodong Zhai,Haoke Zhang,Guo-Gang Shan,Ryan T. K. Kwok,Chao Ma,Herman H. Y. Sung,Ian D. Williams,Jacky Wing Yip Lam,Kam Sing Wong,Xianglong Hu,Ben Zhong Tang,Ben Zhong Tang +13 more
TL;DR: Upon ultralow-power light irradiation at 4.2 mW cm−2, in situ mitochondrial photodynamic activation to specifically damage cancer cells and efficient in vivo melanoma ablation are demonstrated, suggesting superior potency of the AIE PS in imaging-guided PDT with minimal side effects, which is promising for future precision medicine.
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Non-aromatic annulene-based aggregation-induced emission system via aromaticity reversal process.
Zheng Zhao,Xiaoyan Zheng,Lili Du,Lili Du,Yu Xiong,Wei He,Xiuxiu Gao,Chunli Li,Yingjie Liu,Bin Xu,Jing Zhang,Fengyan Song,Ying Yu,Xueqian Zhao,Yuanjing Cai,Xuewen He,Ryan T. K. Kwok,Jacky Wing Yip Lam,Xuhui Huang,David Lee Phillips,Hua Wang,Ben Zhong Tang,Ben Zhong Tang +22 more
TL;DR: A further mechanism for AIE is reported, through aromaticity reversal from the ground state to the excited state, in the non-aromatic annulene derivative of cyclooctatetrathiophene, which is demonstrated as a reliable strategy to develop vibrational AIE systems.
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Syntheses, hydrogen-bonding interactions, tunable chain helicities, and cooperative supramolecular associations and dissociations of poly(phenylacetylene)s bearing L-valine pendants: Toward the development of proteomimetic polyenes
TL;DR: In this paper, the 4-Ethynylbenzoyl-l-valine methyl ester (1e), an acetylene−valine adduct, is polymerized by organorhodium catalysts to the corresponding polyester (P1e) of high molecular weights (Mw up to 371,000) and high stereoregularities (Z content up to 100%).
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Restriction of Access to the Dark State: A New Mechanistic Model for Heteroatom-Containing AIE Systems.
TL;DR: This work takes more than one excited state into account and specifies a mechanism -"restriction of access to dark state (RADS)" - to explain the AIE effect of heteroatom-containing molecules and RADS is found to be powerful in elucidating the photophysics of AIE materials with excited states favouring non-radiative decay.
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Aggregation-Induced Nonlinear Optical Effects of AIEgen Nanocrystals for Ultradeep In Vivo Bioimaging
Zheng Zheng,Dongyu Li,Zhiyang Liu,Hui-Qing Peng,Herman H. Y. Sung,Ryan T. K. Kwok,Ian D. Williams,Jacky Wing Yip Lam,Jun Qian,Ben Zhong Tang,Ben Zhong Tang +10 more
TL;DR: A simple method for preparing organic nanocrystals based on an aggregation‐induced emission (AIE) luminogen (DCCN) with bright near‐infrared emission is successfully demonstrated and is expected to inspire new insights into the development of advanced AIE materials with multiple nonlinearity, in particular THG, for multimodal nonlinear optical microscopy.