K
Katrina Gwinn
Researcher at Baylor College of Medicine
Publications - 26
Citations - 3509
Katrina Gwinn is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Parkinsonism & Parkinson's disease. The author has an hindex of 15, co-authored 26 publications receiving 3222 citations. Previous affiliations of Katrina Gwinn include Mayo Clinic.
Papers
More filters
Journal ArticleDOI
Genome-wide association study reveals genetic risk underlying Parkinson's disease
Javier Simón-Sánchez,Claudia Schulte,Jose Bras,Jose Bras,Manu Sharma,J. Raphael Gibbs,J. Raphael Gibbs,Daniela Berg,Coro Paisán-Ruiz,Peter Lichtner,Sonja W. Scholz,Sonja W. Scholz,Dena G. Hernandez,Dena G. Hernandez,Rejko Krüger,Monica Federoff,Christine Klein,Alison Goate,Joel S. Perlmutter,Michael Bonin,Mike A. Nalls,Thomas Illig,Christian Gieger,Henry Houlden,Michael Steffens,Michael S. Okun,Brad A. Racette,Mark R. Cookson,Kelly D. Foote,Hubert H. Fernandez,Bryan J. Traynor,Stefan Schreiber,Sampath Arepalli,Ryan R. Zonozi,Katrina Gwinn,Marcel P. van der Brug,Marcel P. van der Brug,Grisel Lopez,Stephen J. Chanock,Arthur Schatzkin,Yikyung Park,Albert R. Hollenbeck,Jianjun Gao,Xuemei Huang,Nicholas W. Wood,Delia Lorenz,Günther Deuschl,Honglei Chen,Olaf Riess,John Hardy,Andrew B. Singleton,Thomas Gasser +51 more
TL;DR: It is demonstrated that an unequivocal role for common genetic variants in the etiology of typical PD and population-specific genetic heterogeneity in this disease is suggested, and supporting evidence that common variation around LRRK2 modulates risk for PD is provided.
Journal ArticleDOI
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
Michael J. Devine,Mina Ryten,Petr Vodicka,Alison J. Thomson,Tom Burdon,Henry Houlden,Fatima Cavaleri,Masumi Nagano,Masumi Nagano,Nicola J. Drummond,Jan-Willem Taanman,Anthony H.V. Schapira,Katrina Gwinn,John Hardy,Patrick A. Lewis,Tilo Kunath +15 more
TL;DR: This model represents a new experimental system to identify compounds that reduce levels of α- synuclein, and to investigate the mechanistic basis of neurodegeneration caused by α-synuclein dysfunction.
Journal ArticleDOI
A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1
Richard Crook,Auli Verkkoniemi,Jordi Pérez-Tur,Nitin D. Mehta,Matt Baker,Henry Houlden,Matthew J. Farrer,Mike Hutton,Sarah Lincoln,John Hardy,Katrina Gwinn,Mirja Somer,Anders Paetau,H Kalimo,H Kalimo,Raija Ylikoski,Minna Pöyhönen,Steve Kucera,Matti Haltia +18 more
TL;DR: A novel variant of Alzheimer's disease in a Finnish pedigree with 17 affected individuals of both sexes in three generations caused by a deletion of exon 9 (Δ9) of the presenilin 1 (PSI) gene from the mRNA was described.
Journal ArticleDOI
Parkinson's disease and α‐synuclein expression
TL;DR: The clinical impact of α‐synuclein locus multiplications, and the implications that this has for Parkinson's disease pathogenesis are outlined; potential strategies for disease‐modifying therapies for this currently incurable disorder are discussed.
Journal ArticleDOI
Low frequency of alpha-synuclein mutations in familial Parkinson's disease
Matthew J. Farrer,F Wavrant-De Vrieze,R Crook,L Boles,J Perez-Tur,J Hardy,William G. Johnson,J Steele,Demetrius M. Maraganore,Katrina Gwinn,Timothy Lynch +10 more
TL;DR: Primers and methods for exonic sequencing of this gene were developed and the entire coding region of the gene was sequenced and no genetic variation was found, suggesting that NACP is not the chromosome 4 locus for disease.