K
Kasia Stepniewska
Researcher at University of Oxford
Publications - 170
Citations - 18318
Kasia Stepniewska is an academic researcher from University of Oxford. The author has contributed to research in topics: Malaria & Artesunate. The author has an hindex of 66, co-authored 151 publications receiving 16705 citations. Previous affiliations of Kasia Stepniewska include Lincoln's Inn & Wellcome Trust.
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Journal ArticleDOI
Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
Elizabeth A. Ashley,Mehul Dhorda,Rick M. Fairhurst,Chanaki Amaratunga,Pharath Lim,Seila Suon,Sokunthea Sreng,Jennifer M. Anderson,Mao S,Sam B,Chantha Sopha,Char Meng Chuor,Chea Nguon,Siv Sovannaroth,Sasithon Pukrittayakamee,Podjanee Jittamala,Kesinee Chotivanich,K Chutasmit,C Suchatsoonthorn,R Runcharoen,Tran Tinh Hien,Nguyen Thuy-Nhien,Thanh Nv,Nguyen Hoan Phu,Ye Htut,Han Kt,Kyin Hla Aye,Olugbenga A. Mokuolu,Rasaq Olaosebikan,Olaleke Oluwasegun Folaranmi,Mayfong Mayxay,Maniphone Khanthavong,Bouasy Hongvanthong,Paul N. Newton,M A Onyamboko,Caterina I. Fanello,Antoinette Tshefu,Neelima Mishra,Neena Valecha,Aung Pyae Phyo,François Nosten,Yi P,Rupam Tripura,Steffen Borrmann,Mahfudh Bashraheil,Judy Peshu,M A Faiz,Aniruddha Ghose,M A Hossain,Rasheda Samad,M. R. Rahman,Manal Hasan,Ashraful Islam,Olivo Miotto,Roberto Amato,Bronwyn MacInnis,Jim Stalker,Dominic P. Kwiatkowski,Zbynek Bozdech,Atthanee Jeeyapant,Phaik Yeong Cheah,Tharisara Sakulthaew,Jeremy Chalk,Benjamas Intharabut,Kamolrat Silamut,Lee Sj,Benchawan Vihokhern,Chanon Kunasol,Mallika Imwong,Joel Tarning,Taylor Wj,Shunmay Yeung,Charles J. Woodrow,Jennifer A. Flegg,Debashish Das,Jennifer L. Smith,Meera Venkatesan,Christopher V. Plowe,Kasia Stepniewska,Philippe J Guerin,Arjen M. Dondorp,Nicholas P. J. Day,Nicholas J. White +82 more
TL;DR: Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing, and the incidence of pretreatment and post-treatment gametocytemia was higher among patients with slow parasite clearance, suggesting greater potential for transmission.
Journal ArticleDOI
Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial.
TL;DR: Artesunate should become the treatment of choice for severe falciparum malaria in adults because it is more rapidly acting than intravenous quinine in terms of parasite clearance and is simpler to administer.
Journal ArticleDOI
Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study
Aung Pyae Phyo,Standwell Nkhoma,Kasia Stepniewska,Kasia Stepniewska,Elizabeth A. Ashley,Elizabeth A. Ashley,Shalini Nair,Rose McGready,Rose McGready,Carit Ler Moo,Salma Al-Saai,Arjen M. Dondorp,Arjen M. Dondorp,Khin Maung Lwin,Pratap Singhasivanon,Nicholas P. J. Day,Nicholas P. J. Day,Nicholas J. White,Nicholas J. White,Tim J. Anderson,François Nosten,François Nosten +21 more
TL;DR: Genetically determined artemisinin resistance in P falciparum emerged along the Thailand–Myanmar border at least 8 years ago and has since increased substantially, with experts predicting resistance will reach rates reported in western Cambodia in 2–6 years.
Journal ArticleDOI
Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer.
Elizabeth Horak,N. Klenk,Russell Leek,Susan LeJeune,Kenneth G. C. Smith,N. Stuart,Adrian L. Harris,Michael Greenall,Kasia Stepniewska +8 more
TL;DR: The results suggest that angiogenesis is closely linked to metastasis, that it is acquired at a critical density of vessels, and that this process occurs as tumours enlarge or become more poorly differentiated.
Journal ArticleDOI
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial.
Arjen M. Dondorp,Caterina I. Fanello,Ilse C. E. Hendriksen,Ermelinda Gomes,Amir Seni,Kajal D. Chhaganlal,Kalifa Bojang,Rasaq Olaosebikan,Nkechinyere Anunobi,Kathryn Maitland,Esther Kivaya,Tsiri Agbenyega,Samuel Blay Nguah,Jennifer R Evans,Samwel Gesase,Catherine Kahabuka,George Mtove,Behzad Nadjm,Jacqueline L. Deen,Juliet Mwanga-Amumpaire,Margaret Nansumba,Corine Karema,Noella Umulisa,Aline Uwimana,Olugbenga A. Mokuolu,Olanrewaju T. Adedoyin,W B Johnson,Antoinette Tshefu,Marie A. Onyamboko,Tharisara Sakulthaew,Wirichada Pan Ngum,Kamolrat Silamut,Kasia Stepniewska,Charles J. Woodrow,D. Bethell,Bridget Wills,Martina Oneko,Tim E. A. Peto,Lorenz von Seidlein,Nicholas P. J. Day,Nicholas J. White +40 more
TL;DR: Parenteral artesunate should replace quinine as the treatment of choice for severe falciparum malaria worldwide, according to evidence from Asia, and substantially reduces mortality in African children with severe malaria.