M
Michael D. Buck
Researcher at Francis Crick Institute
Publications - 35
Citations - 7722
Michael D. Buck is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: T cell & Dengue virus. The author has an hindex of 21, co-authored 34 publications receiving 5539 citations. Previous affiliations of Michael D. Buck include La Jolla Institute for Allergy and Immunology & Washington University in St. Louis.
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Journal ArticleDOI
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chih-Hao Chang,Jing Qiu,David O’Sullivan,Michael D. Buck,Takuro Noguchi,Jonathan D. Curtis,Qiongyu Chen,Mariel Gindin,Matthew M. Gubin,Gerritje J.W. van der Windt,Elena Tonc,Robert D. Schreiber,Edward J. Pearce,Erika L. Pearce +13 more
TL;DR: It is shown that tumor-imposed metabolic restrictions can mediate T cell hyporesponsiveness during cancer, and it is found that blocking PD-L1 directly on tumors dampens glycolysis by inhibiting mTOR activity and decreasing expression of gly colysis enzymes.
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Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming
Michael D. Buck,Michael D. Buck,David O’Sullivan,Ramon I. Klein Geltink,Jonathan D. Curtis,Chih-Hao Chang,David E. Sanin,Jing Qiu,Jing Qiu,Oliver Kretz,Oliver Kretz,Daniel Braas,Gerritje J.W. van der Windt,Qiongyu Chen,Stanley Ching-Cheng Huang,Christina M. O’Neill,Brian T. Edelson,Edward J. Pearce,Edward J. Pearce,Hiromi Sesaki,Tobias B. Huber,Tobias B. Huber,Angelika S. Rambold,Angelika S. Rambold,Erika L. Pearce +24 more
TL;DR: The data suggest that, by altering cristae morphology, fusion in TM cells configures electron transport chain (ETC) complex associations favoring oxidative phosphorylation (OXPHOS) and FAO, while fission in TE cells leads to cristsae expansion, reducing ETC efficiency and promoting aerobic glycolysis.
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T cell metabolism drives immunity
TL;DR: The role of lymphocyte metabolism on immune cell development and function and the importance of “goodtenance” in immune cell function is discussed.
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Metabolic Instruction of Immunity
TL;DR: This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease.
Journal ArticleDOI
Memory CD8+ T cells use cell intrinsic lipolysis to support the metabolic programming necessary for development
David O’Sullivan,Gerritje J.W. van der Windt,Stanley Ching-Cheng Huang,Jonathan D. Curtis,Chih-Hao Chang,Michael D. Buck,Jing Qiu,Amber M. Smith,Wing Y. Lam,Lisa M. DiPlato,Fong-Fu Hsu,Morris J. Birnbaum,Edward J. Pearce,Erika L. Pearce +13 more
TL;DR: It is demonstrated that memory T cells rely on cell intrinsic expression of the lysosomal hydrolase LAL (lysosomal acid lipase) to mobilize FA for FAO and memory T cell development, which links LAL to metabolic reprogramming in lymphocytes and shows that cell intrinsic lipolysis is deterministic for memory Tcell fate.