M
Mark P. Mattson
Researcher at Johns Hopkins University School of Medicine
Publications - 988
Citations - 151506
Mark P. Mattson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Glutamate receptor & Neuroprotection. The author has an hindex of 200, co-authored 980 publications receiving 138033 citations. Previous affiliations of Mark P. Mattson include University of Kentucky & National Institutes of Health.
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NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis
Bin Cheng,Mark P. Mattson +1 more
TL;DR: Findings indicate that growth factors can stabilize neuronal calcium homeostasis in central neurons and thereby protect them against environmental insults.
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The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies.
TL;DR: The present review summarizes the neuroprotective effects of calorie restriction, of the ketogenic diet and of ketone bodies, and compares their putative mechanisms of action.
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Curcumin requires tumor necrosis factor α signaling to alleviate cognitive impairment elicited by lipopolysaccharide.
TL;DR: Evidence is provided that curcumin ameliorates cognitive deficits associated with activation of the innate immune response by mechanisms requiring functional tumor necrosis factor α receptor 2 (TNFR2) signaling, and the possibility that therapeutic approaches against cognitive decline designed to selectively enhance TNFR2 signaling are likely to be more beneficial than the use of anti-inflammatory drugs per se is suggested.
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Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.
Qing Guo,Weiming Fu,Bryce L. Sopher,Miles W. Miller,Carol B. Ware,George M. Martin,Mark P. Mattson +6 more
TL;DR: A direct link between a genetic defect that causes AD and excitotoxic neuronal degeneration is established, and new avenues for therapeutic intervention in AD patients are indicated.
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Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease.
Veerendra Kumar Madala Halagappa,Zhihong Guo,Michelle Pearson,Yasuji Matsuoka,Roy G. Cutler,Frank M. LaFerla,Mark P. Mattson +6 more
TL;DR: CR and IF dietary regimens can ameliorate age-related deficits in cognitive function by mechanisms that may or may not be related to Abeta and tau pathologies.