T
Tatyana Shekhtman
Researcher at University of California, San Diego
Publications - 46
Citations - 1671
Tatyana Shekhtman is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Bipolar disorder & Lithium (medication). The author has an hindex of 15, co-authored 37 publications receiving 1306 citations. Previous affiliations of Tatyana Shekhtman include Mayo Clinic & Veterans Health Administration.
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Journal ArticleDOI
Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study
Liping Hou,Urs Heilbronner,Urs Heilbronner,Franziska Degenhardt,Mazda Adli,Kazufumi Akiyama,Nirmala Akula,Raffaella Ardau,Bárbara Arias,Lena Backlund,Claudio E. M. Banzato,Antoni Benabarre,Susanne Bengesser,Abesh Kumar Bhattacharjee,Joanna M. Biernacka,Armin Birner,Clara Brichant-Petitjean,Elise T. Bui,Pablo Cervantes,Guo-Bo Chen,Hsi-Chung Chen,Caterina Chillotti,Sven Cichon,Sven Cichon,Scott R. Clark,Francesc Colom,David A. Cousins,Cristiana Cruceanu,Piotr M. Czerski,Clarissa de Rosalmeida Dantas,Alexandre Dayer,Bruno Etain,Peter Falkai,Andreas J. Forstner,Louise Frisén,Janice M. Fullerton,Janice M. Fullerton,Sébastien Gard,Julie Garnham,Fernando S. Goes,Paul Grof,Oliver Gruber,Ryota Hashimoto,Joanna Hauser,Stefan Herms,Stefan Herms,Per Hoffmann,Per Hoffmann,Andrea Hofmann,Stéphane Jamain,Esther Jiménez,Jean-Pierre Kahn,Layla Kassem,Sarah Kittel-Schneider,Sebastian Kliwicki,Barbara König,Ichiro Kusumi,N. Lackner,Gonzalo Laje,Mikael Landén,Mikael Landén,Catharina Lavebratt,Marion Leboyer,Susan G. Leckband,Susan G. Leckband,Carlos Jaramillo,Glenda MacQueen,Mirko Manchia,Mirko Manchia,Lina Martinsson,Manuel Mattheisen,Michael McCarthy,Susan L. McElroy,Marina Mitjans,Francis M. Mondimore,Palmiero Monteleone,Palmiero Monteleone,Caroline M. Nievergelt,Markus M. Nöthen,Urban Ösby,Norio Ozaki,Roy H. Perlis,Andrea Pfennig,Daniela Reich-Erkelenz,Guy A. Rouleau,Peter R. Schofield,Peter R. Schofield,K Oliver Schubert,Barbara W. Schweizer,Florian Seemüller,Giovanni Severino,Tatyana Shekhtman,Tatyana Shekhtman,Paul D. Shilling,Kazutaka Shimoda,Christian Simhandl,Claire Slaney,Jordan W. Smoller,Alessio Squassina,Thomas Stamm,Pavla Stopkova,Sarah K. Tighe,Sarah K. Tighe,Alfonso Tortorella,Gustavo Turecki,Julia Volkert,Stephanie H. Witt,Adam Wright,L. Trevor Young,Peter P. Zandi,James B. Potash,J. Raymond DePaulo,Michael Bauer,Eva Z. Reininghaus,Tomas Novak,Jean-Michel Aubry,Mario Maj,Bernhard T. Baune,Philip B. Mitchell,Eduard Vieta,Mark A. Frye,Janusz K. Rybakowski,Po-Hsiu Kuo,Tadafumi Kato,Maria Grigoroiu-Serbanescu,Andreas Reif,Maria Del Zompo,Frank Bellivier,Martin Schalling,Naomi R. Wray,John R. Kelsoe,John R. Kelsoe,Martin Alda,Martin Alda,Marcella Rietschel,Francis J. McMahon,Thomas G. Schulze +136 more
TL;DR: A genome-wide association study of lithium response in 2,563 patients collected by 22 participating sites from the International Consortium on Lithium Genetics (ConLiGen); the largest attempted so far finds a single locus of four linked SNPs on chromosome 21 met genome- wide significance criteria for association with lithium response.
Journal ArticleDOI
Circadian polymorphisms associated with affective disorders
Daniel F. Kripke,Daniel F. Kripke,Caroline M. Nievergelt,Eun-Jeong Joo,Tatyana Shekhtman,John R. Kelsoe +5 more
TL;DR: Findings suggest that perturbations of the circadian gene network at several levels may influence mood disorders, perhaps ultimately through regulation of MAOA and its modulation of dopamine transmission.
Journal ArticleDOI
Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.
Liping Hou,Sarah E. Bergen,Sarah E. Bergen,Nirmala Akula,Jie Song,Christina M. Hultman,Mikael Landén,Mikael Landén,Mazda Adli,Martin Alda,Raffaella Ardau,Bárbara Arias,Jean-Michel Aubry,Lena Backlund,Judith A. Badner,Thomas B. Barrett,Michael Bauer,Bernhard T. Baune,Frank Bellivier,Antonio Benabarre,Susanne Bengesser,Wade H. Berrettini,Abesh Kumar Bhattacharjee,Joanna M. Biernacka,Armin Birner,Cinnamon S. Bloss,Clara Brichant-Petitjean,Elise T. Bui,William Byerley,Pablo Cervantes,Caterina Chillotti,Sven Cichon,Sven Cichon,Francesc Colom,William Coryell,David Craig,Cristiana Cruceanu,Piotr M. Czerski,Tony Davis,Alexandre Dayer,Franziska Degenhardt,Maria Del Zompo,J. Raymond DePaulo,Howard J. Edenberg,Bruno Etain,Peter Falkai,Tatiana Foroud,Andreas J. Forstner,Louise Frisén,Mark A. Frye,Janice M. Fullerton,Janice M. Fullerton,Sébastien Gard,Julie Garnham,Elliot S. Gershon,Fernando S. Goes,Tiffany A. Greenwood,Maria Grigoroiu-Serbanescu,Joanna Hauser,Urs Heilbronner,Urs Heilbronner,Stefanie Heilmann-Heimbach,Stefan Herms,Stefan Herms,Maria Hipolito,Shashi Hitturlingappa,Per Hoffmann,Per Hoffmann,Andrea Hofmann,Stéphane Jamain,Esther Jiménez,Jean-Pierre Kahn,Layla Kassem,John R. Kelsoe,Sarah Kittel-Schneider,Sebastian Kliwicki,Daniel L. Koller,Barbara König,N. Lackner,Gonzalo Laje,Maren Lang,Catharina Lavebratt,William Lawson,Marion Leboyer,Susan G. Leckband,Chunyu Liu,Anna Maaser,Pamela B. Mahon,Wolfgang Maier,Mario Maj,Mirko Manchia,Mirko Manchia,Lina Martinsson,Michael McCarthy,Susan L. McElroy,Melvin G. McInnis,Rebecca McKinney,Philip B. Mitchell,Marina Mitjans,Francis M. Mondimore,Palmiero Monteleone,Palmiero Monteleone,Thomas W. Mühleisen,Caroline M. Nievergelt,Markus M. Nöthen,Tomas Novak,John I. Nurnberger,Evaristus A. Nwulia,Urban Ösby,Andrea Pfennig,James B. Potash,Peter Propping,Andreas Reif,Eva Z. Reininghaus,John P. Rice,Marcella Rietschel,Guy A. Rouleau,Janusz K. Rybakowski,Martin Schalling,William A. Scheftner,Peter R. Schofield,Peter R. Schofield,Nicholas J. Schork,Thomas G. Schulze,Johannes Schumacher,Barbara W. Schweizer,Giovanni Severino,Tatyana Shekhtman,Paul D. Shilling,Christian Simhandl,Claire Slaney,Erin N. Smith,Alessio Squassina,Thomas Stamm,Pavla Stopkova,Fabian Streit,Jana Strohmaier,Szabolcs Szelinger,Sarah K. Tighe,Alfonso Tortorella,Gustavo Turecki,Eduard Vieta,Julia Volkert,Stephanie H. Witt,Adam Wright,Peter P. Zandi,Peng Zhang,Sebastian Zöllner,Francis J. McMahon +148 more
TL;DR: A two-stage meta-analysis of GWAS of bipolar disorder patients and controls revealed genome-wide significant associations at two novel loci, adding to a growing list of common autosomal variants involved in BD and illustrating the power of comparing well-characterized cases to an excess of controls in GWAS.
Journal ArticleDOI
Rare variants in neuronal excitability genes influence risk for bipolar disorder
Seth A. Ament,Szabolcs Szelinger,Gustavo Glusman,Justin Ashworth,Liping Hou,Nirmala Akula,Tatyana Shekhtman,Judith A. Badner,Mary E. Brunkow,Denise E. Mauldin,Anna-Barbara Stittrich,Katherine Rouleau,Sevilla D. Detera-Wadleigh,John I. Nurnberger,Howard J. Edenberg,Elliot S. Gershon,Nicholas J. Schork,Nathan D. Price,Richard Gelinas,Leroy Hood,David Craig,Francis J. McMahon,John R. Kelsoe,Jared C. Roach +23 more
TL;DR: It is concluded that rare variants in neuronal excitability genes contribute to risk for bipolar disorder, both in pedigrees and in the case-control cohort.
Journal ArticleDOI
Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study.
Azmeraw T. Amare,Klaus Oliver Schubert,Klaus Oliver Schubert,Liping Hou,Scott R. Clark,Sergi Papiol,Urs Heilbronner,Urs Heilbronner,Franziska Degenhardt,Fasil Tekola-Ayele,Yi-Hsiang Hsu,Yi-Hsiang Hsu,Tatyana Shekhtman,Mazda Adli,Nirmala Akula,Kazufumi Akiyama,Raffaella Ardau,Bárbara Arias,Jean-Michel Aubry,Lena Backlund,Abesh Kumar Bhattacharjee,Frank Bellivier,Antonio Benabarre,Susanne Bengesser,Joanna M. Biernacka,Armin Birner,Clara Brichant-Petitjean,Pablo Cervantes,Hsi-Chung Chen,Caterina Chillotti,Sven Cichon,Sven Cichon,Cristiana Cruceanu,Piotr M. Czerski,Nina Dalkner,Alexandre Dayer,Maria Del Zompo,J. Raymond DePaulo,Bruno Etain,Peter Falkai,Andreas J. Forstner,Andreas J. Forstner,Andreas J. Forstner,Louise Frisén,Mark A. Frye,Janice M. Fullerton,Janice M. Fullerton,Sébastien Gard,Julie Garnham,Fernando S. Goes,Maria Grigoroiu-Serbanescu,Paul Grof,Ryota Hashimoto,Joanna Hauser,Stefan Herms,Stefan Herms,Per Hoffmann,Per Hoffmann,Andrea Hofmann,Stéphane Jamain,Esther Jiménez,Jean-Pierre Kahn,Layla Kassem,Po-Hsiu Kuo,Tadafumi Kato,John R. Kelsoe,Sarah Kittel-Schneider,Sebastian Kliwicki,Barbara König,Ichiro Kusumi,Gonzalo Laje,Mikael Landén,Mikael Landén,Catharina Lavebratt,Marion Leboyer,Susan G. Leckband,Alfonso Tortorella,Mirko Manchia,Mirko Manchia,Lina Martinsson,Michael McCarthy,Michael McCarthy,Susan L. McElroy,Francesc Colom,Marina Mitjans,Marina Mitjans,Francis M. Mondimore,Palmiero Monteleone,Palmiero Monteleone,Caroline M. Nievergelt,Markus M. Nöthen,Tomas Novak,Claire O'Donovan,Norio Ozaki,Urban Ösby,Andrea Pfennig,James B. Potash,Andreas Reif,Eva Z. Reininghaus,Guy A. Rouleau,Janusz K. Rybakowski,Martin Schalling,Peter R. Schofield,Peter R. Schofield,Barbara W. Schweizer,Giovanni Severino,Paul D. Shilling,Katzutaka Shimoda,Christian Simhandl,Claire Slaney,Alessio Squassina,Thomas Stamm,Pavla Stopkova,Mario Maj,Gustavo Turecki,Eduard Vieta,Julia Volkert,Stephanie H. Witt,Adam Wright,Peter P. Zandi,Philip B. Mitchell,Michael Bauer,Martin Alda,Marcella Rietschel,Francis J. McMahon,Thomas G. Schulze,Bernhard T. Baune +126 more
TL;DR: Evidence is provided for a negative association between high genetic loading for SCZ and poor response to lithium in patients with BPAD, suggesting the potential for translational research aimed at personalized prescribing of lithium.