M
Mark P. Mattson
Researcher at Johns Hopkins University School of Medicine
Publications - 988
Citations - 151506
Mark P. Mattson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Glutamate receptor & Neuroprotection. The author has an hindex of 200, co-authored 980 publications receiving 138033 citations. Previous affiliations of Mark P. Mattson include University of Kentucky & National Institutes of Health.
Papers
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Journal ArticleDOI
Purine Biosynthesis Enzymes in Hippocampal Neurons
TL;DR: Using immunoblotting and high-resolution light and electron microscopic analysis, it is found that all three purine biosynthesis enzymes are broadly distributed in hippocampal neurons with pools of these enzymes associated with mitochondria.
Book ChapterDOI
Transcriptional Mediators of Cellular Hormesis
TL;DR: The periodic pulsatile activation of Nrf2, NF-κB, HSF, and FOXO has been found to be essential to obtaining the beneficial effects of various hormetic stimuli in different biological models and this chapter discusses molecular mechanisms and gene targets for these transcription factor families in the hormetic adaptive context.
Journal ArticleDOI
Hold the Salt: Vasopressor Role for BDNF
TL;DR: It is demonstrated that brain-derived neurotrophic factor signaling mediates salt-induced blood pressure elevation by increasing the excitability of hypothalamic vasopressin-secreting neurons.
Journal ArticleDOI
Impact of Dietary Restriction on Brain Aging and Neurodegenerative Disorders: Emerging Findings from Experimental and Epidemiological Studies
Journal ArticleDOI
Phosphothioated oligodeoxynucleotides induce nonspecific effects on neuronal cell adhesion in a growth substrate-dependent manner.
Eitan Okun,Mark P. Mattson +1 more
TL;DR: It is found that PTO‐ODN aimed at activating TLR9 induces a non‐TLR9‐specific detachment phenotype in cortical neurons plated on either laminin or PEI, but not on PLO, which suggests that the use of PTO•ODN can cause nonspecific effects on cell adhesion that could compromise interpretation of data from experiments using PTO-ODN.