J
Juan A. Botía
Researcher at University of Murcia
Publications - 182
Citations - 4518
Juan A. Botía is an academic researcher from University of Murcia. The author has contributed to research in topics: Gene & Context (language use). The author has an hindex of 25, co-authored 162 publications receiving 3017 citations. Previous affiliations of Juan A. Botía include Middlesex University & King's College London.
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Journal ArticleDOI
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Mike A. Nalls,Cornelis Blauwendraat,Costanza L. Vallerga,Karl Heilbron,Sara Bandres-Ciga,Diana Chang,Manuela Tan,Demis A. Kia,Alastair J. Noyce,Alastair J. Noyce,Angli Xue,Jose Bras,Jose Bras,Emily Young,Rainer von Coelln,Javier Simón-Sánchez,Javier Simón-Sánchez,Claudia Schulte,Claudia Schulte,Manu Sharma,Lynne Krohn,Lynne Krohn,Lasse Pihlstrøm,Ari Siitonen,Ari Siitonen,Hirotaka Iwaki,Hirotaka Iwaki,Leonard H,Faraz Faghri,Faraz Faghri,J. Raphael Gibbs,Dena G. Hernandez,Sonja W. Scholz,Sonja W. Scholz,Juan A. Botía,Juan A. Botía,Maria Martinez,Maria Martinez,Jean-Christophe Corvol,Suzanne Lesage,Joseph Jankovic,Lisa M. Shulman,Margaret Sutherland,Pentti J. Tienari,Kari Majamaa,Kari Majamaa,Mathias Toft,Mathias Toft,Ole A. Andreassen,Ole A. Andreassen,Tushar Bangale,Alexis Brice,Jian Yang,Ziv Gan-Or,Ziv Gan-Or,Thomas Gasser,Thomas Gasser,Peter Heutink,Peter Heutink,Joshua M. Shulman,Nicholas W. Wood,David A. Hinds,John Hardy,Huw R. Morris,Jacob Gratten,Peter M. Visscher,Robert R. Graham,Andrew B. Singleton,Astrid Adarmes-Gómez,Miquel Aguilar,Akbota Aitkulova,Vadim Akhmetzhanov,Roy N. Alcalay,Ignacio Alvarez,Victoria Alvarez,Francisco J. Barrero,Jesús Alberto Bergareche Yarza,Inmaculada Bernal-Bernal,Kimberley Billingsley,Marta Blazquez,Marta Bonilla-Toribio,María Teresa Boungiorno,Kathrin Brockmann,Vivien J. Bubb,Dolores Buiza-Rueda,Ana Cámara,Fátima Carrillo,Mario Carrión-Claro,Debora Cerdan,Viorica Chelban,Jordi Clarimón,Carl E Clarke,Yaroslau Compta,Mark R. Cookson,David Craig,Fabrice Danjou,Monica Diez-Fairen,Oriol Dols-Icardo,Jacinto Duarte,Raquel Duran,Francisco Escamilla-Sevilla,Valentina Escott-Price,Mario Ezquerra,Cici Feliz,Manel Fernández,Rubén Fernández-Santiago,Steven Finkbeiner,Thomas Foltynie,Ciara Garcia,Pedro J. Garcia-Ruiz,Maria Jose Gomez Heredia,Pilar Gómez-Garre,Manuel Menéndez González,Isabel González-Aramburu,Sebastian Guelfi,Rita Guerreiro,John Hardy,Sharon Hassin-Baer,Janet Hoenicka,Peter Holmans,Henry Houlden,Jon Infante,Silvia Jesús,Adriano Jimenez-Escrig,Gulnaz Kaishybayeva,Rauan Kaiyrzhanov,Altynay Karimova,Kerri J. Kinghorn,Sulev Kõks,Jaime Kulisevsky,Miguel A. Labrador-Espinosa,Hampton L. Leonard,Patrick A. Lewis,Jose Lopez-Sendon,Ruth C. Lovering,Steven J. Lubbe,Codrin Lungu,Daniel Macias,Claudia Manzoni,Juan Marín,Johan Marinus,María José Martí,Irene Martínez Torres,Juan Carlos Martínez-Castrillo,Marina Mata,Niccolo E. Mencacci,Carlota Méndez-del-Barrio,Ben Middlehurst,Adolfo Mínguez,Pablo Mir,Kin Y. Mok,Esteban Muñoz,Derek P. Narendra,Oluwadamilola O. Ojo,Njideka U Okubadejo,Ana Gorostidi Pagola,Pau Pastor,Francisco Perez Errazquin,Teresa Periñán-Tocino,Helene Plun-Favreau,John P. Quinn,Lea R'Bibo,Xylena Reed,Elisabet Mondragon Rezola,Mie Rizig,Patrizia Rizzu,Laurie Robak,Antonio Sanchez Rodriguez,Guy A. Rouleau,Javier Ruiz-Martínez,Clara Ruz,Mina Ryten,Dinara Sadykova,Sebastian R Schreglmann,Chingiz Shashkin,María Sierra,Esther Suarez-Sanmartin,Pille Taba,Cesar Tabernero,Manuela X Tan,Juan Pablo Tartari,Cristina Tejera-Parrado,Eduard Tolosa,Daniah Trabzuni,Francesc Valldeoriola,Jacobus J. van Hilten,Kendall Van Keuren-Jensen,Laura Vargas-González,Lydia Vela,Francisco Vives,Nigel Williams,Nazira Zharkinbekova,Zharkyn Zharmukhanov,Elena Zholdybayeva,Alexander Zimprich,Pauli Ylikotila,Stephen G. Reich,Joseph M. Savitt,Michelle Agee,Babak Alipanahi,Adam Auton,Robert K. Bell,Katarzyna Bryc,Sarah L. Elson,Pierre Fontanillas,Nicholas A. Furlotte,Karen E. Huber,Barry W. Hicks,Ethan M. Jewett,Yunxuan Jiang,Aaron Kleinman,Keng-Han Lin,Nadia K. Litterman,Jennifer C. McCreight,Matthew H. McIntyre,Kimberly F. McManus,Joanna L. Mountain,Elizabeth S. Noblin,Carrie A.M. Northover,Steven J. Pitts,G. David Poznik,J. Fah Sathirapongsasuti,Janie F. Shelton,Suyash Shringarpure,Chao Tian,Joyce Y. Tung,Vladimir Vacic,Xin Wang,Catherine H. Wilson,Tim J. Anderson,Steven R. Bentley,John C. Dalrymple-Alford,Javed Fowdar,Glenda M. Halliday,Anjali K. Henders,Ian B. Hickie,Irfahan Kassam,Martin A. Kennedy,John B.J. Kwok,Simon J.G. Lewis,George D. Mellick,Grant W. Montgomery,John F. Pearson,Toni L. Pitcher,Julia Sidorenko,Peter A. Silburn,Leanne Wallace,Naomi R. Wray,Futao Zhang +248 more
TL;DR: These data provide the most comprehensive survey of genetic risk within Parkinson's disease to date, providing a biological context for these risk factors, and showing that a considerable genetic component of this disease remains unidentified.
Journal ArticleDOI
Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study.
Christopher D. Whelan,Christopher D. Whelan,Andre Altmann,Juan A. Botía,Neda Jahanshad,Derrek P. Hibar,Julie Absil,Saud Alhusaini,Saud Alhusaini,Marina K. M. Alvim,Pia Auvinen,Emanuele Bartolini,Felipe P. G. Bergo,Tauana Bernardes,Karen Blackmon,Karen Blackmon,Barbara Braga,Maria Eugenia Caligiuri,Anna Calvo,Sarah J. A. Carr,Jian Chen,Shuai Chen,Andrea Cherubini,Philippe David,Martin Domin,Sonya Foley,Wendy Franca,Gerrit Haaker,Dmitry Isaev,Simon S. Keller,Raviteja Kotikalapudi,Magdalena A. Kowalczyk,Ruben Kuzniecky,Soenke Langner,Matteo Lenge,Kelly M. Leyden,Min Liu,Richard Q. Loi,Pascal Martin,Mario Mascalchi,Mario Mascalchi,Marcia Elisabete Morita,Jose C. Pariente,Raúl Rodríguez-Cruces,Christian Rummel,Taavi Saavalainen,Mira Semmelroch,Mariasavina Severino,Rhys H. Thomas,Rhys H. Thomas,Manuela Tondelli,Domenico Tortora,Anna Elisabetta Vaudano,Lucy Vivash,Lucy Vivash,Felix von Podewils,Jan Wagner,Jan Wagner,Bernd Weber,Yi Yao,Clarissa L. Yasuda,Guohao Zhang,Núria Bargalló,Benjamin Bender,Neda Bernasconi,Andrea Bernasconi,Boris C. Bernhardt,Ingmar Blümcke,Chad Carlson,Chad Carlson,Gianpiero L. Cavalleri,Fernando Cendes,Luis Concha,Norman Delanty,Norman Delanty,Chantal Depondt,Orrin Devinsky,Colin P. Doherty,Niels K. Focke,Antonio Gambardella,Renzo Guerrini,Khalid Hamandi,Khalid Hamandi,Graeme D. Jackson,Graeme D. Jackson,Reetta Kälviäinen,Peter Kochunov,Patrick Kwan,Angelo Labate,Carrie R. McDonald,Stefano Meletti,Terence J. O'Brien,Terence J. O'Brien,Sebastien Ourselin,Mark P. Richardson,Mark P. Richardson,Pasquale Striano,Thomas Thesen,Thomas Thesen,Roland Wiest,Junsong Zhang,Annamaria Vezzani,Mina Ryten,Mina Ryten,Paul M. Thompson,Sanjay M. Sisodiya +105 more
TL;DR: In the largest neuroimaging study to date, Whelan and colleagues report robust structural alterations across and within epilepsy syndromes, including shared volume loss in the thalamus, and widespread cortical thickness differences.
Journal ArticleDOI
An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks
Juan A. Botía,Juan A. Botía,Jana Vandrovcova,Paola Forabosco,Sebastian Guelfi,Karishma D’Sa,Karishma D’Sa,John R Hardy,Cathryn M. Lewis,Mina Ryten,Mina Ryten,Michael E. Weale +11 more
TL;DR: The results obtained from investigations indicate that the k-means method, applied as an adjunct to standard WGCNA, results in better network partitions, which enable more fruitful downstream analyses, as gene modules are more biologically meaningful.
Journal ArticleDOI
Ambient Assisted Living system for in-home monitoring of healthy independent elders
TL;DR: One of the main contributions of the proposed work is an exhaustive evaluation methodology that is integrated in the development process that is related with the capability of the system to adapt its behavior to that of the monitored elder.
Posted ContentDOI
Expanding Parkinson’s disease genetics: novel risk loci, genomic context, causal insights and heritable risk
Mike A. Nalls,Cornelis Blauwendraat,Costanza L. Vallerga,Karl Heilbron,Sara Bandres-Ciga,Diana Chang,Manuela Tan,Demis A. Kia,Alastair J. Noyce,Alastair J. Noyce,Angli Xue,Jose Bras,Jose Bras,Emily Young,Rainer von Coelln,Javier Simón-Sánchez,Javier Simón-Sánchez,Claudia Schulte,Claudia Schulte,Manu Sharma,Lynne Krohn,Lynne Krohn,Lasse Pihlstrøm,Ari Siitonen,Ari Siitonen,Hirotaka Iwaki,Hampton L. Leonard,Faraz Faghri,J. Raphael Gibbs,Dena G. Hernandez,Sonja W. Scholz,Sonja W. Scholz,Juan A. Botía,Juan A. Botía,Maria Martinez,Jean-Christophe Corvol,Suzanne Lesage,Joseph Jankovic,Lisa M. Shulman,Margaret Sutherland,Pentti J. Tienari,Kari Majamaa,Kari Majamaa,Mathias Toft,Mathias Toft,Ole A. Andreassen,Ole A. Andreassen,Tushar Bangale,Alexis Brice,Jian Yang,Ziv Gan-Or,Ziv Gan-Or,Thomas Gasser,Thomas Gasser,Peter Heutink,Peter Heutink,Joshua M. Shulman,Joshua M. Shulman,N Wood,David A. Hinds,John Hardy,Huw R. Morris,Jacob Gratten,Peter M. Visscher,Robert R. Graham,Andrew B. Singleton +65 more
TL;DR: These data provide the most comprehensive understanding of the genetic architecture of PD to date by revealing many additional PD risk loci, providing a biological context for these risk factors, and demonstrating that a considerable genetic component of this disease remains unidentified.