The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens
Eric Duchaud,Christophe Rusniok,Lionel Frangeul,Carmen Buchrieser,Alain Givaudan,Sead Taourit,Stéphanie Bocs,Caroline Boursaux-Eude,Michael Chandler,Jean-François Charles,Elie Dassa,Richard Derose,Sylviane Derzelle,Georges Freyssinet,Sophie Gaudriault,Claudine Médigue,Anne Lanois,Kerrie Powell,Patricia Siguier,Rachel Vincent,Vincent Paul Mary Wingate,Mohamed Zouine,Philippe Glaser,Noël Boemare,Antoine Danchin,Frank Kunst +25 more
TLDR
Compared with the genomes of related bacteria, the complete genome sequence of strain TT01 reveals the acquisition of virulence factors by extensive horizontal transfer and provides clues about the evolution of an insect pathogen.Abstract:
Photorhabdus luminescens is a symbiont of nematodes and a broad-spectrum insect pathogen. The complete genome sequence of strain TT01 is 5,688,987 base pairs (bp) long and contains 4,839 predicted protein-coding genes. Strikingly, it encodes a large number of adhesins, toxins, hemolysins, proteases and lipases, and contains a wide array of antibiotic synthesizing genes. These proteins are likely to play a role in the elimination of competitors, host colonization, invasion and bioconversion of the insect cadaver, making P. luminescens a promising model for the study of symbiosis and host-pathogen interactions. Comparison with the genomes of related bacteria reveals the acquisition of virulence factors by extensive horizontal transfer and provides clues about the evolution of an insect pathogen. Moreover, newly identified insecticidal proteins may be effective alternatives for the control of insect pests.read more
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Genomic islands in pathogenic and environmental microorganisms
TL;DR: Recent lessons that have been learned from pathogenicity islands in pathogenic microorganisms are discussed and how they apply to the role of genomic islands in commensal, symbiotic and environmental bacteria are discussed.
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Insect pathogens as biological control agents: Back to the future.
Lawrence A. Lacey,David Grzywacz,David I. Shapiro-Ilan,Roger Frutos,M. Brownbridge,Mark S. Goettel +5 more
TL;DR: Current information on development, use and future directions of insect-specific viruses, bacteria, fungi and nematodes as components of integrated pest management strategies for control of arthropod pests of crops, forests, urban habitats, and insects of medical and veterinary importance is presented.
Journal ArticleDOI
Diversity and natural functions of antibiotics produced by beneficial and plant pathogenic bacteria.
Jos M. Raaijmakers,Mark Mazzola +1 more
TL;DR: The innate functions of antibiotics to producing bacteria in their native ecosystem are just beginning to emerge, but current knowledge already reveals a breadth of activities well beyond the historical perspective of antibiotics as weaponry in microbial conflicts.
Journal ArticleDOI
RTX proteins: a highly diverse family secreted by a common mechanism.
Irena Linhartova,Ladislav Bumba,Jiří Mašín,Marek Basler,Radim Osicka,Jana Kamanova,Kateřina Procházková,Irena Adkins,Jana Hejnová-Holubová,Lenka Sadilkova,Jana Morova,Peter Sebo +11 more
TL;DR: This review summarizes the current state of knowledge on the organization of rtx loci and on the biological and biochemical activities of therein encoded proteins and discusses the so far characterized RTX family members.
Journal ArticleDOI
Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways.
Nicholas R. Thomson,Debra J. Clayton,Daniel Windhorst,Georgios S. Vernikos,Susanne Davidson,Carol Churcher,Michael A. Quail,Mark P. Stevens,Michael Jones,Michael Watson,Andy Barron,Abigail N. Layton,Derek Pickard,Robert A. Kingsley,Alex Bignell,Louise Clark,Barbara Harris,Doug Ormond,Zahra Abdellah,Karen Brooks,Inna Cherevach,Tracey Chillingworth,John Woodward,Halina Norberczak,Angela Lord,Claire Arrowsmith,Kay Jagels,Sharon Moule,Karen Mungall,Mandy Sanders,Sally Whitehead,José A. Chabalgoity,Duncan J. Maskell,Tom J. Humphrey,Mark Roberts,Paul A. Barrow,Gordon Dougan,Julian Parkhill +37 more
TL;DR: Genome comparisons between these and other Salmonella isolates indicate that S. Gallinarum 287/91 is a recently evolved descendent of S. Enteritidis, and it is proposed that experimental analysis in chickens and mice could provide an experimentally tractable route toward unraveling the genetic basis of host adaptation in S. enterica.
References
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