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Michael Hughes

Researcher at Royal Hallamshire Hospital

Publications -  615
Citations -  26328

Michael Hughes is an academic researcher from Royal Hallamshire Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 74, co-authored 531 publications receiving 24066 citations. Previous affiliations of Michael Hughes include Royal College of Physicians & St Thomas' Hospital.

Papers
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Antiretroviral therapy during pregnancy and the risk of an adverse outcome

Ruth Tuomala, +10 more
- 01 Nov 2002 - 
TL;DR: Findings provide reassurance that there is a low risk of adverse pregnancy outcomes from antiretroviral treatment, and whatever increased risk exists is likely to be counterbalanced by the acknowledged benefits of antireteviral treatment during pregnancy.
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An Overview of Different Techniques for Improving the Treatment of Pulmonary Hypertension Secondary in Systemic Sclerosis Patients

Barbara Ruaro, +10 more
- 01 Mar 2022 - 
TL;DR: The main tool to screen PAH is transthoracic echocardiography (TTE), which has a sensitivity of 90%, even if definitive diagnosis should be confirmed by right heart catheterization (RHC).
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The Design of Single-Arm Clinical Trials of Combination Antiretroviral Regimens for Treatment-Naive HIV-Infected Patients

Lu Zheng, +5 more
- 05 Apr 2013 - 
TL;DR: Key design considerations for single-arm clinical trials to establish initial estimates of efficacy and safety/tolerability of novel regimens to inform the design of large phase III trials are discussed.
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Drug Development Strategies for Salvage Therapy: Conflicts and Solutions

Victor De Gruttola, +5 more
- 05 Dec 2006 - 
TL;DR: This work focuses much of its discussion on salvage studies of antiviral drugs, as pharmaceutical companies drive much of the current research agenda and can largely specify how they would like their agents to be tested.
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Anabolic androgenic steroid induced necrotising myopathy

Michael Hughes, +1 more
- 01 Jul 2011 - 
TL;DR: A 23-year-old gentleman who developed a severe generalised necrotising myopathy required intensive care support from the development of multi-organ failure after investigations failed to demonstrate an infective, inflammatory, metabolic or inherited aetiology.