Mark P. Mattson

TL;DR: It is found that TREM2 deficiency impaired microglia phagocytic clearance of pathological TDP-43, and enhanced neuronal damage and motor function impairments, and TAR-DNA binding protein 43 kDa (TDP- 43)-related neurodegenerative disease via viral-mediated expression of human TDP -43 protein in mice or inducible expression of hTDP43 with defective nuclear localization signals in transgenic mice.

TL;DR: It is found that while the amounts of Shh transcript and protein in rat brains are nearly undetectable at birth, they increase continuously during postnatal development and remain at readily detectable levels in young adults.

TL;DR: It is reported that telomerase activity and expression of TERT are induced in the hippocampus of adult mice after administration of the seizure-inducing excitotoxin kainate, and the first evidence that TERT can be expressed in microglia is shown, suggesting roles for telomersase in micro glial responses to brain injury.

TL;DR: Roles for homocysteine and folate deficiency in the white matter damage in AD and related neurodegenerative disorders are suggested.

TL;DR: The results indicate that FABP5 mRNA knockdown results in the accumulation of cellular triglycerides, decreased cholesterol levels, and reduced secretion of apoB100 protein and lipoprotein-like particles, suggesting that F ABP5 plays a critical role in lipid metabolism in RPE cells, suggesting the downregulation in the RPE/choroid complex in vivo might contribute to aging and early age-related macular degeneration.