L
Linda Liliana Muñoz-Hernandez
Researcher at Monterrey Institute of Technology and Higher Education
Publications - 9
Citations - 642
Linda Liliana Muñoz-Hernandez is an academic researcher from Monterrey Institute of Technology and Higher Education. The author has contributed to research in topics: Genome-wide association study & Adipose tissue. The author has an hindex of 5, co-authored 9 publications receiving 547 citations. Previous affiliations of Linda Liliana Muñoz-Hernandez include Universidad Autónoma Metropolitana.
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Journal ArticleDOI
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico
A. L. Williams Amy,A. L. Williams Amy,S. B R Jacobs Suzanne,Hortensia Moreno-Macías,Alicia Huerta-Chagoya,Claire Churchhouse,Carla Marquez-Luna,María José Gómez-Vázquez,N. P. Burtt Noël,Carlos A. Aguilar-Salinas,Clicerio Gonzalez-Villalpando,Jose C. Florez,Jose C. Florez,Lorena Orozco,Teresa Tusié-Luna,David Altshuler,David Altshuler,David Altshuler,Stephan Ripke,Stephan Ripke,Alisa K. Manning,Humberto García-Ortiz,Benjamin M. Neale,Benjamin M. Neale,David Reich,David Reich,Daniel O. Stram,Juan Carlos Fernández-López,Sandra Romero-Hidalgo,Nick Patterson,Christopher A. Haiman,Irma Aguilar-Delfín,Angélica Martínez-Hernández,Federico Centeno-Cruz,Elvia Mendoza-Caamal,Cristina Revilla-Monsalve,Sergio Islas-Andrade,Emilio J. Cordova,Eunice Rodríguez-Arellano,Xavier Soberón,J. C. Florez Jose,J. C. Florez Jose,M. A. González-Villalpando María Elena,Brian E. Henderson,Kristine R. Monroe,Lynne R. Wilkens,Laurence N. Kolonel,Loic Le Marchand,Laura Riba,M. A. Ordóñez-Sánchez María Luisa,Rosario Rodríguez-Guillén,Ivette Cruz-Bautista,Maribel Rodríguez-Torres,Linda Liliana Muñoz-Hernandez,Tamara Sáenz,Donají Gómez,Ulices Alvirde,Robert C. Onofrio,Wendy Brodeur,Diane Gage,Jacquelyn Murphy,Jennifer Franklin,Scott Mahan,Kristin G. Ardlie,Andrew Crenshaw,Wendy Winckler,Kay Prüfer,Michael V. Shunkov,Susanna Sawyer,Udo Stenzel,Janet Kelso,Monkol Lek,Monkol Lek,Sriram Sankararaman,Sriram Sankararaman,Daniel G. MacArthur,Daniel G. MacArthur,A.P. Derevianko,Svante Pääbo,Suzanne B.R. Jacobs,Shuba Gopal,James A. Grammatikos,Ian Smith,Kevin Bullock,Amy Deik,Amanda Souza,Kerry A. Pierce,Clary B. Clish,Timothy Fennell,Yossi Farjoun,Stacey Gabriel,Myron D. Gross,Mark A. Pereira,Mark Seielstad,Woon-Puay Koh,E. Shyong Tai,Jason Flannick,Jason Flannick,Pierre Fontanillas,Andrew D. Morris,Tanya M. Teslovich,Gil Atzmon,John Blangero,Donald W. Bowden,John C. Chambers,John C. Chambers,Yoon Shin Cho,Ravindranath Duggirala,Benjamin Glaser,Benjamin Glaser,Craig L. Hanis,Jaspal S. Kooner,Jaspal S. Kooner,Markku Laakso,Jong-Young Lee,Yik Ying Teo,Yik Ying Teo,James G. Wilson,Sobha Puppala,Vidya S. Farook,Farook Thameem,Hanna E. Abboud,Ralph A. DeFronzo,Christopher P. Jenkinson,Donna M. Lehman,Joanne E. Curran,Maria L. Cortes,C. González-Villalpando Clicerio,L. Orozco Lorena +128 more
TL;DR: Analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism and an archaic genome sequence indicated that the risk haplotype introgressed into modern humans via admixture with Neanderthals.
Journal ArticleDOI
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci
Daphna Weissglas-Volkov,Carlos A. Aguilar-Salinas,Elina Nikkola,Kerry A. Deere,Ivette Cruz-Bautista,Olimpia Arellano-Campos,Linda Liliana Muñoz-Hernandez,Lizeth Gómez-Munguía,María Luisa Ordóñez-Sánchez,Prasad M. V. Linga Reddy,Aldons J. Lusis,Niina Matikainen,Marja-Riitta Taskinen,Laura Riba,Rita M. Cantor,Janet S. Sinsheimer,Teresa Tusié-Luna,P. Pajukanta +17 more
TL;DR: This first Mexican GWA study of lipids identified a novel GWA locus for high TG levels; used the interpopulation heterogeneity to significantly restrict three previously known European GWA signals; and surveyed whether the European lipid GWA SNPs extend to the Mexican population.
Journal ArticleDOI
Genome-wide association study of colorectal cancer in Hispanics
Stephanie L. Schmit,Fredrick R. Schumacher,Christopher K. Edlund,David V. Conti,Ugonna Ihenacho,Peggy Wan,David Van Den Berg,Graham Casey,Barbara K. Fortini,Heinz-Josef Lenz,Teresa Tusié-Luna,Carlos A. Aguilar-Salinas,Hortensia Moreno-Macías,Alicia Huerta-Chagoya,María Luisa Ordóñez-Sánchez,Rosario Rodríguez-Guillén,Ivette Cruz-Bautista,Maribel Rodríguez-Torres,Linda Liliana Muñoz-Hernandez,Olimpia Arellano-Campos,Donají Gómez,Ulices Alvirde,Clicerio González-Villalpando,María Elena González-Villalpando,Loic Le Marchand,Christopher A. Haiman,Jane C. Figueiredo +26 more
TL;DR: The results demonstrate the broad replication of known susceptibility regions and the importance of fine-mapping in ethnic minority populations in Hispanics and Latinos.
Journal ArticleDOI
The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance
Zong Miao,Marcus Alvarez,Arthur Ko,Yash V. Bhagat,Elior Rahmani,Brandon Jew,Sini Heinonen,Linda Liliana Muñoz-Hernandez,Miguel Herrera-Hernandez,Carlos A. Aguilar-Salinas,Teresa Tusié-Luna,Karen L. Mohlke,Markku Laakso,Kirsi H. Pietiläinen,Kirsi H. Pietiläinen,Eran Halperin,Päivi Pajukanta +16 more
TL;DR: It is demonstrated that obesity is a strong determinant of both prediabetes and insulin resistance, and it is discovered that individuals’ adipose cell-type composition, adipose MT gene expression, and body fat percent predict their insulin Resistance, emphasizing the critical role of adipose tissue in systemic insulin resistance.
Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms
Victor Rusu,Eitan Hoch,Josep M. Mercader,Danielle Tenen,Melissa Gymrek,Christina R. Hartigan,Michael DeRan,Marcin von Grotthuss,Pierre Fontanillas,Alexandra Spooner,Gaelen Guzman,Amy Deik,Kerry A. Pierce,Courtney Dennis,Clary B. Clish,Steven A. Carr,Bridget K. Wagner,Monica Schenone,Maggie C.Y. Ng,Brian H. Chen,Federico Centeno-Cruz,Carlos Zerrweck,Lorena Orozco,David M. Altshuler,Stuart L. Schreiber,Jose C. Florez,Suzanne B.R. Jacobs,Eric S. Lander,Daniel Shriner,Jiang Li,Wei-Min Chen,Xiuqing Guo,Jiankang Liu,Suzette J. Bielinski,Lisa R. Yanek,Mike A. Nalls,Mary E. Comeau,Laura J. Rasmussen-Torvik,Richard A. Jensen,Daniel S. Evans,Yan V. Sun,Ping An,Sanjay R. Patel,Yingchang Lu,Jirong Long,Loren L. Armstrong,Lynne E. Wagenknecht,Lingyao Yang,Beverly M. Snively,Nicholette D. Palmer,Poorva Mudgal,Carl D. Langefeld,Keith L. Keene,Barry I. Freedman,Josyf C. Mychaleckyj,Uma Nayak,Leslie J. Raffel,Mark O. Goodarzi,Y. D.I. Chen,Herman A. Taylor,Adolfo Correa,Mario Sims,David Couper,James S. Pankow,Eric Boerwinkle,Adebowale Adeyemo,Ayo P. Doumatey,Guanjie Chen,Rasika A. Mathias,Dhananjay Vaidya,Andrew B. Singleton,Alan B. Zonderman,Robert P. Igo,John R. Sedor,Edmond K. Kabagambe,David S. Siscovick,Barbara McKnight,Kenneth Rice,Yongmei Liu,Wen-Chi Hsueh,Wei Zhao,Lawrence F. Bielak,Aldi T. Kraja,Michael A. Province,Erwin P. Bottinger,Omri Gottesman,Qiuyin Cai,Wei Zheng,William J. Blot,William L. Lowe,Jennifer A. Pacheco,Dana C. Crawford,Elin Grundberg,Stephen S. Rich,M. Geoffrey Hayes,Xiao-Ou Shu,Ruth J. F. Loos,Ingrid B. Borecki,Patricia A. Peyser,Steven R. Cummings,Bruce M. Psaty,Myriam Fornage,Sudha K. Iyengar,Michele K. Evans,Diane M. Becker,W. H. Linda Kao,James G. Wilson,Jerome I. Rotter,Michèle M. Sale,Simin Liu,Charles N. Rotimi,Donald W. Bowden,Alicia Huerta-Chagoya,Humberto García-Ortiz,Hortensia Moreno-Macías,Alisa K. Manning,Lizz Caulkins,Noël P. Burtt,Jason Flannick,Nick Patterson,Carlos A. Aguilar-Salinas,Teresa Tusié-Luna,David Altshuler,Angélica Martínez-Hernández,Francisco Barajas-Olmos,Cecilia Contreras-Cubas,Elvia Mendoza-Caamal,Cristina Revilla-Monsalve,Sergio Islas-Andrade,Emilio J. Cordova,Xavier Soberón,Clicerio González-Villalpando,María Elena González-Villalpando,Christopher A. Haiman,Lynne R. Wilkens,Loic Le Marchand,Kristine R. Monroe,Laurence N. Kolonel,Olimpia Arellano-Campos,María Luisa Ordóñez-Sánchez,Maribel Rodríguez-Torres,Yayoi Segura-Kato,Rosario Rodríguez-Guillén,Ivette Cruz-Bautista,Linda Liliana Muñoz-Hernandez,Tamara Sáenz,Donají Gómez,Ulices Alvirde,Paloma Almeda-Valdes,Maria L. Cortes +149 more