S
Shin Jung
Researcher at Chonnam National University
Publications - 239
Citations - 7405
Shin Jung is an academic researcher from Chonnam National University. The author has contributed to research in topics: Glioma & Meningioma. The author has an hindex of 38, co-authored 228 publications receiving 6197 citations. Previous affiliations of Shin Jung include University of Toronto & Paracelsus Private Medical University of Salzburg.
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Journal ArticleDOI
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Paul A. Northcott,Paul A. Northcott,David Shih,John Peacock,Livia Garzia,A. Sorana Morrissy,Thomas Zichner,Adrian M. Stütz,Andrey Korshunov,Jüri Reimand,Steven E. Schumacher,Rameen Beroukhim,Rameen Beroukhim,David W. Ellison,Christian R. Marshall,Anath C. Lionel,Stephen C. Mack,Adrian M. Dubuc,Yuan Yao,Vijay Ramaswamy,Betty Luu,Adi Rolider,Florence M.G. Cavalli,Xin Wang,Marc Remke,Xiaochong Wu,Readman Chiu,Andy Chu,Eric Chuah,Richard Corbett,Gemma Hoad,Shaun D. Jackman,Yisu Li,Allan Lo,Karen Mungall,Ka Ming Nip,Jenny Q. Qian,Anthony Raymond,Nina Thiessen,Richard Varhol,Inanc Birol,Richard A. Moore,Andrew J. Mungall,Robert A. Holt,Daisuke Kawauchi,Martine F. Roussel,Marcel Kool,David T.W. Jones,Hendrick Witt,Africa Fernandez-L,Anna Kenney,Robert J. Wechsler-Reya,Peter B. Dirks,Tzvi Aviv,Wiesława Grajkowska,Marta Perek-Polnik,Christine Haberler,Olivier Delattre,Stéphanie Reynaud,François Doz,Sarah S. Pernet-Fattet,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Wolfram Scheurlen,Charles G. Eberhart,Michelle Fèvre-Montange,Anne Jouvet,Ian F. Pollack,Xing Fan,Karin M. Muraszko,G. Yancey Gillespie,Concezio Di Rocco,Luca Massimi,Erna M.C. Michiels,Nanne K. Kloosterhof,Pim J. French,Johan M. Kros,James M. Olson,Richard G. Ellenbogen,Karel Zitterbart,Leos Kren,Reid C. Thompson,Michael K. Cooper,Boleslaw Lach,Boleslaw Lach,Roger E. McLendon,Darell D. Bigner,Adam M. Fontebasso,Steffen Albrecht,Steffen Albrecht,Nada Jabado,Janet C. Lindsey,Simon Bailey,Nalin Gupta,William A. Weiss,László Bognár,Almos Klekner,Timothy E. Van Meter,Toshihiro Kumabe,Teiji Tominaga,Samer K. Elbabaa,Jeffrey R. Leonard,Joshua B. Rubin,Linda M. Liau,Erwin G. Van Meir,Maryam Fouladi,Hideo Nakamura,Giuseppe Cinalli,Miklós Garami,Peter Hauser,Ali G. Saad,Achille Iolascon,Shin Jung,Carlos Gilberto Carlotti,Rajeev Vibhakar,Young Shin Ra,Shenandoah Robinson,Massimo Zollo,Claudia C. Faria,Jennifer A. Chan,Michael J. Levy,Poul H. Sorensen,Matthew Meyerson,Scott L. Pomeroy,Yoon Jae Cho,Gary D. Bader,Uri Tabori,Cynthia Hawkins,Eric Bouffet,Stephen W. Scherer,James T. Rutka,David Malkin,Steven C. Clifford,Steven J.M. Jones,Jan O. Korbel,Stefan M. Pfister,Stefan M. Pfister,Marco A. Marra,Michael D. Taylor +139 more
TL;DR: Somatic copy number aberrations (SCNAs) in 1,087 unique medulloblastomas are reported, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Groups 4, which suggest future avenues for rational, targeted therapy.
Journal ArticleDOI
Intertumoral Heterogeneity within Medulloblastoma Subgroups
Florence M.G. Cavalli,Marc Remke,Marc Remke,Marc Remke,Ladislav Rampášek,John Peacock,David Shih,Betty Luu,Livia Garzia,Jonathon Torchia,Carolina Nor,A. Sorana Morrissy,Sameer Agnihotri,Yuan Yao Thompson,Claudia M. Kuzan-Fischer,Hamza Farooq,Keren Isaev,Keren Isaev,Craig Daniels,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Ji Yeoun Lee,Wiesława Grajkowska,Marta Perek-Polnik,Alexandre Vasiljevic,Cécile Faure-Conter,Anne Jouvet,Caterina Giannini,Amulya A. Nageswara Rao,Kay Ka Wai Li,Ho Keung Ng,Charles G. Eberhart,Ian F. Pollack,Ronald L. Hamilton,G. Yancey Gillespie,James M. Olson,James M. Olson,Sarah Leary,William A. Weiss,Boleslaw Lach,Boleslaw Lach,Lola B. Chambless,Reid C. Thompson,Michael K. Cooper,Rajeev Vibhakar,Peter Hauser,Marie Lise C. van Veelen,Johan M. Kros,Pim J. French,Young Shin Ra,Toshihiro Kumabe,Enrique López-Aguilar,Karel Zitterbart,Jaroslav Sterba,Gaetano Finocchiaro,Maura Massimino,Erwin G. Van Meir,Satoru Osuka,Tomoko Shofuda,Almos Klekner,Massimo Zollo,Jeffrey R. Leonard,Joshua B. Rubin,Nada Jabado,Steffen Albrecht,Steffen Albrecht,Jaume Mora,Timothy E. Van Meter,Shin Jung,Andrew S. Moore,Andrew R. Hallahan,Jennifer A. Chan,Daniela Pretti da Cunha Tirapelli,Carlos Gilberto Carlotti,Maryam Fouladi,José Pimentel,Claudia C. Faria,Ali G. Saad,Luca Massimi,Linda M. Liau,Helen Wheeler,Hideo Nakamura,Samer K. Elbabaa,Mario Perezpeña-Diazconti,Fernando Chico Ponce de León,Shenandoah Robinson,Michal Zapotocky,Alvaro Lassaletta,Annie Huang,Cynthia Hawkins,Uri Tabori,Eric Bouffet,Ute Bartels,Peter B. Dirks,James T. Rutka,Gary D. Bader,Jüri Reimand,Jüri Reimand,Anna Goldenberg,Vijay Ramaswamy,Michael D. Taylor +101 more
TL;DR: Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes.
Journal ArticleDOI
Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma
Nataliya Zhukova,Vijay Ramaswamy,Marc Remke,Elke Pfaff,David Shih,Dianna Martin,Pedro Castelo-Branco,Berivan Baskin,Peter N. Ray,Eric Bouffet,André O. von Bueren,André O. von Bueren,David T.W. Jones,Paul A. Northcott,M Kool,Dominik Sturm,Trevor J. Pugh,Scott L. Pomeroy,Yoon Jae Cho,Torsten Pietsch,Marco Gessi,Stefan Rutkowski,László Bognár,Almos Klekner,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Charles G. Eberhart,Michelle Fèvre-Montange,Maryam Fouladi,Pim J. French,Max Kros,Wiesława Grajkowska,Nalin Gupta,William A. Weiss,Peter Hauser,Nada Jabado,Anne Jouvet,Shin Jung,Toshihiro Kumabe,Boleslaw Lach,Jeffrey R. Leonard,Joshua B. Rubin,Linda M. Liau,Luca Massimi,Ian F. Pollack,Young Shin Ra,Erwin G. Van Meir,Karel Zitterbart,Ulrich Schüller,Rebecca M Hill,Janet C. Lindsey,Edward C. Schwalbe,Simon Bailey,David W. Ellison,Cynthia Hawkins,David Malkin,Steven C. Clifford,Andrey Korshunov,Stefan M. Pfister,Michael D. Taylor,Uri Tabori +61 more
TL;DR: Subgroup-specific analysis reconciles prior conflicting publications and confirms that TP53 mutations are enriched among SHH medulloblastomas, in which they portend poor outcome and account for a large proportion of treatment failures in these patients.
Journal ArticleDOI
Cytogenetic Prognostication Within Medulloblastoma Subgroups
David Shih,Paul A. Northcott,Marc Remke,Andrey Korshunov,Vijay Ramaswamy,Marcel Kool,Betty Luu,Yuan Yao,Xin Wang,Adrian M. Dubuc,Livia Garzia,John Peacock,Stephen C. Mack,Xiaochong Wu,Adi Rolider,A. Sorana Morrissy,Florence M.G. Cavalli,David T.W. Jones,Karel Zitterbart,Claudia C. Faria,Claudia C. Faria,Ulrich Schüller,Leos Kren,Toshihiro Kumabe,Teiji Tominaga,Young Shin Ra,Miklós Garami,Peter Hauser,Jennifer A. Chan,Shenandoah Robinson,László Bognár,Almos Klekner,Ali G. Saad,Linda M. Liau,Steffen Albrecht,Adam M. Fontebasso,Giuseppe Cinalli,Pasqualino De Antonellis,Massimo Zollo,Michael K. Cooper,Reid C. Thompson,Simon Bailey,Janet C. Lindsey,Concezio Di Rocco,Luca Massimi,Erna M.C. Michiels,Stephen W. Scherer,Joanna J. Phillips,Nalin Gupta,Xing Fan,Karin M. Muraszko,Rajeev Vibhakar,Charles G. Eberhart,Maryam Fouladi,Boleslaw Lach,Shin Jung,Robert J. Wechsler-Reya,Michelle Fèvre-Montange,Anne Jouvet,Nada Jabado,Ian F. Pollack,William A. Weiss,Ji Yeoun Lee,Byung Kyu Cho,Seung-Ki Kim,Kyu-Chang Wang,Jeffrey R. Leonard,Joshua B. Rubin,Carmen de Torres,Cinzia Lavarino,Jaume Mora,Yoon Jae Cho,Uri Tabori,James M. Olson,Amar Gajjar,Roger J. Packer,Stefan Rutkowski,Scott L. Pomeroy,Pim J. French,Nanne K. Kloosterhof,Johan M. Kros,Erwin G. Van Meir,Steven C. Clifford,Franck Bourdeaut,Olivier Delattre,François Doz,François Doz,Cynthia Hawkins,David Malkin,Wiesława Grajkowska,Marta Perek-Polnik,Eric Bouffet,James T. Rutka,Stefan M. Pfister,Stefan M. Pfister,Michael D. Taylor +95 more
TL;DR: A small panel of cytogenetic biomarkers is identified that reliably identifies very high-risk and very low-risk groups of patients, making it an excellent tool for selecting patients for therapy intensification and therapy de-escalation in future clinical trials.
Journal ArticleDOI
Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis
Eric M. Thompson,Eric M. Thompson,Thomas Hielscher,Eric Bouffet,Marc Remke,Betty Luu,Sridharan Gururangan,Roger E. McLendon,Darell D. Bigner,Eric S. Lipp,Sébastien Perreault,Yoon Jae Cho,Gerald A. Grant,Gerald A. Grant,Seung-Ki Kim,Ji Yeoun Lee,Amulya A. Nageswara Rao,Caterina Giannini,Kay Ka Wai Li,Ho Keung Ng,Yu Yao,Toshihiro Kumabe,Teiji Tominaga,Wiesława Grajkowska,Marta Perek-Polnik,David C.Y. Low,Wan Tew Seow,Kenneth Tou En Chang,Jaume Mora,Ian F. Pollack,Ronald L. Hamilton,Sarah Leary,Andrew S. Moore,Andrew S. Moore,Wendy J. Ingram,Andrew R. Hallahan,Andrew R. Hallahan,Anne Jouvet,Michelle Fèvre-Montange,Alexandre Vasiljevic,Cécile Faure-Conter,Tomoko Shofuda,Naoki Kagawa,Naoya Hashimoto,Nada Jabado,Alexander G. Weil,Tenzin Gayden,Takafumi Wataya,Tarek Shalaby,Michael A. Grotzer,Karel Zitterbart,Jaroslav Sterba,Leos Kren,Tibor Hortobágyi,Almos Klekner,Bognár László,Tímea Pócza,Peter Hauser,Ulrich Schüller,Shin Jung,Woo Youl Jang,Pim J. French,Johan M. Kros,Marie Lise C. van Veelen,Luca Massimi,Jeffrey R. Leonard,Joshua B. Rubin,Rajeev Vibhakar,Lola B. Chambless,Michael K. Cooper,Reid C. Thompson,Claudia C. Faria,Alice Carvalho,Sofia Nunes,José Pimentel,Xing Fan,Karin M. Muraszko,Enrique López-Aguilar,David Lyden,Livia Garzia,David Shih,Noriyuki Kijima,Christian Schneider,Jennifer Adamski,Paul A. Northcott,Marcel Kool,David T.W. Jones,Jennifer A. Chan,Ana Nikolic,Maria Luisa Garrè,Erwin G. Van Meir,Satoru Osuka,Jeffrey J. Olson,Arman Jahangiri,Brandyn A. Castro,Nalin Gupta,William A. Weiss,Iska Moxon-Emre,Donald J. Mabbott,Alvaro Lassaletta,Cynthia Hawkins,Uri Tabori,James M. Drake,Abhaya V. Kulkarni,Peter B. Dirks,James T. Rutka,Andrey Korshunov,Stefan M. Pfister,Stefan M. Pfister,Roger J. Packer,Vijay Ramaswamy,Michael D. Taylor +111 more
TL;DR: A re-evaluation of the long-term implications of intensified craniospinal irradiation in children with small residual portions of medulloblastoma is suggested as the marked benefit of EOR in the overall cohort was greatly attenuated after including molecular subgroup in the multivariable analysis.