S
Seraya Maouche
Researcher at Pierre-and-Marie-Curie University
Publications - 12
Citations - 4926
Seraya Maouche is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 11, co-authored 12 publications receiving 4523 citations. Previous affiliations of Seraya Maouche include Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico & University of Lübeck.
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Journal ArticleDOI
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Heribert Schunkert,Inke R. König,Sekar Kathiresan,Muredach P. Reilly,Themistocles L. Assimes,Hilma Holm,Michael Preuss,Alexandre F.R. Stewart,Maja Barbalić,Christian Gieger,Devin Absher,Zouhair Aherrahrou,Hooman Allayee,David Altshuler,Sonia S. Anand,Karl Andersen,Jeffrey L. Anderson,Diego Ardissino,Stephen G. Ball,Anthony J. Balmforth,Timothy A. Barnes,Diane M. Becker,Lewis C. Becker,Klaus Berger,Joshua C. Bis,S. Matthijs Boekholdt,Eric Boerwinkle,Peter S. Braund,Morris J. Brown,Mary Susan Burnett,Ian Buysschaert,John F. Carlquist,Li Chen,Sven Cichon,Veryan Codd,Robert W. Davies,George Dedoussis,Abbas Dehghan,Serkalem Demissie,Joseph M. Devaney,Patrick Diemert,Ron Do,Angela Doering,Sandra Eifert,Nour Eddine El Mokhtari,Stephen G. Ellis,Roberto Elosua,James C. Engert,Stephen E. Epstein,Ulf de Faire,Marcus Fischer,Aaron R. Folsom,Jennifer Freyer,Bruna Gigante,Domenico Girelli,Solveig Gretarsdottir,Vilmundur Gudnason,Jeffrey R. Gulcher,Eran Halperin,Naomi Hammond,Stanley L. Hazen,Albert Hofman,Benjamin D. Horne,Thomas Illig,Carlos Iribarren,Gregory T. Jones,J. Wouter Jukema,Michael A. Kaiser,Lee M. Kaplan,John J.P. Kastelein,Kay-Tee Khaw,Joshua W. Knowles,G. Kolovou,Augustine Kong,Reijo Laaksonen,Diether Lambrechts,Karin Leander,Guillaume Lettre,Mingyao Li,Wolfgang Lieb,Christina Loley,Andrew J. Lotery,Pier Mannuccio Mannucci,Seraya Maouche,Nicola Martinelli,Pascal P. McKeown,Christa Meisinger,Thomas Meitinger,Olle Melander,Pier Angelica Merlini,Vincent Mooser,Thomas M. Morgan,Thomas W. Mühleisen,Joseph B. Muhlestein,Thomas Münzel,Kiran Musunuru,Janja Nahrstaedt,Christopher P. Nelson,Markus M. Nöthen,Oliviero Olivieri,Riyaz S. Patel,Christopher Patterson,Annette Peters,Flora Peyvandi,Liming Qu,Arshed A. Quyyumi,Daniel J. Rader,Loukianos S. Rallidis,Catherine M. Rice,Frits R. Rosendaal,Diana Rubin,Veikko Salomaa,M. Lourdes Sampietro,M. S. Sandhu,Eric E. Schadt,Arne Scḧsignfer,Arne Schillert,Stefan Schreiber,Jürgen Schrezenmeir,Stephen M. Schwartz,David S. Siscovick,Mohan U. Sivananthan,Suthesh Sivapalaratnam,Albert V. Smith,Tamara B. Smith,Jaapjan D. Snoep,Nicole Soranzo,John A. Spertus,Klaus Stark,Kathy Stirrups,Monika Stoll,W.H. Wilson Tang,Stephanie Tennstedt,Gudmundur Thorgeirsson,Gudmar Thorleifsson,Maciej Tomaszewski,André G. Uitterlinden,Andre M. van Rij,Benjamin F. Voight,Nicholas J. Wareham,George A. Wells,H.-Erich Wichmann,Philipp S. Wild,Christina Willenborg,Jaqueline C M Witteman,Benjamin J. Wright,Shu Ye,Tanja Zeller,Andreas Ziegler,François Cambien,Alison H. Goodall,L. Adrienne Cupples,Thomas Quertermous,Winfried Mäsignrz,Christian Hengstenberg,Stefan Blankenberg,Willem H. Ouwehand,Alistair S. Hall,Panos Deloukas,John R. Thompson,Kari Stefansson,Robert Roberts,Unnur Thorsteinsdottir,Christopher J. O'Donnell,Ruth McPherson,Jeanette Erdmann,Nilesh J. Samani +166 more
TL;DR: This paper performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals.
Journal ArticleDOI
Large-scale association analysis identifies new risk loci for coronary artery disease
Panos Deloukas,Stavroula Kanoni,Christina Willenborg,Martin Farrall,Themistocles L. Assimes,John R. Thompson,Erik Ingelsson,Danish Saleheen,Danish Saleheen,Jeanette Erdmann,Benjamin A. Goldstein,Kathleen Stirrups,Inke R. König,Jean-Baptiste Cazier,Åsa Johansson,Alistair S. Hall,Jong-Young Lee,Cristen J. Willer,John C. Chambers,Tõnu Esko,Lasse Folkersen,Anuj Goel,Elin Grundberg,Aki S. Havulinna,Weang K. Ho,Jemma C. Hopewell,Niclas Eriksson,Marcus E. Kleber,Kati Kristiansson,Per Lundmark,Leo-Pekka Lyytikäinen,Suzanne Rafelt,Dmitry Shungin,Dmitry Shungin,Rona J. Strawbridge,Gudmar Thorleifsson,Emmi Tikkanen,Emmi Tikkanen,Natalie R. van Zuydam,Benjamin F. Voight,Lindsay L. Waite,Weihua Zhang,Andreas Ziegler,Devin Absher,David Altshuler,David Altshuler,Anthony J. Balmforth,Inês Barroso,Inês Barroso,Peter S. Braund,Peter S. Braund,Christof Burgdorf,Simone Claudi-Boehm,David G. Cox,Maria Dimitriou,Ron Do,Ron Do,Alex S. F. Doney,Nour Eddine El Mokhtari,Per Eriksson,Krista Fischer,Pierre Fontanillas,Anders Franco-Cereceda,Bruna Gigante,Leif Groop,Stefan Gustafsson,Jorg Hager,Göran Hallmans,Bok Ghee Han,Sarah E. Hunt,Hyun Min Kang,Thomas Illig,Thorsten Kessler,Joshua W. Knowles,Genovefa Kolovou,Johanna Kuusisto,Claudia Langenberg,Cordelia Langford,Karin Leander,Marja-Liisa Lokki,Anders Lundmark,Mark I. McCarthy,Christa Meisinger,Olle Melander,Evelin Mihailov,Seraya Maouche,Andrew D. Morris,Martina Müller-Nurasyid,Kjell Nikus,John F. Peden,N. William Rayner,Asif Rasheed,Silke Rosinger,Diana Rubin,Moritz P. Rumpf,Arne Schäfer,Mohan U. Sivananthan,Ci Song,Alexandre F.R. Stewart,Sian Tsung Tan,Gudmundur Thorgeirsson,C. Ellen van der Schoot,Peter Wagner,Peter Wagner,George A. Wells,Philipp S. Wild,Tsun-Po Yang,Philippe Amouyel,Dominique Arveiler,Hanneke Basart,Michael Boehnke,Eric Boerwinkle,Paolo Brambilla,François Cambien,Adrienne Cupples,Adrienne Cupples,Ulf de Faire,Abbas Dehghan,Patrick Diemert,Stephen E. Epstein,Alun Evans,Marco M Ferrario,Jean Ferrières,Dominique Gauguier,Dominique Gauguier,Alan S. Go,Alison H. Goodall,Alison H. Goodall,Villi Gudnason,Stanley L. Hazen,Hilma Holm,Carlos Iribarren,Yangsoo Jang,Mika Kähönen,Frank Kee,Hyo-Soo Kim,Norman Klopp,Wolfgang Koenig,Wolfgang Kratzer,Kari Kuulasmaa,Markku Laakso,Reijo Laaksonen,Jiyoung Lee,Lars Lind,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Sarah Parish,Jeong E. Park,Nancy L. Pedersen,Annette Peters,Thomas Quertermous,Daniel J. Rader,Veikko Salomaa,Eric E. Schadt,Svati H. Shah,Juha Sinisalo,Klaus Stark,Kari Stefansson,Kari Stefansson,David-Alexandre Trégouët,Jarmo Virtamo,Lars Wallentin,Nicholas J. Wareham,Martina E. Zimmermann,Markku S. Nieminen,Christian Hengstenberg,Manjinder S. Sandhu,Manjinder S. Sandhu,Tomi Pastinen,Ann-Christine Syvänen,G. Kees Hovingh,George Dedoussis,Paul W. Franks,Paul W. Franks,Paul W. Franks,Terho Lehtimäki,Andres Metspalu,Pierre Zalloua,Agneta Siegbahn,Stefan Schreiber,Samuli Ripatti,Samuli Ripatti,Stefan Blankenberg,Markus Perola,Robert Clarke,Bernhard O. Boehm,Christopher J. O'Donnell,Muredach P. Reilly,Winfried März,Winfried März,Rory Collins,Sekar Kathiresan,Sekar Kathiresan,Anders Hamsten,Jaspal S. Kooner,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,John Danesh,Colin N. A. Palmer,Robert Roberts,Hugh Watkins,Heribert Schunkert,Nilesh J. Samani,Nilesh J. Samani +204 more
TL;DR: An association analysis in CAD cases and controls identifies 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants strongly associated with CAD at a 5% false discovery rate (FDR).
Journal ArticleDOI
Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility
Tanja Zeller,Philipp S. Wild,Silke Szymczak,Maxime Rotival,Arne Schillert,Raphaële Castagné,Seraya Maouche,Marine Germain,Karl J. Lackner,Heidi Rossmann,Medea S. Eleftheriadis,C. Sinning,Renate B. Schnabel,Edith Lubos,Detlev Mennerich,Werner Rust,Claire Perret,Carole Proust,Viviane Nicaud,Joseph Loscalzo,Norbert Hubner,David-Alexandre Trégouët,Thomas Münzel,Andreas Ziegler,Laurence Tiret,Stefan Blankenberg,François Cambien +26 more
TL;DR: This study demonstrates that the monocyte transcriptome is a potent integrator of genetic and non-genetic influences of relevance for disease pathophysiology and risk assessment.
Journal ArticleDOI
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
Matthias Heinig,Enrico Petretto,Chris Wallace,Leonardo Bottolo,Maxime Rotival,Han Lu,Yoyo Li,Rizwan Sarwar,Sarah R. Langley,Anja Bauerfeind,Oliver Hummel,Young-Ae Lee,Young-Ae Lee,Svetlana Paskas,Carola Rintisch,Kathrin Saar,Jason D. Cooper,Rachel Buchan,Elizabeth E. Gray,Jason G. Cyster,Jeanette Erdmann,Christian Hengstenberg,Seraya Maouche,Willem H. Ouwehand,Willem H. Ouwehand,Catherine M. Rice,Nilesh J. Samani,Heribert Schunkert,Alison H. Goodall,Herbert Schulz,Helge G. Roider,Martin Vingron,Stefan Blankenberg,Thomas Münzel,Tanja Zeller,Silke Szymczak,Andreas Ziegler,Laurence Tiret,Deborah J. Smyth,Michal Pravenec,Timothy J. Aitman,François Cambien,David Clayton,John A. Todd,Norbert Hubner,Norbert Hubner,Stuart A. Cook,Stuart A. Cook +47 more
TL;DR: The use of integrated genome-wide approaches across seven rat tissues to identify gene networks and the loci underlying their regulation implicate IRF7 network genes and their regulatory locus in the pathogenesis of T1D.
Journal ArticleDOI
Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease
Adam S. Butterworth,Peter S. Braund,Martin Farrall,Robert J. Hardwick,Danish Saleheen,J F Peden,Nicole Soranzo,John C. Chambers,Suthesh Sivapalaratnam,Marcus E. Kleber,Brendan J. Keating,Atif Qasim,Norman Klopp,Jeanette Erdmann,Themistocles L. Assimes,Stephen G. Ball,Anthony J. Balmforth,Timothy A. Barnes,Hanneke Basart,Jens Baumert,Connie R. Bezzina,Eric Boerwinkle,Bernhard O. Boehm,Jessy Brocheton,Peter Bugert,François Cambien,Robert Clarke,Veryan Codd,Rory Collins,David Couper,L. Adrienne Cupples,Jonas S.S.G. de Jong,Patrick Diemert,Kenechi Ejebe,Clara C. Elbers,Paul Elliott,Myriam Fornage,Maria Grazia Franzosi,Philippe M. Frossard,Stephen F. Garner,Anuj Goel,Alison H. Goodall,Christian Hengstenberg,Sarah E. Hunt,John J.P. Kastelein,Olaf H. Klungel,Harald Klüterr,Kerstin Koch,Inke R. König,Angad S. Kooner,Reijo Laaksonen,Mark Lathrop,Mingyao Li,Kiang Liu,Ruth McPherson,Muntaser D. Musameh,Solomon K. Musani,Christopher P. Nelson,Christopher J. O'Donnell,Halit Ongen,George J. Papanicolaou,Annette Peters,Bas J M Peters,Simon C. Potter,Bruce M. Psaty,Liming Qu,Daniel J. Rader,Asif Rasheed,Catherine M. Rice,James Scott,Udo Seedorf,Joban Sehmi,Nona Sotoodehnia,Klaus Stark,Jonathan Stephens,C. Ellen van der Schoot,Yvonne T. van der Schouw,Unnur Thorsteinsdottir,Maciej Tomaszewski,Pim van der Harst,Ramachandran S. Vasan,Arthur A.M. Wilde,Christina Willenborg,Bernhard R. Winkelmann,Moazzam Zaidi,Weihua Zhang,Andreas Ziegler,Paul I.W. de Bakker,Wolfgang Koenig,Winfried März,Mieke D. Trip,Muredach P. Reilly,Sekar Kathiresan,Heribert Schunkert,Anders Hamsten,Alistair S. Hall,Jaspal S. Kooner,Simon G. Thompson,John R. Thompson,Panos Deloukas,Willem H. Ouwehand,Hugh Watkins,John Danesh,Nilesh J. Samani,Timothy A. Barnes,Timothy A. Barnes,Suzanne Rafelt,Nienke Bruinsma,Lukas R.C. Dekker,José P. Henriques,Karel T. Koch,Karel T. Koch,Robbert J. de Winter,Marco Alings,Cor F. Allaart,Anton P.M. Gorgels,Freek W. Verheugt,Martina Mueller,Christa Meisinger,Stephanie DerOhannessian,Nehal N. Mehta,Jane F. Ferguson,Hakon Hakonarson,William H. Matthai,Robert L. Wilensky,Jemma C. Hopewell,Sarah Parish,Pamela Linksted,J. Notman,Hector M. González,A. Young,T. Ostley,A. Munday,N. Goodwin,V. Verdon,Svati H. Shah,Laura K. Cobb,Cathryn Edwards,Carol A. Mathews,R. Gunter,J. Benham,Christopher Davies,M. Cobb,J. Crowther,Arthur Mark Richards,M. Silver,S. Tochlin,S. Mozley,Sarah Clark,M. Radley,K. Kourellias,Per Georg Olsson,Simona Barlera,Gianni Tognoni,Stephan Rust,Gerd Assmann,Simon Heath,Diana Zelenika,Ivo Gut,Fiona Green,John F. Peden,Anette Aly,Karolina Anner,Karin Björklund,Gun Blomgren,Barbro Cederschiöld,Karin Danell-Toverud,Per Eriksson,Ulla Grundstedt,Merja Heinonen,Mai Lis Hellénius,Ferdinand M. van't Hooft,Karin Husman,Jacob Lagercrantz,Anita Larsson,Malin Larsson,Magnus Mossfeldt,Anders Mälarstig,Gunnar O Olsson,Maria Sabater-Lleal,Bengt Sennblad,Angela Silveira,Rona J. Strawbridge,Birgitta Söderholm,John Öhrvik,Khan Shah Zaman,Nadeem Hayat Mallick,Muhammad Azhar,Abdus Samad,M. Ishaq,Nabi Shah,Maria Samuel,Muredach P. Reilly,Muredach P. Reilly,Hilma Holm,Michael Preuss,Alexandre F.R. Stewart,Maja Barbalić,Christian Gieger,Devin Absher,Zouhair Aherrahrou,Hooman Allayee,David Altshuler,Sonia S. Anand,Karl Andersen,Jeffrey L. Anderson,Diego Ardissino,Lewis C. Becker,Diane M. Becker,Klaus Berger,Joshua C. Bis,S. Matthijs Boekholdt,Morris J. Brown,Mary Susan Burnett,Ian Buysschaert,John F. Carlquist,Li Chen,Robert W. Davies,George Dedoussis,Abbas Dehghan,Serkalem Demissie,Joseph M. Devaney,Ron Do,Angela Doering,Nour Eddine El Mokhtari,Stephen G. Ellis,Roberto Elosua,James C. Engert,Stephen E. Epstein,Ulf de Faire,Marcus Fischer,Aaron R. Folsom,Jennifer Freyer,Bruna Gigante,Domenico Girelli,Solveig Gretarsdottir,Vilmundur Gudnason,Jeffrey R. Gulcher,Stephanie Tennstedt,Eran Halperin,Naomi Hammond,Stanley L. Hazen,Albert Hofman,Benjamin D. Horne,Thomas Illig,Carlos Iribarren,Gregory T. Jones,J. Wouter Jukema,Michael A. Kaiser,Lee M. Kaplan,Kay-Tee Khaw,Joshua W. Knowles,G. Kolovou,Augustine Kong,Diether Lambrechts,Karin Leander,Wolfgang Lieb,Guillaume Lettre,Christina Loley,Andrew J. Lotery,Pier Mannuccio Mannucci,Seraya Maouche,Nicola Martinelli,Pascal P. McKeown,Thomas Meitinger,Olle Melander,Pier Angelica Merlini,Vincent Mooser,Thomas M. Morgan,Thomas W. Mühleisen,Joseph B. Muhlestein,Kiran Musunuru,Janja Nahrstaedt,Markus M. Nöthen,Oliviero Olivieri,Flora Peyvandi,Riyaz S. Patel,Christopher Patterson,Arshed A. Quyyumi,Loukianos S. Rallidis,Frits R. Roosendaal,Diana Rubin,Veikko Salomaa,M. Lourdes Sampietro,M. S. Sandhu,Eric E. Schadt,Arne Schäfer,Arne Schillert,Stefan Schreiber,Jürgen Schrezenmeir,Stephen M. Schwartz,David S. Siscovick,Mohan U. Sivananthan,Albert V. Smith,Tamara B. Smith,Jaapjan D. Snoep,John A. Spertus,Kari Stefansson,Kathy Stirrups,Monika Stoll,W.H. Wilson Tang,Gudmundur Thorgeirsson,Gudmar Thorleifsson,André G. Uitterlinden,Andre M. van Rij,Benjamin F. Voight,Nicholas J. Wareham,George A. Wells,H.-Erich Wichmann,Jaqueline C M Witteman,Benjamin J. Wright,Shu Ye,Thomas Quertermous,Stefan Blankenberg,Robert Roberts,N. Charlotte Onland-Moret,Jessica van Setten,W. M. Monique Verschuren,Jolanda M. A. Boer,Cisca Wijmenga,Marten H. Hofker,Anke-Hilse Maitland-van der Zee,Anthonius de Boer,Diederick E. Grobbee,Tony Attwood,Stephanie Belz,Peter S. Braund,Peter S. Braund,Jason D. Cooper,Abi Crisp-Hihn,Nicola Foad,Jay Gracey,Emma Gray,Rhian Gwilliams,Susanne Heimerl,Jennifer Jolley,Unni Krishnan,Heather Lloyd-Jones,Ingrid Lugauer,Per Lundmark,Jasbir S. Moore,David Muir,Elizabeth Murray,Jessica Neudert,David Niblett,Karen O'Leary,Helen Pollard,Angela Rankin,Catherine M. Rice,Hendrik B. Sager,Jennifer G. Sambrook,Gerd Schmitz,Michael Scholz,Laura Schroeder,Ann Christine Syvannen,Chris Wallace +355 more
TL;DR: This large-scale gene-centric analysis has identified several novel genes for CAD that relate to diverse biochemical and cellular functions and clarified the literature with regard to many previously suggested genes.