Journal ArticleDOI
Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17–secreting T cells
Mathilde Dusseaux,Mathilde Dusseaux,Emmanuel Martin,Emmanuel Martin,Nacer Serriari,Isabelle Peguillet,Virginie Premel,Virginie Premel,Delphine Louis,Maud Milder,Lionel Le Bourhis,Lionel Le Bourhis,Claire Soudais,Claire Soudais,Emmanuel Treiner,Olivier Lantz,Olivier Lantz +16 more
TLDR
The gut-liver homing characteristics, high expression of ABCB1, and ability to secrete interleukin-17 probably participate in the antibacterial properties of MAIT cells.About:
This article is published in Blood.The article was published on 2011-01-27. It has received 815 citations till now. The article focuses on the topics: Cytotoxic T cell & Mucosal associated invariant T cell.read more
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A human memory T cell subset with stem cell-like properties
Luca Gattinoni,Enrico Lugli,Yun Ji,Zoltan Pos,Chrystal M. Paulos,Máire F. Quigley,Máire F. Quigley,Jorge R. Almeida,Emma Gostick,Zhiya Yu,Carmine Carpenito,Ena Wang,Daniel C. Douek,David Price,David Price,Carl H. June,Francesco M. Marincola,Mario Roederer,Nicholas P. Restifo +18 more
TL;DR: A long-lived human memory T cell population that has an enhanced capacity for self-renewal and a multipotent ability to derive central memory, effector memory and effector T cells is described.
Journal ArticleDOI
Regional specialization within the intestinal immune system
TL;DR: The anatomical and physiological distinctions that are observed in the small and large intestines are detailed, and it is suggested how these may account for the diversity in the immune apparatus that is seen throughout the intestine.
Journal ArticleDOI
Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations.
Sonya A. MacParland,Sonya A. MacParland,Jeff C. Liu,Xue Zhong Ma,Brendan T. Innes,Agata Bartczak,Blair K. Gage,Justin Manuel,Nicholas Khuu,Juan Echeverri,Ivan Linares,Rahul Gupta,Michael L Cheng,Lewis Y. Liu,Damra Camat,Sai W. Chung,Rebecca K. Seliga,Zigong Shao,Elizabeth Lee,Shinichiro Ogawa,Mina Ogawa,Michael D. Wilson,Jason E. Fish,Jason E. Fish,Markus Selzner,Anand Ghanekar,David R. Grant,Paul D. Greig,Gonzalo Sapisochin,Nazia Selzner,Neil Winegarden,Oyedele Adeyi,Oyedele Adeyi,Oyedele Adeyi,Gordon Keller,Gordon Keller,Gordon Keller,Gary D. Bader,Ian D. McGilvray +38 more
TL;DR: A map of the cellular landscape of the human liver using single-cell RNA sequencing is reported, and distinct populations of intrahepatic macrophages that may play specific roles in liver disease are identified.
Journal ArticleDOI
Commensal bacteria at the interface of host metabolism and the immune system
Jonathan R. Brestoff,David Artis +1 more
TL;DR: The current knowledge of how commensal bacteria regulate the production and bioavailability of immunomodulatory, diet-dependent nutrients and metabolites is reviewed and how these commensAL bacteria–derived products may regulate the development and function of the mammalian immune system is discussed.
Journal ArticleDOI
Liver inflammation and fibrosis
Yukinori Koyama,David A. Brenner +1 more
TL;DR: The initiation of inflammation in the liver, the liver inflammatory cells, and their crosstalk with myofibroblasts are reviewed.
References
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Journal ArticleDOI
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Reinhold Förster,Andreas Schubel,Dagmar Breitfeld,Elisabeth Kremmer,Ingrid Renner-Müller,Eckhard Wolf,Martin Lipp +6 more
TL;DR: In this paper, the chemokine receptor CCR7 was identified as an important organizer of the primary immune response in mice, and severely delayed kinetics regarding the antibody response and lack contact sensitivity and delayed type hypersensitivity reactions.
Journal ArticleDOI
Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells
Dörte Hamann,Paul A. Baars,M.H.G. Rep,Berend Hooibrink,Susana R. Kerkhof-Garde,Michèl R. Klein,René A. W. van Lier +6 more
TL;DR: In this article, two discrete primed subpopulations are found within the circulating human CD8+ T cell subset, i.e., CD45RA−CD45R0+ cells and CD27−CD27− cells.
Journal ArticleDOI
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
Emmanuel Treiner,Livine Duban,Seiamak Bahram,Mirjana Radosavljevic,Valérie Wanner,Florence Tilloy,Pierre Affaticati,Susan Gilfillan,Olivier Lantz +8 more
TL;DR: It is shown that T cells that express the canonical hVα7.2-Jα33 or mVα19-J α33 TCR rearrangement are preferentially located in the gut lamina propria of humans and mice, respectively, and are therefore genuine mucosal-associated invariant T (MAIT) cells.
Journal ArticleDOI
Antimicrobial activity of mucosal-associated invariant T cells
Lionel Le Bourhis,Emmanuel Martin,Emmanuel Martin,Isabelle Peguillet,Isabelle Peguillet,Amélie Guihot,Nathalie Froux,Maxime Coré,Maxime Coré,Eva Lévy,Eva Lévy,Mathilde Dusseaux,Mathilde Dusseaux,Vanina Meyssonnier,Virginie Premel,Virginie Premel,Charlotte Ngo,Béatrice Riteau,Livine Duban,Livine Duban,Delphine Robert,Delphine Robert,Shouxiong Huang,Martin Rottman,Claire Soudais,Claire Soudais,Olivier Lantz,Olivier Lantz,Olivier Lantz +28 more
TL;DR: MAIT cells are evolutionarily conserved innate-like lymphocytes that sense and help fight off microbial infection and protect against infection by Mycobacterium abscessus or Escherichia coli.
Journal ArticleDOI
Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.
Lorenzo Cosmi,Raffaele De Palma,Veronica Santarlasci,Laura Maggi,Manuela Capone,Francesca Frosali,Gabriella Rodolico,Valentina Querci,Gianfranco Abbate,Roberta Angeli,Liberato Berrino,Massimiliano Fambrini,Marzia Caproni,Francesco Tonelli,Elena Lazzeri,Paola Parronchi,Francesco Liotta,Enrico Maggi,Sergio Romagnani,Francesco Annunziato +19 more
TL;DR: It is shown that all IL-17–producing cells originate from CD161+ naive CD4+ T cells of umbilical cord blood, as well as of the postnatal thymus, in response to the combined activity of IL-1β and IL-23.
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Marielle C. Gold,Marielle C. Gold,Stefania Cerri,Susan Smyk-Pearson,Meghan E. Cansler,Todd M. Vogt,Jacob Delepine,Jacob Delepine,Ervina Winata,Gwendolyn Swarbrick,Gwendolyn Swarbrick,Wei Jen Chua,Yik Y. L. Yu,Olivier Lantz,Matthew S. Cook,Megan D. Null,David B. Jacoby,Melanie J. Harriff,Melanie J. Harriff,Deborah A. Lewinsohn,Ted H. Hansen,David M. Lewinsohn,David M. Lewinsohn +22 more