Kaori Sango

TL;DR: Factors that contribute to the immunogenicity of these highly targeted and relatively conserved sequences in HIV that may represent promising vaccine candidates for ethnically heterogeneous populations are identified.

TL;DR: Analysis of cytotoxic T lymphocyte responses restricted by HLA-B*1503 suggests that subdominant responses can contribute to in vivo viral control and that high HLA allele frequencies may drive the elimination ofSubdominant yet effective epitopes from circulating viral populations.

TL;DR: The data support the important role of HLA-B alleles in antiviral immunity and afford a better understanding of the factors contributing to inter- and intraindividual immunodominance.

TL;DR: Functional assays confirmed the frequent recognition of HLA class I‐restricted T cell epitopes on several alternative alleles across HLAclass I supertypes and encoded on different class I loci, suggesting promiscuous binding of T helper epitopes to MHC class II molecules.

TL;DR: This work constructed lentiviral vectors encoding an HIV-1-specific TCR α and TCR β chains cloned from a CTL clone specific for an HIV Gag epitope, SL9, as a single transcript linked with a self-cleaving peptide and demonstrated that transduction with this lentivirus efficiently converted primary human CD8 lymphocytes into HIV- 1-specific CTLs with potent in vitro and in vivo HIV-2-specific activity.