M
Mark P. Mattson
Researcher at Johns Hopkins University School of Medicine
Publications - 988
Citations - 151506
Mark P. Mattson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Glutamate receptor & Neuroprotection. The author has an hindex of 200, co-authored 980 publications receiving 138033 citations. Previous affiliations of Mark P. Mattson include University of Kentucky & National Institutes of Health.
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Ancient viral protein enrages astrocytes in multiple sclerosis
Mark P. Mattson,Dennis D. Taub +1 more
TL;DR: New work in this issue indicates that Syncytin is activated in multiple sclerosis astrocytes and microglia, contributing to the inflammation-induced myelin destruction that causes disease symptoms.
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Kainic acid-induced naip expression in the hippocampus is blocked in mice lacking TNF receptors.
TL;DR: It is reported that systemic administration of kainic acid rapidly elevates expression of mRNA encoding neuronal apoptosis inhibitor protein (NAIP) in the hippocampus and that this increase does not occur in mice that lack TNF receptors, suggesting that induction of the naip gene may contribute to the neuroprotective properties of TNF.
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In silico analysis of gene expression profiles in the olfactory mucosae of aging senescence-accelerated mice.
Thomas V. Getchell,Xuejun Peng,C. Paul Green,Arnold J. Stromberg,Kuey-Chu Chen,Mark P. Mattson,Marilyn L. Getchell +6 more
TL;DR: The rate constant α in the Gompertz equation on aging to intrinsic as opposed to environmental mechanisms of senescence based on the analysis of genes modulated during aging in the olfactory mucosa was related to the variability in the mean hybridization signals as determined by the two‐sided t‐test.
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Compartmentalization of signaling in neurons: evolution and deployment.
TL;DR: The purpose of this introductory article is to set the stage for the following articles by briefly reviewing fundamental aspects of the molecular and cellular biology of synapses in an evolutionary context.
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Insulating axons via NF-kappaB.
TL;DR: The transcription factor NF-κB, increasingly recognized as a key regulator of developmental and adult neural plasticity, is now reported to be essential for axon myelination as well.