M
Mark P. Mattson
Researcher at Johns Hopkins University School of Medicine
Publications - 988
Citations - 151506
Mark P. Mattson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Glutamate receptor & Neuroprotection. The author has an hindex of 200, co-authored 980 publications receiving 138033 citations. Previous affiliations of Mark P. Mattson include University of Kentucky & National Institutes of Health.
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Exercise and BDNF reduce Aβ production by enhancing α-secretase processing of APP.
Saket M. Nigam,Saket M. Nigam,Shaohua Xu,Joanna S. Kritikou,Krisztina Marosi,Lennart Brodin,Mark P. Mattson +6 more
TL;DR: It is demonstrated that exercise and BDNF reduce production of toxic Aβ peptides through a mechanism involving enhanced α‐secretase processing of APP, and suggests that BDNF's ability to promote neurite outgrowth is primarily exerted through pathways other than APP processing.
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Essential role for integrin linked kinase in Akt-mediated integrin survival signaling in hippocampal neurons.
TL;DR: It is reported that integrin signaling prevents apoptosis of embryonic hippocampal neurons by a mechanism involving integrin‐linked kinase (ILK) that activates Akt kinase.
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Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions
Dong Liu,Deborah L. Croteau,Nadja C. de Souza-Pinto,Nadja C. de Souza-Pinto,Michael Pitta,Jingyan Tian,Christopher Wu,Haiyang Jiang,Khadija Mustafa,Guido Keijzers,Vilhelm A. Bohr,Mark P. Mattson +11 more
TL;DR: OGG1 has a pivotal role in repairing oxidative damage to nuclear DNA under ischemic conditions, thereby reducing brain damage and improving functional outcome.
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Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD.
Annadora J. Bruce-Keller,James W. Geddes,Pamela E. Knapp,Robert W McFall,Jeffrey N. Keller,Frederick W. Holtsberg,Sampath Parthasarathy,Sheldon M. Steiner,Mark P. Mattson +8 more
TL;DR: Results indicate that MnSOD activity directly stabilizes mitochondrial transmembrane potential and calcium buffering ability, thereby increasing the threshold for lethal injury.
Journal ArticleDOI
Effects of amyloid precursor protein derivatives andoxidative stress on basal forebrain cholinergic systems inALZHEIMERS disease
Mark P. Mattson,Ward A. Pedersen +1 more
TL;DR: Knowledge of the cellular and molecular underpinnings of dysfunction and degeneration of cholinergic circuits is leading to the development of novel preventative and therapeutic approaches for Alzheimers disease and related disorders.