K
Kaori Sango
Researcher at Harvard University
Publications - 6
Citations - 981
Kaori Sango is an academic researcher from Harvard University. The author has contributed to research in topics: Epitope & CTL*. The author has an hindex of 6, co-authored 6 publications receiving 960 citations.
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Journal ArticleDOI
Consistent Cytotoxic-T-Lymphocyte Targeting of Immunodominant Regions in Human Immunodeficiency Virus across Multiple Ethnicities
Nicole Frahm,Bette T. Korber,Bette T. Korber,C. M. Adams,James J. Szinger,Rika Draenert,Marylyn M. Addo,Margaret E. Feeney,Karina Yusim,Kaori Sango,Nancy V. Brown,Devi SenGupta,Alicja Piechocka-Trocha,T. Simonis,F. M. Marincola,Alysse G. Wurcel,David Stone,Christopher J. Russell,P. Adolf,Daniel E. Cohen,Timothy Roach,A. StJohn,Ashok Khatri,K. Davis,James I. Mullins,Philip J. R. Goulder,Bruce D. Walker,Christian Brander +27 more
TL;DR: Factors that contribute to the immunogenicity of these highly targeted and relatively conserved sequences in HIV that may represent promising vaccine candidates for ethnically heterogeneous populations are identified.
Journal ArticleDOI
Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
Nicole Frahm,Photini Kiepiela,Sharon Adams,Caitlyn Linde,Hannah S. Hewitt,Kaori Sango,Margaret E. Feeney,Marylyn M. Addo,Mathias Lichterfeld,Matthew P. Lahaie,Eunice Pae,Alysse G. Wurcel,Alysse G. Wurcel,Timothy Roach,M. Anne St. John,Marcus Altfeld,Francesco M. Marincola,Corey Moore,Simon Mallal,Mary Carrington,David Heckerman,Todd M. Allen,James I. Mullins,Bette T. Korber,Bette T. Korber,Philip J. R. Goulder,Philip J. R. Goulder,Bruce D. Walker,Bruce D. Walker,Christian Brander +29 more
TL;DR: Analysis of cytotoxic T lymphocyte responses restricted by HLA-B*1503 suggests that subdominant responses can contribute to in vivo viral control and that high HLA allele frequencies may drive the elimination ofSubdominant yet effective epitopes from circulating viral populations.
Journal ArticleDOI
Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses
Florian Bihl,Nicole Frahm,Loriana Di Giammarino,John Sidney,Mina John,Karina Yusim,Tonia Woodberry,Kaori Sango,Hannah S. Hewitt,Leah M. Henry,Caitlyn Linde,John V. Chisholm,Tauheed Zaman,Eunice Pae,Simon Mallal,Bruce D. Walker,Alessandro Sette,Bette T. Korber,David Heckerman,Christian Brander +19 more
TL;DR: The data support the important role of HLA-B alleles in antiviral immunity and afford a better understanding of the factors contributing to inter- and intraindividual immunodominance.
Journal ArticleDOI
Extensive HLA class I allele promiscuity among viral CTL epitopes
Nicole Frahm,Karina Yusim,Todd J. Suscovich,Sharon Adams,John Sidney,Peter T. Hraber,Hannah S. Hewitt,Caitlyn Linde,Daniel G. Kavanagh,Tonia Woodberry,Leah M. Henry,Kellie Faircloth,Jennifer Listgarten,Carl M. Kadie,Nebojsa Jojic,Kaori Sango,Nancy V. Brown,Eunice Pae,M. Tauheed Zaman,Florian Bihl,Ashok Khatri,Mina John,Simon Mallal,Francesco M. Marincola,Bruce D. Walker,Bruce D. Walker,Alessandro Sette,David Heckerman,Bette T. Korber,Bette T. Korber,Christian Brander +30 more
TL;DR: Functional assays confirmed the frequent recognition of HLA class I‐restricted T cell epitopes on several alternative alleles across HLAclass I supertypes and encoded on different class I loci, suggesting promiscuous binding of T helper epitopes to MHC class II molecules.
Journal ArticleDOI
Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity.
Aviva Joseph,Jian Hua Zheng,Antonia Follenzi,Teresa P. DiLorenzo,Kaori Sango,Jaime Hyman,Ken Chen,Alicja Piechocka-Trocha,Alicja Piechocka-Trocha,Christian Brander,Christian Brander,Erik Hooijberg,Dario A. A. Vignali,Bruce D. Walker,Bruce D. Walker,Harris Goldstein +15 more
TL;DR: This work constructed lentiviral vectors encoding an HIV-1-specific TCR α and TCR β chains cloned from a CTL clone specific for an HIV Gag epitope, SL9, as a single transcript linked with a self-cleaving peptide and demonstrated that transduction with this lentivirus efficiently converted primary human CD8 lymphocytes into HIV- 1-specific CTLs with potent in vitro and in vivo HIV-2-specific activity.