M
Mark P. Mattson
Researcher at Johns Hopkins University School of Medicine
Publications - 988
Citations - 151506
Mark P. Mattson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Glutamate receptor & Neuroprotection. The author has an hindex of 200, co-authored 980 publications receiving 138033 citations. Previous affiliations of Mark P. Mattson include University of Kentucky & National Institutes of Health.
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Membrane properties of rat embryonic multipotent neural stem cells.
Jingli Cai,Aiwu Cheng,Yongquan Luo,Chengbiao Lu,Mark P. Mattson,Mahendra S. Rao,Katsutoshi Furukawa +6 more
TL;DR: The results show that fetal NSCs exhibit a unique signature that can be used to determine their location and assess their ability to respond to their environment.
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Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization.
TL;DR: It is shown that both embryonic and adult hippocampal neurons express leptin receptors coupled to activation of STAT3 and phosphatidylinositol 3-kinase-Akt signaling pathways, suggesting that leptin signaling serves a neurotrophic function in the developing and adult hippocampus
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Activity-Induced Notch Signaling in Neurons Requires Arc/Arg3.1 and Is Essential for Synaptic Plasticity in Hippocampal Networks
Lavinia Alberi,Shuxi Liu,Yue Wang,Ramy Badie,Constance Smith-Hicks,Jing Wu,Tarran J. Pierfelice,Bagrat Abazyan,Mark P. Mattson,Mark P. Mattson,Dietmar Kuhl,Mikhail V. Pletnikov,Paul F. Worley,Nicholas Gaiano +13 more
TL;DR: Notch1 and its ligand Jagged1 are present at the synapse, and that Notch signaling in neurons occurs in response to synaptic activity, and neuronal NotCh signaling is positively regulated by Arc/Arg3.1, an activity-induced gene required for synaptic plasticity.
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Circulating Brain-Derived Neurotrophic Factor and Indices of Metabolic and Cardiovascular Health: Data from the Baltimore Longitudinal Study of Aging
Erin Golden,Ana B F Emiliano,Stuart Maudsley,B. Gwen Windham,Olga D. Carlson,Josephine M. Egan,Ira Driscoll,Luigi Ferrucci,Bronwen Martin,Mark P. Mattson +9 more
TL;DR: Plasma BDNF significantly correlates with multiple risk factors for metabolic syndrome and cardiovascular dysfunction, whether BDNF contributes to the pathogenesis of these disorders or functions in adaptive responses to cellular stress (as occurs in the brain).
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Secreted form of β-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices.
TL;DR: It is reported that sAPP α shifts the frequency dependence for induction of long-term depression of synaptic transmission (LTD) in hippocampal slices from adult rats, and pretreatment of slices with 8-bromo-cyclic GMP mimicked the effect of sAPPα on LTD suggesting a role for cyclicGMP in modulation of LTD.