M
Matthew K. Waldor
Researcher at Harvard University
Publications - 345
Citations - 29581
Matthew K. Waldor is an academic researcher from Harvard University. The author has contributed to research in topics: Vibrio cholerae & Virulence. The author has an hindex of 87, co-authored 322 publications receiving 26506 citations. Previous affiliations of Matthew K. Waldor include East China University of Science and Technology & Tufts University.
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Lysogenic conversion by a filamentous phage encoding cholera toxin.
TL;DR: The emergence of toxigenic V. cholerae involves horizontal gene transfer that may depend on in vivo gene expression, and is shown here to be encoded by a filamentous bacteriophage (designated CTXΦ), which is related to coliphage M13.
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SOS response promotes horizontal dissemination of antibiotic resistance genes
TL;DR: The ‘SOS response’ to DNA damage alleviates this repression, increasing the expression of genes necessary for SXT transfer and hence the frequency of transfer, and presents a mechanism by which therapeutic agents can promote the spread of antibiotic resistance genes.
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Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention
Hans Acha-Orbea,Dennis J. Mitchell,Luika Timmermann,David C. Wraith,Gilbert S. Tausch,Matthew K. Waldor,Scott S. Zamvil,Hugh O. McDevitt,Lawrence Steinman +8 more
TL;DR: Prevention and reversal of autoimmune disease with V beta 8-specific monoclonal antibodies was achieved in EAE because of a striking similarity in fine specificity of T cell receptors.
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Origins of the E. coli Strain Causing an Outbreak of Hemolytic–Uremic Syndrome in Germany
David A. Rasko,Dale R. Webster,Jason W. Sahl,Ali Bashir,Nadia Boisen,Flemming Scheutz,Ellen E. Paxinos,Robert Sebra,Chen-Shan Chin,Dimitris Iliopoulos,Aaron Klammer,Paul Peluso,Lawrence Lee,Andrey Kislyuk,James H. Bullard,Andrew Kasarskis,Susanna Wang,John Eid,David R. Rank,Julia C. Redman,Susan R. Steyert,Jakob Frimodt-Møller,Carsten Struve,Andreas Petersen,Karen A. Krogfelt,James P. Nataro,Eric E. Schadt,Matthew K. Waldor +27 more
TL;DR: The findings suggest that horizontal genetic exchange allowed for the emergence of the highly virulent Shiga-toxin-producing enteroaggregative E. coli O104:H4 strain that caused the German outbreak, and highlight the way in which the plasticity of bacterial genomes facilitates the emerged of new pathogens.
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Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow.
TL;DR: This Review compares and contrasts the core functions for some of the well-studied ICEs and discusses them in the broader context of mobile-element and genome evolution.