M
Mark P. Mattson
Researcher at Johns Hopkins University School of Medicine
Publications - 988
Citations - 151506
Mark P. Mattson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Glutamate receptor & Neuroprotection. The author has an hindex of 200, co-authored 980 publications receiving 138033 citations. Previous affiliations of Mark P. Mattson include University of Kentucky & National Institutes of Health.
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Journal ArticleDOI
Progress in the Development of Caloric Restriction Mimetic Dietary Supplements
Mark P. Mattson,Mark P. Mattson,Wenzhen Duan,Jaewon Lee,Zhihong Guo,George S. Roth,Donald K. Ingram,Mark A. Lane +7 more
TL;DR: The initial findings reviewed here suggest a novel approach for the investigation of basic mechanisms of aging, in which cells upregulate heat-shock and other chaperone proteins, and growth factors.
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Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults.
Elisa Mitiko Kawamoto,M. Gleichmann,L. M. Yshii,L. de Sá Lima,Mark P. Mattson,Cristoforo Scavone +5 more
TL;DR: It is suggested that Wnt signaling can protect neural cells against apoptosis induced by toxic agents, which is relevant to the pathogenesis of Alzheimer's and Huntington's diseases.
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Live longer sans the AT1A receptor.
Mark P. Mattson,Stuart Maudsley +1 more
TL;DR: AT(1A)R-deficient mice live longer and have lower levels of oxidative stress than wild-type mice (Benigni et al., 2009), suggesting a role for AT(1a)R signaling in the aging process.
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Combination Therapy with Low-Dose IVIG and a C1-esterase Inhibitor Ameliorates Brain Damage and Functional Deficits in Experimental Ischemic Stroke
Xinzhi Chen,Thiruma V. Arumugam,Yi-Lin Cheng,Jong Hwan Lee,Jong Hwan Lee,Srinivasulu Chigurupati,Mark P. Mattson,Mark P. Mattson,Milan Basta +8 more
TL;DR: It is demonstrated that intravenous immunoglobulin (IVIG), a scavenger of potentially harmful complement fragments, and C1-esterase inhibitor (C1-INH), an inhibitor of complement activation, exert a beneficial effect on the outcome of experimental brain ischemia and reperfusion injury induced by transient occlusion of middle cerebral artery in mice.
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Clathrin assembly proteins AP180 and CALM in the embryonic rat brain
TL;DR: The developmental stage of AP180 and CALM expression is identified and suggest that each protein has distinct functions in neural development, including those involved in embryonic development and postmitotic neurons.