Pall T. Onundarson

TL;DR: A genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals identifies 75 independent genetic loci associated with one or more red blood cell phenotypes at P < 10−8, which together explain 4–9% of the phenotypic variance per trait.

TL;DR: In this article, the authors carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals and identified 75 independent genetic loci associated with one or more red blood cell phenotypes at P < 10−8, which together explain 4-9% of the phenotypic variance per trait.

TL;DR: It was found that rs7025486[A], located within DAB2IP, which encodes an inhibitor of cell growth and survival, is associated with early onset myocardial infarction, but not with intracranial aneurysm or ischemic stroke.

TL;DR: LPA sequence variants were associated with atherosclerotic burden, but not with primarily thrombotic phenotypes, and CAD cases carrying LPA risk variants had increased susceptibility to atherosclerosis manifestations outside of the coronary tree.

TL;DR: Heterozygotes have about 40% lower total IL33 mRNA expression than non-carriers and allele-specific analysis based on RNA sequencing and phased genotypes shows that only 20% of the total expression is from the mutated chromosome.