M
Mark P. Mattson
Researcher at Johns Hopkins University School of Medicine
Publications - 988
Citations - 151506
Mark P. Mattson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Glutamate receptor & Neuroprotection. The author has an hindex of 200, co-authored 980 publications receiving 138033 citations. Previous affiliations of Mark P. Mattson include University of Kentucky & National Institutes of Health.
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Neurohormetic phytochemicals: An evolutionary-bioenergetic perspective.
TL;DR: Some of the signaling pathways relevant to cellular energy metabolism that are modulated by 'neurohormetic phytochemicals' (potentially toxic chemicals produced by plants that have beneficial effects on animals when consumed in moderate amounts) are described.
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Neurotrophin-4/5 protects hippocampal and cortical neurons against energy deprivation- and excitatory amino acid-induced injury.
TL;DR: It is found that NT-4/5 can protect cultured embryonic rat hippocampal and cortical neurons against glucose deprivation-induced injury and increases neuronal resistance to calcium-mediated injury, indicating that, as with other neurotrophins, it may serve a neuroprotective function in the brain.
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Enhancing and Extending Biological Performance and Resilience.
Rehana K. Leak,Edward J. Calabrese,Walter J. Kozumbo,Jeffrey M. Gidday,Thomas E. Johnson,James R. Mitchell,C. Keith Ozaki,Reinhard Wetzker,Aalt Bast,Regina G. Belz,Hans Erik Bøtker,Sebastian Koch,Mark P. Mattson,Roger P. Simon,Randy L. Jirtle,Melvin E. Andersen +15 more
TL;DR: A path forward is proposed for researchers hoping to optimize protocols that support human health and longevity, whether in civilians, soldiers, athletes, or the elderly patients, by recommending approaches to control and exploit endogenous defense mechanisms to enhance the structure and function of biological tissues.
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Evolutionarily conserved transcriptional co-expression guiding embryonic stem cell differentiation.
TL;DR: Through these studies, evolutionary conservation at genomic, transcriptomic, and network levels is shown to be an effective predictor of molecular factors and mechanisms controlling ESC development.
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Targeting TNF-α receptors for neurotherapeutics
Wayne Chadwick,Tim Magnus,Bronwen Martin,Aleksander Keselman,Mark P. Mattson,Stuart Maudsley +5 more
TL;DR: This research was supported by the Intramural Research Program of the NIH, National Institute on Aging and the authors have no conflicts of scientific interest with respect to the manuscript.