M
Mark P. Mattson
Researcher at Johns Hopkins University School of Medicine
Publications - 988
Citations - 151506
Mark P. Mattson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Glutamate receptor & Neuroprotection. The author has an hindex of 200, co-authored 980 publications receiving 138033 citations. Previous affiliations of Mark P. Mattson include University of Kentucky & National Institutes of Health.
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Intermittent metabolic switching, neuroplasticity and brain health
TL;DR: How intermittent metabolic switching, repeating cycles of a metabolic challenge that induces ketosis (fasting and/or exercise) followed by a recovery period (eating, resting and sleeping), may optimize brain function and resilience throughout the lifespan is considered, with a focus on the neuronal circuits involved in cognition and mood.
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Antiparallel β-sheet architecture in Iowa-mutant β-amyloid fibrils
TL;DR: The antiparallel D23N-Aβ1–40 fibril model represents a specific “toxic intermediate” in the aggregation process of a disease-associated Aβ mutant and reveals how both parallel and antipar parallel cross-β structures can be constructed from similar peptide monomer conformations and stabilized by similar sets of interactions, primarily hydrophobic in nature.
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A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.
Carsten Culmsee,Xiaoxiang Zhu,Qian Sheng Yu,Sic L. Chan,Simonetta Camandola,Zhihong Guo,Nigel H. Greig,Mark P. Mattson,Mark P. Mattson +8 more
TL;DR: Preclinical studies demonstrate the efficacy of a p53 inhibitor in models of stroke and neurodegenerative disorders, and suggest that drugs that inhibit p53 may reduce the extent of brain damage in related human neurodegenersative conditions.
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Mitochondria and neuroplasticity
TL;DR: Emerging data suggesting that mitochondria emit molecular signals that can act locally or travel to distant targets including the nucleus may play roles in impaired neuroplasticity and neuronal degeneration in Alzheimer's disease, Parkinson's Disease, psychiatric disorders and stroke.
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Curcumin Stimulates Proliferation of Embryonic Neural Progenitor Cells and Neurogenesis in the Adult Hippocampus
So Jung Kim,Tae Gen Son,Hee Ra Park,Mi-Kyung Park,Min-Sun Kim,Hyung Sik Kim,Hae Young Chung,Mark P. Mattson,Jaewon Lee +8 more
TL;DR: It is suggested that curcumin can stimulate developmental and adult hippocampal neurogenesis, and a biological activity that may enhance neural plasticity and repair is suggested.