Shelly A. Trigg

TL;DR: The map uncovers significant interconnectivity between known and candidate cancer gene products, providing unbiased evidence for an expanded functional cancer landscape, while demonstrating how high-quality interactome models will help "connect the dots" of the genomic revolution.

TL;DR: This work cloned full-length open reading frames of alternatively spliced transcripts for a large number of human genes and used protein-protein interaction profiling to functionally compare hundreds of protein isoform pairs, revealing a widespread expansion of protein interaction capabilities through alternative splicing and suggesting that many alternative "isoforms" are functionally divergent (i.e., "functional alloforms").

TL;DR: A new interactome mapping approach is introduced by experimentally identifying interactions between brain-expressed alternatively spliced variants of ASD risk factors, demonstrating the critical role of spliceform networks for translating genetic knowledge into a better understanding of human diseases.

TL;DR: A massively multiplexed yeast two-hybrid method, CrY2H-seq, which uses a Cre recombinase interaction reporter to intracellularly fuse the coding sequences of two interacting proteins and next-generation DNA sequencing to identify these interactions en masse, is presented.

TL;DR: In this article, a PIF-INO80 regulatory module that is an intermediate step for allowing plants to change their growth trajectory in response to environmental changes was described. But the authors did not consider the effect of light on the DNA-binding properties of PIF7 and its impact on chromatin dynamics genome wide.