M
Mark P. Mattson
Researcher at Johns Hopkins University School of Medicine
Publications - 988
Citations - 151506
Mark P. Mattson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Glutamate receptor & Neuroprotection. The author has an hindex of 200, co-authored 980 publications receiving 138033 citations. Previous affiliations of Mark P. Mattson include University of Kentucky & National Institutes of Health.
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Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke
Joonki Kim,Joonki Kim,Sung Wook Kang,Karthik Mallilankaraman,Sang Ha Baik,James C. Lim,Priyanka Balaganapathy,David T. She,Ker Zhing Lok,David Y. Fann,Uma Thambiayah,Sung-Chun Tang,Alexis M. Stranahan,S. Thameem Dheen,Mathias Gelderblom,Raymond C.S. Seet,Vardan T. Karamyan,Raghu Vemuganti,Christopher G. Sobey,Mark P. Mattson,Mark P. Mattson,Dong-Gyu Jo,Thiruma V. Arumugam,Thiruma V. Arumugam +23 more
TL;DR: The data provide a genetic molecular framework for understanding how IF protects brain cells against damage caused by ischemic stroke, and reveal cellular signaling and bioenergetic pathways to target in the development of clinical interventions.
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Notch1 deficiency decreases hepatic lipid accumulation by induction of fatty acid oxidation.
No-Joon Song,Ui Jeong Yun,Sunghee Yang,Chunyan Wu,Cho-Rong Seo,A-Ryeong Gwon,A-Ryeong Gwon,Sang-Ha Baik,Yuri Choi,Bo Youn Choi,Gahee Bahn,Suji Kim,So-Mi Kwon,Jin Su Park,Seung Hyun Baek,Tae Joo Park,Keejung Yoon,Byung Joon Kim,Mark P. Mattson,Sung Joon Lee,Dong-Gyu Jo,Kye Won Park +21 more
TL;DR: Inhibition of Notch1 signaling can regulate the expression of fatty acid oxidation genes and may provide therapeutic strategies in obesity-induced hepatic steatosis, and similar regulatory effects on lipid accumulation were observed in adipocytes.
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Early involvement of lysosome dysfunction in the degeneration of cerebral cortical neurons caused by the lipid peroxidation product 4-hydroxynonenal.
TL;DR: It is found that neurons exposed to HNE exhibit elevated pH levels, and decreased protein substrate hydrolysis and cathepsin B activity, which may contribute to the accumulation of damaged and dysfunctional proteins and organelles and consequent neuronal death.
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Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis.
Caio Henrique Mazucanti,Elisa Mitiko Kawamoto,Mark P. Mattson,Cristoforo Scavone,Simonetta Camandola +4 more
TL;DR: C cultured hippocampal neurons respond to insulin and glutamate stimulation by elevating Klotho protein levels, and pharmacological inhibition of FGFR1, Erk phosphorylation, and monocarboxylic acid transporters prevents KlothO-induced lactate release from astrocytes.
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The Diversity of Spine Synapses in Animals.
TL;DR: There are two major categories of spine synapses: Invaginating and non-invaginating, with distributions that vary among different groups of animals, and functional advantages of having synapses on spines and more specifically, on invaginating spines.