M
Mark P. Mattson
Researcher at Johns Hopkins University School of Medicine
Publications - 988
Citations - 151506
Mark P. Mattson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Glutamate receptor & Neuroprotection. The author has an hindex of 200, co-authored 980 publications receiving 138033 citations. Previous affiliations of Mark P. Mattson include University of Kentucky & National Institutes of Health.
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Journal ArticleDOI
Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients.
Ward A. Pedersen,Weiming Fu,Jeffrey N. Keller,William R. Markesbery,Stanley H. Appel,R. Glenn Smith,Edward J. Kasarskis,Mark P. Mattson +7 more
TL;DR: Increased modification of proteins by 4‐hydroxynoneal (HNE), a product of membrane lipid peroxidation, in the lumbar spinal cord of sporadic amyotrophic lateral sclerosis patients versus that of neurologically normal controls is reported.
Journal ArticleDOI
Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity.
TL;DR: The modification of processes such as outgrowth of neurites and long-term potentiation of synaptic transmission by agents that suppress or promote MLP suggests roles for subtoxic levels of MLP in neuronal plasticity.
Journal ArticleDOI
Microglial Activation Resulting from CD40-CD40L Interaction After β-Amyloid Stimulation
Jun Tan,Terrence Town,Daniel Paris,Takashi Mori,Zhiming Suo,Fiona Crawford,Mark P. Mattson,Richard A. Flavell,Michael Mullan +8 more
TL;DR: CD40 expression was increased and abnormal tau phosphorylation was reduced in Tg APPsw animals deficient for CD40L, suggesting that the CD40-CD40L interaction is an early event in AD pathogenesis.
Journal ArticleDOI
Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
Stephen C. Cunnane,Eugenia Trushina,Cecilie Morland,Alessandro Prigione,Gemma Casadesus,Zane B. Andrews,M. Flint Beal,Linda H. Bergersen,Roberta Diaz Brinton,Suzanne M. de la Monte,Anne Eckert,Jenni Harvey,Ross Jeggo,Jack H. Jhamandas,Oliver Kann,Clotilde Mannoury la Cour,William Martin,Gilles Mithieux,Paula I. Moreira,Michael P. Murphy,Klaus-Armin Nave,Tal Nuriel,Stéphane H. R. Oliet,Stéphane H. R. Oliet,Frédéric Saudou,Frédéric Saudou,Mark P. Mattson,Russell H. Swerdlow,Millan Mark +28 more
TL;DR: The approaches described include restoring oxidative phosphorylation and glycolysis, increasing insulin sensitivity, correcting mitochondrial dysfunction, ketone-based interventions, acting via hormones that modulate cerebral energetics, RNA therapeutics and complementary multimodal lifestyle changes.
Journal ArticleDOI
NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
Evandro Fei Fang,Henok Kassahun,Deborah L. Croteau,Morten Scheibye-Knudsen,Morten Scheibye-Knudsen,Krisztina Marosi,Huiming Lu,Raghavendra A. Shamanna,Sumana Kalyanasundaram,Sumana Kalyanasundaram,Ravi Chand Bollineni,Mark A. Wilson,Wendy B. Iser,Bradley N. Wollman,Marya Morevati,Marya Morevati,Jun Li,Jesse S. Kerr,Qiping Lu,Tyler B. Waltz,Jane Tian,David A. Sinclair,David A. Sinclair,Mark P. Mattson,Mark P. Mattson,Hilde Nilsen,Vilhelm A. Bohr,Vilhelm A. Bohr +27 more
TL;DR: This work links two major theories on aging, DNA damage accumulation, and mitochondrial dysfunction through nuclear DNA damage-induced nuclear-mitochondrial signaling, and demonstrates that they are important pathophysiological determinants in premature aging of A-T, pointing to therapeutic interventions.