M
Michael Hughes
Researcher at Royal Hallamshire Hospital
Publications - 615
Citations - 26328
Michael Hughes is an academic researcher from Royal Hallamshire Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 74, co-authored 531 publications receiving 24066 citations. Previous affiliations of Michael Hughes include Royal College of Physicians & St Thomas' Hospital.
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Journal ArticleDOI
Dynamics of the resting CD4(+) T-cell latent HIV reservoir in infants initiating HAART less than 6 months of age.
Deborah Persaud,Paul Palumbo,Carrie Ziemniak,Michael Hughes,Carmelita Alvero,Katherine Luzuriaga,Ram Yogev,Edmund V. Capparelli,Ellen G. Chadwick +8 more
TL;DR: Although the resting CD4+ T-cell latent HIV reservoir remains detectable over the first 2 years of HAART in a substantial proportion of infants, its size is associated with time to first undetectable viral load.
Journal ArticleDOI
Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study
John H. Beigel,Pablo Tebas,Marie-Carmelle Elie-Turenne,Ednan K. Bajwa,Todd Bell,Charles B. Cairns,Shmuel Shoham,Jaime G. Deville,Eric Feucht,Judith Feinberg,Thomas C. Luke,Kanakatte Raviprakash,Janine Danko,Dorothy O'Neil,Julia A. Metcalf,Karen King,Timothy H Burgess,Evgenia Aga,H. Clifford Lane,Michael Hughes,Richard T. Davey,Joseph B. Quinn,Yan Jiang,Robyn Hoelle,Nicole M. Iovine,Robert Shawn Wills,Socorro Pata,Monique Huggins,Belinda Manukian,Carrie A. Holland,Kelsey Brait,Taylor Hunt,Christopher Stowell,Amy Slater,Mary Townsends,Eugenia B Quackenbush,Yara A Park,Paul Gaither Jordan,Cherie Blanchet,Kevin Chronowski,Kathleen Alvarez,Darin Ostrander,Terry Woessner,Sandra Thoman,James Lin,Alyssa Ziman,Kavita Shankar,Tom Blok,Don Batts,Bob Beck,Gail Massey,Carol Bradley,Patricia M. Carey,Jenifer Baer,Eva Moore Whitehead,Sharon Kohrs,Robert Giulitto,Christina Schofield,Mary Fairchok,Susan Chambers,Cindy Baker,Michelle Parker,Marta Harshbarger,M Hong Nguyen,Mary Ellen Carey,Julie Paronish,Frank Cornell,Jim Cramer,Diana Lynn Pakstis,Michael G. Ison,Richard G. Wunderink,Marshall J. Glesby,Kirsis Ham,Valery G Hughes,Melissa M. Cushing,Cheryl Goss,Joanne Grenade,Pauline K. Park,Lena M. Napolitano,Krishnan Raghavendran,Robert C. Hyzy,Robertson D. Davenport,Kristin Brierley,Theresa Downs,Michelle N. Gong,Joan Uehlinger,Michael Y. Lin,Janice M. Fritsche,Tondria Green,Bruce McLeod,Deena Patel,Mary F Bavaro,Robert Deiss,Carolyn Brandt,Stephanie Cammarata,Allan Kremp,Karine Hollis-Perry,Tahaniyat Lalani,Susan Banks,Jacqueline Johnson,Jason Maguire,Janet McNiff,Leslie E Rigg,Anuradha Ganesan,Irma Barahona,Steven Spencer,David Stagliano,Timothy Burgess,Daniel Talmor,Monique Mohammed,Valerie Banner-Goodspeed,Robert A. Salata,Robert W. Finberg,Jennifer P. Wang,Karen Longtine,Jaclyn Longtine,Mellissa O'Neil,Philippe R. Bauer,Ognjen Gajic,Suanne M Weist,Jonathan E. Sevransky,Mona Brown,John D. Roback,John Oropello,Bridget Twohig,Jeffrey Jhang,Rahgu Seethala,Wilbur H Chen,Magali J. Fontaine,Kapil Saharia,Jennifer Husson,Roberta DeBiasi,Jurran L Wilson,Valli Ree Criss,Jocelyn Voell,Susan Leitman,James Wade Atkins,Hemaxi Patel,Traci Paige,Cathy Cantilena,Donald Siegel,Faye DeMuth,Craig H Fletcher,J Peter R Pelletier,Hassan Alnuaimat,Michelle Pourde +145 more
TL;DR: The safety and efficacy of anti-influenza plasma with haemagglutination inhibition antibody titres of 1:80 or more to the infecting strain seemed safe and well tolerated in this randomised, open-label, multicentre, phase 2 trial.
Journal ArticleDOI
Genetic Influence of CCR5, CCR2 and SDF1 Variants on Human Immunodeficiency Virus 1 (HIV-1)–Related Disease Progression and Neurological Impairment, in Children with Symptomatic HIV-1 Infection
Kumud K. Singh,Charlene F. Barroga,Michael Hughes,Jie Chen,Claire Raskino,Ross E. McKinney,Stephen A. Spector +6 more
TL;DR: In children with the C CR5-wt/wt genotype, variants at CCR5-59029 have the broadest impact on disease progression, suggesting that, in children, host genetics plays an important role in HIV-1-related disease progression and neurological impairment.
Journal ArticleDOI
Pharmacokinetics and Safety of Indinavir in Human Immunodeficiency Virus-Infected Pregnant Women
Jashvant D. Unadkat,Diane W. Wara,Michael Hughes,Anita Mathias,Diane T. Holland,Mary E. Paul,James D. Connor,Sharon Huang,Bach Yen Nguyen,D. Heather Watts,Lynne M. Mofenson,Elizabeth Smith,Deutsch Paul J,Kathleen A. Kaiser,Ruth Tuomala +14 more
TL;DR: Indinavir area under the plasma concentration-time curve was 68% lower antepartum versus postpartum, suggesting increased intestinal and/or hepatic CYP3A activity during pregnancy.
Journal ArticleDOI
The Moral Basis of Moral Reform: Status Discontent vs. Culture and Socialization as Explanations of Anti-Pornography Social Movement Adherence
Michael Wood,Michael Hughes +1 more
TL;DR: The authors evaluated two explanations of the social base of moral reform movements and found that various structural conditions, such as being geographically mobile from rural areas, being self-employed, or being status discrepant, have no effect on anti-pornography social movement adherence when variables representing different socialization experiences and cultural environments are taken into account.