J
Julia Hofmann
Researcher at Goethe University Frankfurt
Publications - 9
Citations - 1320
Julia Hofmann is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Acute leukemia & Multiplex ligation-dependent probe amplification. The author has an hindex of 8, co-authored 9 publications receiving 1231 citations. Previous affiliations of Julia Hofmann include Charité.
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Journal ArticleDOI
The MLL recombinome of acute leukemias in 2013
Claus Meyer,Julia Hofmann,Thomas Burmeister,Daniela Gröger,T S Park,Mariana Emerenciano,M. Pombo De Oliveira,Aline Renneville,Patrick Villarese,Elizabeth Macintyre,Hélène Cavé,Emmanuelle Clappier,K. Mass-Malo,Jan Zuna,Jan Trka,E De Braekeleer,M. De Braekeleer,S H Oh,Grigory Tsaur,L Fechina,V H J van der Velden,J J M van Dongen,Eric Delabesse,Renata Binato,Mara Silva,AM Kustanovich,Olga V. Aleinikova,Marian H. Harris,T Lund-Aho,Vesa Juvonen,Olaf Heidenreich,Josef Vormoor,William W.L. Choi,Marie Jarošová,A. Kolenova,Clara Bueno,Pablo Menendez,S. Wehner,Cornelia Eckert,Pascaline Talmant,Sylvie Tondeur,Eric Lippert,E. Launay,Catherine Henry,Paola Ballerini,H. Lapillone,Mary Callanan,Jean Michel Cayuela,Charles Herbaux,Giovanni Cazzaniga,P. M. Kakadiya,Stefan K. Bohlander,Martina Ahlmann,Jong Rak Choi,Paula Gameiro,Dongsoon Lee,Juergen Krauter,Pascale Cornillet-Lefebvre,G te Kronnie,Beat W. Schäfer,S. Kubetzko,Cristina N. Alonso,U. Zur Stadt,Rosemary Sutton,N. C. Venn,Shai Izraeli,Luba Trakhtenbrot,H. O. Madsen,P. Archer,Jeremy Hancock,Nuno Cerveira,Manuel R. Teixeira,L Lo Nigro,Anja Möricke,Martin Stanulla,Martin Schrappe,Lukasz Sedek,Tomasz Szczepański,Christian M. Zwaan,Eva A. Coenen,M.M. van den Heuvel-Eibrink,Sabine Strehl,Michael Dworzak,Renate Panzer-Grümayer,Theodor Dingermann,Thomas Klingebiel,Rolf Marschalek +86 more
TL;DR: Long-distance inverse-polymerase chain reaction was used to characterize the chromosomal rearrangement of individual acute leukemia patients and revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level.
ORIGINAL ARTICLE New insights to the MLL recombinome of acute leukemias
Cathy Meyer,Eric Kowarz,Julia Hofmann,Aline Renneville,Jan Zuna,Jan Trka,R Ben Abdelali,Elisabeth Macintyre,E De Braekeleer,L Trakhtenbrot,L Lo Nigro,G Tsaur,L Fechina,Tomasz Szczepański,Sabine Strehl,D Ilencikova,M Molkentin,Thomas Burmeister,Theodor Dingermann,Thomas Klingebiel,Rolf Marschalek,Erasmus Mc,Michael Smith +22 more
TL;DR: The genetic network of reciprocal MLL gene fusions deriving from complex rearrangements is described for the first time, and the distribution of MLL breakpoints for clinical subtypes and fused translocation partner genes (TPGs) will be presented, including novel MLL fusion genes.
Journal ArticleDOI
New insights to the MLL recombinome of acute leukemias
Christian Meyer,Eric Kowarz,Julia Hofmann,Aline Renneville,Jan Zuna,Jan Trka,R. Ben Abdelali,Elizabeth Macintyre,E De Braekeleer,E De Braekeleer,M. De Braekeleer,M. De Braekeleer,Eric Delabesse,M. P. de Oliveira,Hélène Cavé,Emmanuelle Clappier,J J M van Dongen,Brian V. Balgobind,M M van den Heuvel-Eibrink,H B Beverloo,Renate Panzer-Grümayer,Andrea Teigler-Schlegel,Jochen Harbott,Eigil Kjeldsen,Susanne Schnittger,Ulrike Koehl,Bernd Gruhn,Olaf Heidenreich,Li Chong Chan,Sze-Fai Yip,Martin Krzywinski,C Eckert,Anja Möricke,Martin Schrappe,Cristina N. Alonso,Beat W. Schäfer,Jürgen Krauter,Dean A. Lee,U zur Stadt,G te Kronnie,Rosemary Sutton,Shai Izraeli,L. Trakhtenbrot,L. Trakhtenbrot,L Lo Nigro,Grigory Tsaur,Larisa Fechina,Tomasz Szczepański,Sabine Strehl,D. Ilencikova,Mara Molkentin,Thomas Burmeister,Theodor Dingermann,T. Klingebiel,Rolf Marschalek +54 more
TL;DR: In this paper, the distribution of MLL breakpoints for clinical subtypes (acute lymphoblastic leukemia, acute myeloid leukemia, pediatric and adult) and fused translocation partner genes (TPGs) were presented, including novel MLL fusion genes.
Journal ArticleDOI
The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia - results from the GMALL study group
Thomas Burmeister,Claus Meyer,Stefan Schwartz,Julia Hofmann,Mara Molkentin,Eric Kowarz,Björn Schneider,Thorsten Raff,Richard Reinhardt,Nicola Gökbuget,Dieter Hoelzer,Eckhard Thiel,Rolf Marschalek +12 more
TL;DR: A genetic characterization of 184 BCR-ABL(-) CD10(-) adult ALL cases diagnosed between 2001 and 2007 is presented, revealing 2 major breakpoint cluster regions in the MLL gene.
Journal ArticleDOI
Evidence-based RT-PCR methods for the detection of the 8 most common MLL aberrations in acute leukemias.
TL;DR: RT-PCR methods for the reliable detection of the 8 most common MLL aberrations, together accounting for around 90% of MLL-r cases, are developed.