M
Michael A. Heneghan
Researcher at University of Cambridge
Publications - 289
Citations - 10869
Michael A. Heneghan is an academic researcher from University of Cambridge. The author has contributed to research in topics: Liver transplantation & Autoimmune hepatitis. The author has an hindex of 51, co-authored 245 publications receiving 9041 citations. Previous affiliations of Michael A. Heneghan include National Health Service & King's College.
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Journal ArticleDOI
Repurposing Diflunisal for Familial Amyloid Polyneuropathy A Randomized Clinical Trial
John L. Berk,Ole B. Suhr,Laura Obici,Yoshiki Sekijima,Steven R. Zeldenrust,Taro Yamashita,Michael A. Heneghan,Peter D. Gorevic,William J. Litchy,Janice F. Wiesman,Erik Nordh,Manuel Corato,Alessandro Lozza,Andrea Cortese,Jessica Robinson-Papp,Theodore Colton,Denis Rybin,Alice Bisbee,Yukio Ando,Shu-ichi Ikeda,David C. Seldin,Giampaolo Merlini,Martha Skinner,Jeffery W. Kelly,Peter J. Dyck +24 more
TL;DR: Among patients with familial amyloid polyneuropathy, the use of diflunisal compared with placebo for 2 years reduced the rate of progression of neurological impairment and preserved quality of life.
Journal ArticleDOI
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis
George F. Mells,James A B Floyd,Katherine I. Morley,Katherine I. Morley,Heather J. Cordell,Christopher S. Franklin,So-Youn Shin,Michael A. Heneghan,James Neuberger,Peter T. Donaldson,Darren B. Day,Samantha J. Ducker,Agnes Muriithi,Elizabeth F Wheater,Christopher J Hammond,Muhammad F. Dawwas,David Jones,Leena Peltonen,Graeme J.M. Alexander,Richard Sandford,Carl A. Anderson +20 more
TL;DR: This study carried out a genome-wide association study (GWAS) using 1,840 cases from the UK PBC Consortium and 5,163 UK population controls as part of theWTCCC3 to identify additional loci, and identified 12 new susceptibility loci and three further new loci in a meta-analysis of data from this study and previously published GWAS results.
Journal ArticleDOI
Optic Nerve Decompression Surgery for Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Is Not Effective and May Be Harmful
Frank Ischemic,Frank J. Hooper,David Kaufman,Nancy J. Newman,P. David Wilson,Z. Suzanne Zam,John S. Kennerdell,Anna Tyutyunikov,Russell Edwards,Todd Goodglick,Deborah Lang,Kimberly Peele,Sophia M. Chung,Diana Mekelburg,John B. Holds,John B. Selhorst,Mark Malton,Sonia Armstrong,Yvonne Mccracken,Eugene Benjamin,Carol Dellinger,Traci Hunter Medlin,Barbara Kinsler,Mike Mcowen,Donna Russell,Timothy Saunders,Gregory S. Kosmorsky,Tina Kiss,Cate Reinhard,Laura Venne,Janet Edgerton,Tami Fecko,Susannah Hanson,Brian Kraus,Deborah Ross,Nancy Tomsak,Pamela Vargo,Rufus Willis,Steven E. Feldon,Kerry Zimmerman,Kristin E. Anderson,Richard Cortez,Karen Deblanc,Judy Hulse,Ronald B. Morales,Tracy Nichols,Lillian Reyes,Nadine Rodarte Ochoa,Daniel Romo,Alfredo A. Sadun,Mary Steber,Frances Walonker,Donna Loupe,Diana Coffman,Harvey Cole,Ted H. Wojno,Barry Skarf,Colleen Wojtala,Mark Croswell,Wendy Gilroy,Christian Mageli,Dena McDonald,George Ponka,Rosa A. Tang,Melissa Hamlin,Jewel Curtis,Jay Forman,Kenneth Hyde,Kirk Mack,Portia Tello,Anthony C. Arnold,Berniee Cibener,Melody Acero,Bobbi Ballenberg,Anne Bolton,Robert J. Goldberg,Lynn K. Gordon,Michael A. Heneghan,Howard R. Krauss,Jackie Sanguinei,Robert Stalling,Jenja Yadegaran,Wayne T. Cornblath,Barbara Michael,Donna Campbell,Cheryl Caudill,Christine Nelson,Jonathan D. Trobe,Lenworth N. Johnson,Gaye Baker,Coy Cobb,Philip Custer,Sharon Turner,Roy D. Wilson,Brian R. Younge,Jacqueline A. Leavitt,Rebecca Nielsen,Jody Allen,Barbara Eickhoff,James A. Garrity,Jacqueline Ladsten,Kathleen Lebarron,Thomas P. Link,Jay A. Rostvold,Karen Weber,Warren L. Felton,Tracy Boney,Danielle Gabriel,Daniel David,Lahn Fendelander,Daniel Geller,Timothy R. Jordan,Christian Kim,Craig Munger,Anne Romandy,George Sanborn,Bradley Schwartz,Carl Sheusi,Constance Smith,Kathy Talley,Sandya Thimmappa,Eric R. Eggenberger,Suzanne Bickert,Robert Granadier,Sandra Holliday,Thomas J. Moore,Jaya Varadarajan,Deborah I. Friedman,Patricia Jones,Haris Amin,Thomas A. Bersani,Cynthia Briglin,James Fooks,Michael Graham,Milton James,Gary Michalec,Hoang Nguyen,Jonathan C. Horton,Maeve Chang,Lou Anne Aber,Erik Lindstrom,Stuart R. Seiff,John Guy,Amye Francis,Latif Hamed,Alan Lessner,Donna Mcdavid,Diana Shamis,James S. Goodwin,Martin E. Lindeman,Allen M. Putterman,Phyllis Bobak,Robert Baker,Judy Beck,David L. Cowen,Avrom Epstein,M.B. Hanson,Toni Scoggins,Ann M. Rodavitch,Brenda Gore,Andrea Blake,Michele Heroux,Rani Kalsi,Charlene Krauch,Mary Ann Millar,Mitchell Wolin,Rita Jean Brady,Regina Hansen,Michael Briggs,Karkarla V. Chalam,Barbara Danner,Beverly Simons,Anne Stewart,Kathleen B. Digre,Lizbeth Malmquist Webb,Terrell Blackburn,Susan Baggaley,Richard C. E. Anderson,Charles Juarez,Bonnie Kaye,Paul D. Langer,Aditya Mishra,Paula Morris,Sandra Osborn,Bhupendra C. Patel,Tessie Priskos,Sandra Staker,Judith E. A. Warner,Christine Evans,Allison Aylor,Carolyn Childress,Helen Dickerson,Jane Fleming,Nomine Harris,L. Sharon Hoyle,Ellen Murphy,James Scott,Karen Summerville,Mariann Terrell,Lillian Tyler,John V. Linberg,Lenore Breen,Michelle Michael,Charlene Campbell,Brian Ellis,Nancy Groves,Robert Hobson,Gordon Mcgregor,Laura Shepherd,Edward S. Cohn,Patricia Manatrey,Sara Casey,John W. Johnson,Coletti Kronner,Virginia Regan,Patricia Streasick,Shalom E. Kelman,Michael J. Elman,Aim M. Rodavitch,Roberta W. Scherer,Barbara Crawley,Cheryl Hiner,Lucy Howard,Patricia Langenberg,Olga Lurye,Sara Riedel,Michelle Sotos,Laureen Spioch,Joann Starr,Judy Urban,Mark Waring,Donald Everett,Kay Dickersin,Robert McCarter,Stuart R. Seiff +234 more
TL;DR: Results from the Ischemic Optic Neuropathy Decompression Trial indicate that optic nerve decompression surgery for NAION is not effective, may be harmful, and should be abandoned.
Journal ArticleDOI
Sex and Age Are Determinants of the Clinical Phenotype of Primary Biliary Cirrhosis and Response to Ursodeoxycholic Acid
Marco Carbone,George F. Mells,Greta Pells,Muhammad F. Dawwas,Julia L. Newton,Michael A. Heneghan,James Neuberger,Darren B. Day,Samantha J. Ducker,Richard Sandford,Graeme J.M. Alexander,David Jones,David Jones +12 more
TL;DR: Among patients with PBC, response to UDCA, treatment and symptoms are related to sex and age at presentation, with the lowest response rates and highest levels of symptoms in women presenting at younger than age 50.
Journal ArticleDOI
Liver disease in pregnancy
TL;DR: An overview of liver diseases that occur in pregnancy, an update on the key mechanisms involved in their pathogenesis, and assessment of available treatment options are provided.