M
Mark P. Mattson
Researcher at Johns Hopkins University School of Medicine
Publications - 988
Citations - 151506
Mark P. Mattson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Glutamate receptor & Neuroprotection. The author has an hindex of 200, co-authored 980 publications receiving 138033 citations. Previous affiliations of Mark P. Mattson include University of Kentucky & National Institutes of Health.
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Journal ArticleDOI
The Therapeutic Potential of microRNAs in Nervous System Damage, Degeneration, and Repair
TL;DR: MicroRNAS have been shown to control cellular proliferation and specification, suggesting that manipulation of miRNAs in cultured cells could result in more convenient generation of pure cell populations for transplantation and the potential for improved diagnostic tools.
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SDF1α/CXCR4 signaling stimulates β-catenin transcriptional activity in rat neural progenitors
Yongquan Luo,Jingli Cai,Haipeng Xue,Mark P. Mattson,Mark P. Mattson,Mahendra S. Rao,Mahendra S. Rao +6 more
TL;DR: It is reported that SDF1α/CXCR4 signaling activates β-catenin/TCF transcriptional activity in embryonic rat spinal cord neural progenitors and the data suggest that Sdf1α-induced β-Catenin stabilization effect was inhibited by pretreatment of the cells with either pertussis toxin (PTX), an inactivator of G protein-coupled receptors, or PD98059, a MEK1 inhibitor.
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Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levels
Alexis M. Stranahan,Kim Lee,Paul J. Pistell,Paul J. Pistell,Christopher M. Nelson,Nathaniel Readal,Marshall G. Miller,Edward L. Spangler,Donald K. Ingram,Donald K. Ingram,Mark P. Mattson +10 more
TL;DR: Preventing the increases in corticosterone levels that accompanies the onset of experimental diabetes also prevented deficits in complex maze learning, suggesting that the cognitive profiles of diabetic and aged rats share common features.
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Interferon-γ is up-regulated in the hippocampus in response to intermittent fasting and protects hippocampal neurons against excitotoxicity
TL;DR: Data show that intermittent fasting DR stimulates IFN‐γ‐mediated neuroprotective signaling in the hippocampus, suggesting a role for this cytokine in the previously reported ability of DR to protect neurons in animal models of severe epileptic seizures, stroke, and neurodegenerative disorders.
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Dose response biology: The case of resveratrol
TL;DR: Recognition of the widespread occurrence of the hormetic nature of many of the responses of resveratrol is important to help optimize study design protocols by investigators, create a dose-response framework for better addressing dose-related biological complexities and assist in the development of public health and medical guidance.