M
Mark P. Mattson
Researcher at Johns Hopkins University School of Medicine
Publications - 988
Citations - 151506
Mark P. Mattson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Glutamate receptor & Neuroprotection. The author has an hindex of 200, co-authored 980 publications receiving 138033 citations. Previous affiliations of Mark P. Mattson include University of Kentucky & National Institutes of Health.
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Journal ArticleDOI
Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury.
Wenzhen Duan,Jaewon Lee,Jaewon Lee,Zhihong Guo,Mark P. Mattson,Mark P. Mattson,Mark P. Mattson +6 more
TL;DR: These findings provide the first evidence that diet can effect expression of a neurotrophic factor, demonstrate that BDNF signaling plays a central role in the neuroprotective effect of DR, and proffer DR as an approach for reducing neuronal damage in neurodegenerative disorders.
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2-Deoxy-D-glucose protects hippocampal neurons against excitotoxic and oxidative injury: evidence for the involvement of stress proteins.
TL;DR: 2DG treatment increased levels of the stress‐responsive proteins GRP78 and HSP70 in hippocampal neurons, without affecting levels of Bcl‐2 or GRP75, suggesting that mild reductions in glucose availability can increase neuronal resistance to oxidative and metabolic insults by a mechanism involving induction of stress proteins.
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Central Mechanisms of HPA Axis Regulation by Voluntary Exercise
TL;DR: This work reviews the current literature on the hypothalamic-pituitary-adrenal (HPA) axis regulation by wheel running, a voluntary and controllable stressor with a distinct temporal profile and proposes mechanisms to reduce the reactivity to this stressor.
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Notch: from neural development to neurological disorders.
TL;DR: Findings suggest that notch signaling in neurons, glia, and NSCs may be involved in pathological changes that occur in disorders such as stroke, Alzheimer’s disease and CNS tumors.
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Hormesis provides a generalized quantitative estimate of biological plasticity.
TL;DR: The present findings provide the first quantitative estimates of biological plasticity that may be generalized across plant, microbial, animal systems, and across all levels of biological organization.