Mark P. Mattson

TL;DR: The data suggest that presenilin mutations may promote neuronal degeneration in AD by increasing the sensitivity of neurons to age-related ischemia-like conditions, and drugs that stabilize endoplasmic reticulum calcium homeostasis may prove effective in suppressing the neurodegenerative process in AD patients.

TL;DR: A novel role for TLR3 is revealed in the negative regulation of NPC proliferation in the developing brain in wild type but notTLR3−/−-derived NPCs.

TL;DR: The catalytic subunit of telomerase (TERT) is a specialized reverse transcriptase that has been associated with cell immortalization and cancer as mentioned in this paper, and suppression of TERT levels and function in embryonic mouse hippocampal neurons in culture using antisense technology and the Telomerase inhibitor 3' -azido-2' 3'dideoxythymidine significantly increases their vulnerability to cell death induced by amyloid beta-peptide, a neurotoxic protein believed to promote neuronal degeneration in Alzheimer's disease.

TL;DR: It is concluded that regional neurotransmitter concentrations in a network node strongly predict network but not global brain iFC.

TL;DR: Targeting both peripheral and neuronal deficits, Ex-4 is an attractive agent for therapeutic intervention in Huntington's disease patients suffering from diabetes.