Lung pathology of fatal severe acute respiratory syndrome
John M. Nicholls,Leo L.M. Poon,Kam Cheong Lee,Wai F. Ng,Sik T. Lai,Chung Y. Leung,Chung M. Chu,Pak K. Hui,K.L. Mak,Wilina Lim,Kin W. Yan,Kwok H. Chan,Ngai C. Tsang,Yi Guan,Kwok-Yung Yuen,J. S. Peiris +15 more
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TLDR
The presence of haemophagocytosis supports the contention that cytokine dysregulation may account, at least partly, for the severity of the clinical disease.About:
This article is published in The Lancet.The article was published on 2003-05-24 and is currently open access. It has received 1011 citations till now. The article focuses on the topics: Diffuse alveolar damage & Severe acute respiratory syndrome.read more
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Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China
Chaomin Wu,Xiaoyan Chen,Yanping Cai,Jia’an Xia,Xing Zhou,Sha Xu,Han-Ping Huang,Li Zhang,Xia Zhou,Chunling Du,Yuye Zhang,Juan Song,Sijiao Wang,Yencheng Chao,Zeyong Yang,Jie Xu,Xin Zhou,Dechang Chen,Weining Xiong,Lei Xu,Feng Zhou,Jinjun Jiang,Chunxue Bai,Zheng Junhua,Yuanlin Song +24 more
TL;DR: Although high fever was associated with the development of ARDS, it was also associated with better outcomes among patients with ARDS and treatment with methylprednisolone may be beneficial for patients who develop ARDS.
Journal ArticleDOI
Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis
TL;DR: ACE2 is abundantly present in humans in the epithelia of the lung and small intestine, which might provide possible routes of entry for the SARS‐CoV.
Journal ArticleDOI
Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.
Maximilian Ackermann,Stijn E. Verleden,Mark Kuehnel,Axel Haverich,Tobias Welte,Florian Laenger,Arno Vanstapel,Christopher Werlein,Helge Stark,Alexandar Tzankov,William W. Li,Vincent W. Li,Steven J. Mentzer,Danny Jonigk +13 more
TL;DR: In this small series, vascular angiogenesis distinguished the pulmonary pathobiology of Covid-19 from that of equally severe influenza virus infection.
Journal ArticleDOI
The severe acute respiratory syndrome.
TL;DR: The concerted and coordinated response that contained SARS is a triumph for global public health and provides a new paradigm for the detection and control of future emerging infectious disease threats.
Journal ArticleDOI
Extrapulmonary manifestations of COVID-19.
Aakriti Gupta,Aakriti Gupta,Mahesh V. Madhavan,Kartik Sehgal,Kartik Sehgal,Nandini Nair,Shiwani Mahajan,Tejasav S. Sehrawat,Behnood Bikdeli,Behnood Bikdeli,Neha Ahluwalia,John C. Ausiello,Elaine Wan,Daniel E. Freedberg,Ajay J. Kirtane,Sahil A. Parikh,Mathew S. Maurer,Anna S. Nordvig,Domenico Accili,Joan M. Bathon,Sumit Mohan,Kenneth A. Bauer,Kenneth A. Bauer,Martin B. Leon,Harlan M. Krumholz,Nir Uriel,Mandeep R. Mehra,Mitchell S.V. Elkind,Mitchell S.V. Elkind,Gregg W. Stone,Allan Schwartz,David D. Ho,John P. Bilezikian,Donald W. Landry +33 more
TL;DR: The extrapulmonary organ-specific pathophysiology, presentations and management considerations for patients with COVID-19 are reviewed to aid clinicians and scientists in recognizing and monitoring the spectrum of manifestations, and in developing research priorities and therapeutic strategies for all organ systems involved.
References
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A novel coronavirus associated with severe acute respiratory syndrome.
Thomas G. Ksiazek,Dean D. Erdman,Cynthia S. Goldsmith,Zaki,Teresa C. T. Peret,Shannon L. Emery,Suxiang Tong,Urbani C,James A. Comer,Wilina Lim,Pierre E. Rollin,Scott F. Dowell,Ai Ee Ling,Charles D. Humphrey,Wun-Ju Shieh,Jeannette Guarner,Christopher D. Paddock,Paul A. Rota,Barry S. Fields,Joseph L. DeRisi,Jyh-Yuan Yang,Nancy J. Cox,James M. Hughes,James W. LeDuc,William J. Bellini,Larry J. Anderson +25 more
TL;DR: A novel coronavirus is associated with this outbreak of severe acute respiratory syndrome, and the evidence indicates that this virus has an etiologic role in SARS.
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Coronavirus as a possible cause of severe acute respiratory syndrome
Jsm Peiris,Sik To Lai,Llm Poon,Yi Guan,Lyc Yam,Wilina Lim,John M. Nicholls,Wks Yee,WW Yan,MT Cheung,V. C. C. Cheng,KH Chan,Dnc Tsang,R Yung,Ting Kin Ng,KY Yuen +15 more
TL;DR: Serological and molecular tests specific for the virus permitted a definitive laboratory diagnosis to be made and allowed further investigation to define whether other cofactors play a part in disease progression.
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A Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong
Nelson Lee,David S.C. Hui,Alan Wu,Paul K.S. Chan,Peter Cameron,Gavin M. Joynt,Anil T. Ahuja,Man Yee Yung,Chi-Bon Leung,Ka Fai To,Siu F. Lui,Cheuk-Chun Szeto,S.C.Sydney Chung,Joseph J.Y. Sung +13 more
TL;DR: SARS is a serious respiratory illness that led to significant morbidity and mortality in this cohort of 138 cases of suspected SARS during a hospital outbreak in Hong Kong.
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Identification of Severe Acute Respiratory Syndrome in Canada
Susan M. Poutanen,Susan M. Poutanen,Donald E. Low,Bonnie Henry,Sandy Finkelstein,David Rose,Karen Green,Raymond Tellier,Raymond Tellier,Ryan Draker,Dena Adachi,Melissa Ayers,Adrienne K. Chan,Danuta M. Skowronski,Irving E. Salit,Andrew E. Simor,Arthur S. Slutsky,Patrick Doyle,Mel Krajden,Martin Petric,Robert C. Brunham,Allison McGeer +21 more
TL;DR: SARS appears to be of viral origin, with patterns suggesting droplet or contact transmission, and the role of human metapneumovirus, a novel coronavirus, or both requires further investigation.
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Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus.
Kwok-Yung Yuen,Paul K.S. Chan,Malik Peiris,D. N. C. Tsang,Tak-Lun Que,Kennedy F. Shortridge,P. T. Cheung,W. K. To,E. T. F. Ho,R. Sung,A. F. B. Cheng +10 more
TL;DR: Avian Influenza A H5N1 virus causes human influenza-like illness with a high rate of complications in adults admitted to hospital, and rapid H5-subtype-specific laboratory diagnosis can be made by RT-PCR applied directly to clinical specimens.
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