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Maggi Pack

Researcher at Rockefeller University

Publications -  20
Citations -  5017

Maggi Pack is an academic researcher from Rockefeller University. The author has contributed to research in topics: Dendritic cell & Immune system. The author has an hindex of 18, co-authored 20 publications receiving 4263 citations.

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Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.

TL;DR: In this paper, the capacity of Dendritic cells to interact with NK cells in human lymphoid organs and identify the role of specific DC-derived cytokines was identified. And they demonstrated that DCs colocalize with NKs in the T cell areas of lymph nodes.
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Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209+ dendritic cells for immune T cell areas

TL;DR: It is shown that fully differentiated monocyte-derived DCs (Mo-DCs) develop in mice and DC-SIGN/CD209a marks the cells, and the blood monocyte reservoir becomes the dominant presenting cell in response to select microbes, yielding DC- SIGN(+) cells with critical functions of DCs.
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The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen

TL;DR: It is found that encapsulated Streptococcus pneumoniae are rapidly cleared by these macrophages from the bloodstream, and that capture also takes place when different cell lines express SIGN-R1 after transfection.