Memory CD8+ T cells use cell intrinsic lipolysis to support the metabolic programming necessary for development
David O’Sullivan,Gerritje J.W. van der Windt,Stanley Ching-Cheng Huang,Jonathan D. Curtis,Chih-Hao Chang,Michael D. Buck,Jing Qiu,Amber M. Smith,Wing Y. Lam,Lisa M. DiPlato,Fong-Fu Hsu,Morris J. Birnbaum,Edward J. Pearce,Erika L. Pearce +13 more
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TLDR
It is demonstrated that memory T cells rely on cell intrinsic expression of the lysosomal hydrolase LAL (lysosomal acid lipase) to mobilize FA for FAO and memory T cell development, which links LAL to metabolic reprogramming in lymphocytes and shows that cell intrinsic lipolysis is deterministic for memory Tcell fate.About:
This article is published in Immunity.The article was published on 2014-07-17 and is currently open access. It has received 601 citations till now.read more
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A guide to immunometabolism for immunologists
TL;DR: A brief refresher course on six of the major metabolic pathways involved in immunometabolism is provided, giving specific examples of how precise changes in the metabolites of these pathways shape the immune cell response.
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Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming
Michael D. Buck,Michael D. Buck,David O’Sullivan,Ramon I. Klein Geltink,Jonathan D. Curtis,Chih-Hao Chang,David E. Sanin,Jing Qiu,Jing Qiu,Oliver Kretz,Oliver Kretz,Daniel Braas,Gerritje J.W. van der Windt,Qiongyu Chen,Stanley Ching-Cheng Huang,Christina M. O’Neill,Brian T. Edelson,Edward J. Pearce,Edward J. Pearce,Hiromi Sesaki,Tobias B. Huber,Tobias B. Huber,Angelika S. Rambold,Angelika S. Rambold,Erika L. Pearce +24 more
TL;DR: The data suggest that, by altering cristae morphology, fusion in TM cells configures electron transport chain (ETC) complex associations favoring oxidative phosphorylation (OXPHOS) and FAO, while fission in TE cells leads to cristsae expansion, reducing ETC efficiency and promoting aerobic glycolysis.
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T cell metabolism drives immunity
TL;DR: The role of lymphocyte metabolism on immune cell development and function and the importance of “goodtenance” in immune cell function is discussed.
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MYC, Metabolism, and Cancer
TL;DR: Because of the reliance of MYC-driven cancers on specific metabolic pathways, synthetic lethal interactions between MYC overexpression and specific enzyme inhibitors provide novel cancer therapeutic opportunities.
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Metabolic Instruction of Immunity
TL;DR: This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease.
References
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Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
Autophagy regulates lipid metabolism
Rajat Singh,Susmita Kaushik,Yongjun Wang,Youqing Xiang,Inna Novak,Masaaki Komatsu,Keiji Tanaka,Ana Maria Cuervo,Mark J. Czaja +8 more
TL;DR: A previously unknown function for autophagy in regulating intracellular lipid stores (macrolipophagy) is identified that could have important implications for human diseases with lipid over-accumulation such as those that comprise the metabolic syndrome.
Journal ArticleDOI
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
Chih-Hao Chang,Jonathan D. Curtis,Leonard B. Maggi,Brandon Faubert,Alejandro V. Villarino,David O’Sullivan,Stanley Ching-Cheng Huang,Gerritje J.W. van der Windt,Julianna Blagih,Jing Qiu,Jason D. Weber,Edward J. Pearce,Russell G. Jones,Erika L. Pearce +13 more
TL;DR: It is shown here that aerobic glycolysis is specifically required for effector function in T cells but that this pathway is not necessary for proliferation or survival.
Journal ArticleDOI
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Ruoning Wang,Christopher P. Dillon,Lewis Zhichang Shi,Sandra Milasta,Robert Carter,David Finkelstein,Laura L. McCormick,Patrick Fitzgerald,Hongbo Chi,Joshua Munger,Douglas R. Green +10 more
TL;DR: Metabolic tracer analysis revealed a Myc-dependent metabolic pathway linking glutaminolysis to the biosynthesis of polyamines, which may represent a general mechanism for metabolic reprogramming under patho-physiological conditions.
Journal ArticleDOI
Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
Ryan D. Michalek,Valerie A. Gerriets,Sarah R. Jacobs,Andrew N. Macintyre,Nancie J. MacIver,Emily F. Mason,Sarah A. Sullivan,Amanda G. Nichols,Jeffrey C. Rathmell +8 more
TL;DR: Teff and Treg were selectively increased in Glut1 transgenic mice and reliant on glucose metabolism, whereas Treg had activated AMP-activated protein kinase and were dependent on lipid oxidation.