E
Eva A. Coenen
Researcher at Boston Children's Hospital
Publications - 19
Citations - 776
Eva A. Coenen is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 8, co-authored 19 publications receiving 707 citations. Previous affiliations of Eva A. Coenen include Erasmus University Rotterdam.
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Journal ArticleDOI
The MLL recombinome of acute leukemias in 2013
Claus Meyer,Julia Hofmann,Thomas Burmeister,Daniela Gröger,T S Park,Mariana Emerenciano,M. Pombo De Oliveira,Aline Renneville,Patrick Villarese,Elizabeth Macintyre,Hélène Cavé,Emmanuelle Clappier,K. Mass-Malo,Jan Zuna,Jan Trka,E De Braekeleer,M. De Braekeleer,S H Oh,Grigory Tsaur,L Fechina,V H J van der Velden,J J M van Dongen,Eric Delabesse,Renata Binato,Mara Silva,AM Kustanovich,Olga V. Aleinikova,Marian H. Harris,T Lund-Aho,Vesa Juvonen,Olaf Heidenreich,Josef Vormoor,William W.L. Choi,Marie Jarošová,A. Kolenova,Clara Bueno,Pablo Menendez,S. Wehner,Cornelia Eckert,Pascaline Talmant,Sylvie Tondeur,Eric Lippert,E. Launay,Catherine Henry,Paola Ballerini,H. Lapillone,Mary Callanan,Jean Michel Cayuela,Charles Herbaux,Giovanni Cazzaniga,P. M. Kakadiya,Stefan K. Bohlander,Martina Ahlmann,Jong Rak Choi,Paula Gameiro,Dongsoon Lee,Juergen Krauter,Pascale Cornillet-Lefebvre,G te Kronnie,Beat W. Schäfer,S. Kubetzko,Cristina N. Alonso,U. Zur Stadt,Rosemary Sutton,N. C. Venn,Shai Izraeli,Luba Trakhtenbrot,H. O. Madsen,P. Archer,Jeremy Hancock,Nuno Cerveira,Manuel R. Teixeira,L Lo Nigro,Anja Möricke,Martin Stanulla,Martin Schrappe,Lukasz Sedek,Tomasz Szczepański,Christian M. Zwaan,Eva A. Coenen,M.M. van den Heuvel-Eibrink,Sabine Strehl,Michael Dworzak,Renate Panzer-Grümayer,Theodor Dingermann,Thomas Klingebiel,Rolf Marschalek +86 more
TL;DR: Long-distance inverse-polymerase chain reaction was used to characterize the chromosomal rearrangement of individual acute leukemia patients and revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level.
Journal ArticleDOI
Pediatric acute myeloid leukemia with t(8;16)(p11;p13), a distinct clinical and biological entity: a collaborative study by the International-Berlin-Frankfurt-Munster AML-study group
Eva A. Coenen,C. Michel Zwaan,Dirk Reinhardt,Christine J. Harrison,Oskar A. Haas,Valerie de Haas,Vladimír Mihál,Barbara De Moerloose,Marta Jeison,Jeffrey E. Rubnitz,Daisuke Tomizawa,Donna L. Johnston,Donna L. Johnston,Todd A. Alonzo,Todd A. Alonzo,Henrik Hasle,Anne Auvrignon,Michael Dworzak,Andrea Pession,Vincent H.J. van der Velden,John Swansbury,Kit Fai Wong,Kiminori Terui,Süreyya Savaşan,Mark Winstanley,Goda Vaitkeviciene,Martin Zimmermann,Rob Pieters,Marry M. van den Heuvel-Eibrink +28 more
TL;DR: Pediatric t(8;16)(p11;p13) AML is a rare entity defined by a unique gene expression signature and distinct clinical features in whom spontaneous remissions occur in a subset of neonatal cases.
Journal ArticleDOI
t(6;9)(p22;q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients
Julie Damgaard Sandahl,Eva A. Coenen,Erik Forestier,Jochen Harbott,Bertil Johansson,Gitte Kerndrup,Souichi Adachi,Anne Auvrignon,H. Berna Beverloo,Jean Michel Cayuela,Lucy Chilton,Maarten Fornerod,Valerie de Haas,Christine J. Harrison,Hiroto Inaba,Gertjan J.L. Kaspers,Der Cherng Liang,Franco Locatelli,Riccardo Masetti,Christine Perot,Susana C. Raimondi,Katarina Reinhardt,Daisuke Tomizawa,Nils von Neuhoff,Marco Zecca,C. Michel Zwaan,Marry M. van den Heuvel-Eibrink,Henrik Hasle +27 more
TL;DR: T(6;9)/DEK-NUP214 represents a unique subtype of acute myeloid leukemia with a high risk of relapse, high frequency of FLT3-ITD, and a specific gene expression signature.
Journal ArticleDOI
Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study
Eva A. Coenen,Susana C. Raimondi,Susana C. Raimondi,Jochen Harbott,Martin Zimmermann,Todd A. Alonzo,Anne Auvrignon,H. Berna Beverloo,Myron Chang,Ursula Creutzig,Michael Dworzak,Erik Forestier,Brenda Gibson,Henrik Hasle,Christine J. Harrison,Nyla A. Heerema,Nyla A. Heerema,Gertjan J.L. Kaspers,Anna Leszl,Nathalia Litvinko,Luca Lo Nigro,Akira Morimoto,Christine Perot,Dirk Reinhardt,Jeffrey E. Rubnitz,Franklin O. Smith,Franklin O. Smith,Jan Stary,Irina Stasevich,Sabine Strehl,Takashi Taga,Daisuke Tomizawa,David Webb,Zuzana Zemanova,Rob Pieters,C. Michel Zwaan,Marry M. van den Heuvel-Eibrink +36 more
TL;DR: Like TP, specific ACAs have independent prognostic significance in pediatric 11q23/MLL-rearranged AML, and the mechanism underlying these prognostic differences should be studied.
Journal ArticleDOI
Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia
Anna M. Aalbers,Anna M. Aalbers,Anna M. Aalbers,Rodrigo T. Calado,Rodrigo T. Calado,Neal S. Young,Christian M. Zwaan,Chengqing Wu,Sachiko Kajigaya,Eva A. Coenen,André Baruchel,Karin Geleijns,V de Haas,Gertjan J.L. Kaspers,Taco W. Kuijpers,Taco W. Kuijpers,Dirk Reinhardt,Jan Trka,Martin Zimmermann,Rob Pieters,V H J van der Velden,M M van den Heuvel-Eibrink +21 more
TL;DR: The frequency of mutations in the Telomerase complex genes TERT, telomerase reverse transcriptase, and TERC, the RNA template of the telomersase complex, in pediatric AML was assessed and telomere length was measured at diagnosis and its relationship with clinical and molecular characteristics and outcome was determined.