M
Michael Hughes
Researcher at Royal Hallamshire Hospital
Publications - 615
Citations - 26328
Michael Hughes is an academic researcher from Royal Hallamshire Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 74, co-authored 531 publications receiving 24066 citations. Previous affiliations of Michael Hughes include Royal College of Physicians & St Thomas' Hospital.
Papers
More filters
Journal ArticleDOI
Lymphoma Diagnosis and Plasma Epstein-Barr Virus Load during Vicriviroc Therapy: Results of the AIDS Clinical Trials Group A5211
Athe M. N. Tsibris,Roger Paredes,Amy Chadburn,Zhaohui Su,Timothy J. Henrich,Amy Krambrink,Michael Hughes,Judith A. Aberg,Judith S. Currier,Karen T. Tashima,Catherine Godfrey,Wayne Greaves,Charles Flexner,Paul R. Skolnik,Timothy J. Wilkin,Roy M. Gulick,Daniel R. Kuritzkes,Daniel R. Kuritzkes +17 more
TL;DR: CCR5 antagonism by vicriviroc treatment in treatment-experienced patients was not associated with reactivation of EBV infection and plasma EBV DNA levels were not increased.
Journal Article
Simulation studies of surrogate endpoint validation using single trial and multitrial statistical approaches.
Marissa Lassere,Kent J. Johnson,Michael Hughes,Doug G Altman,Marc Buyse,Sally Galbraith,George Wells +6 more
TL;DR: This report surveys the literature on methods of statistical validation of surrogate markers and compares these methods head-to-head using simulated datasets and shows that summary statistics developed specifically to establish surrogate validity were problematic.
Journal ArticleDOI
Renal events among women treated with tenofovir/emtricitabine in combination with either lopinavir/ritonavir or nevirapine
Albert Mwafongo,Kondwani Nkanaunena,Yu Zheng,Evelyn Hogg,Wadzanai Samaneka,Lloyd Mulenga,Abraham Siika,Judith S. Currier,Shahin Lockman,Michael Hughes,Mina C. Hosseinipour +10 more
TL;DR: Patients taking TDF co-administered with LPV/r had significantly more renal events compared to those co- Administered with NVP, and higher baseline HIV RNA and lower creatinine clearance were associated with the development of renal insufficiency requiring treatment modification.
Proceedings ArticleDOI
Implant bone interface investigated with a non-invasive method: optical coherence tomography
Cosmin Sinescu,Michael Hughes,Adrian Bradu,Meda Lavinia Negrutiu,Carmen Todea,Sergiu Antonie,Philippe L. Laissue,Mihai Rominu,Adrian Gh. Podoleanu +8 more
TL;DR: It is demonstrated that en-face optical coherence tomography can be used to evaluate implant bone interface analysis and shows gaps of different sizes and shapes between the implant and the bone at different depths.
Journal ArticleDOI
Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial
Cassie M Mitchell,Cassie M Mitchell,Brenda M. Davy,Monica A. Ponder,Ryan P. McMillan,Michael Hughes,Matthew W. Hulver,Andrew P. Neilson,Kevin P. Davy +8 more
TL;DR: Inulin supplementation has been shown to improve glucose metabolism and reduce T2D risk in adults with Type 2 diabetes as mentioned in this paper, however, it did not improve peripheral insulin sensitivity and Bifidobacteria 16s.